13 research outputs found
Technologie des joints dynamiques des machines tournantes
SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : 26165 A, issue : a.1997 n119 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Tentative D’Une Feuille De Route Sur La Gestion Efficiente De La Diversité AU Sein Des Entreprises Camerounaises (An Attempt of a Roadmap for an Efficient Management of Diversity Within Cameroonian Enterprises)
Selectivity and proofreading both contribute significantly to the fidelity of RNA polymerase III transcription
Papular-purpuric "gloves and socks" syndrome due to parvovirus B19: report of a case with unusual features
The TFIIF-Like Rpc37/53 Dimer Lies at the Center of a Protein Network To Connect TFIIIC, Bdp1, and the RNA Polymerase III Active Center
Molecular structures of unbound and transcribing RNA polymerase III
Transcription of genes encoding small structured RNAs such as tRNAs, spliceosomal U6 snRNA and ribosomal 5S RNA is carried out by RNA polymerase III (Pol III), the largest yet structurally least characterized eukaryotic RNA polymerase. The cryo-EM structures of the S. cerevisiae Pol III elongating complex at 3.9 Å resolution and the apo Pol III enzyme in two different conformations at 4.6 and 4.7 Å resolution, respectively, allow for the first time to build a 17-subunit atomic model of Pol III. The reconstructions reveal the precise orientation of the C82/C34/C31 heterotrimer in close proximity to the stalk. The C53/C37 heterodimer positions residues involved in transcription termination close to the non-template DNA strand. In the apo Pol III structures, the stalk adopts different orientations coupled with closed and open conformations of the clamp. Our results provide novel insights into Pol III-specific transcription and the adaptation of Pol III towards its small transcriptional targets