1,328 research outputs found
NewOX - extending the online exXam system to provide automated formative evaluation of student text-based assignments
A cheat-resistant and foolproof distributed electronic application for summativeassessment of student learning outcomes has been developed and field tested "OnlineeXam" (OX). Good usability experience and feedback features for the students as wellas the lecturers were design goals of the implementation. The field tests showed therobustness of the system in a heterogenic PC pool environment, the ease of use and agood student learning outcome assessment ability (summative assessment) but a lackof a formative impact on the student learning efforts. The incorporation and adoption(for European needs) of a short essay assessment algorithm with a rich user interfaceis proposed
XMM-Newton and INTEGRAL observations of the black hole candidate XTE J1817-330
The galactic black hole candidate XTE J1817-330 was discovered in outburst by
RXTE in January 2006. We present here the results of an XMM-Newton Target of
opportunity observation (TOO), performed on 13 March 2006 (44 days after the
maximum), and an INTEGRAL observation performed on 15-18 February 2006 (18 days
after the maximum). The EPIC-pn camera on-board XMM-Newton was used in the fast
read-out Burst mode to avoid photon pile-up, while the RGSs were used in
Spectroscopy high count-rate mode. We fit both the XMM-Newton and the INTEGRAL
spectra with a two-component model consisting of a thermal accretion disk and a
comptonizing hot corona. The soft X-ray spectrum is dominated by an accretion
disk component, with a maximum temperature decreasing from 0.96+/-0.04 keV at
the time of the INTEGRAL observation to 0.70+/-m0.01 keV on 13 March. The
Optical Monitors on board INTEGRAL and XMM-Newton showed the source with
magnitudes V: 11.3-11.4, U:15.0-15.1 and UVW1:14.7-14.8. The soft X-ray
spectrum, together with the optical and UV data, show a low hydrogen column
density towards the source, and several absorption lines, most likely of
interstellar origin, are detected in the RGS spectrum: OI K-alpha, OI K-beta,
OII, OIII and OVII, which trace both cold and hot components of the ISM. The
soft X-ray spectrum indicates the presence of a black hole, with an estimate
for the upper limit of the mass of 6.0(+4.0/-2.5) Msun.Comment: Accepted for publication in A&
Ground-based intercomparison of two isoprene measurement techniques
International audienceAn informal intercomparison of two isoprene (C5H8) measurement techniques was carried out during Fall of 1998 at a field site located approximately 3 km west of Boulder, Colorado, USA. A new chemical ionization mass spectrometric technique (CIMS) was compared to a well-established gas chromatographic technique (GC). The CIMS technique utilized benzene cation chemistry to ionize isoprene. The isoprene levels measured by the CIMS were often larger than those obtained with the GC. The results indicate that the CIMS technique suffered from an anthropogenic interference associated with air masses from the Denver, CO metropolitan area as well as an additional interference occurring in clean conditions. However, the CIMS technique is also demonstrated to be sensitive and fast. Especially after introduction of a tandem mass spectrometric technique, it is therefore a candidate for isoprene measurements in remote environments near isoprene sources
Analyzing X-Ray Pulsar Profiles: Geometry and Beam Pattern of Her X-1
We report on our analysis of a large sample of energy dependent pulse
profiles of the X-ray binary pulsar Hercules X-1. We find that all data are
compatible with the assumption of a slightly distorted magnetic dipole field as
sole cause of the asymmetry of the observed pulse profiles. Further the
analysis provides evidence that the emission from both poles is equal. We
determine an angle of 20 deg between the rotation axis and the local magnetic
axis. One pole has an offset of 5 deg from the antipodal position of the other
pole. The beam pattern shows structures that can be interpreted as pencil- and
fan-beam configurations. Since no assumptions on the polar emission are made,
the results can be compared with various emission models. A comparison of
results obtained from pulse profiles of different phases of the 35-day cycle
indicates different attenuation of the radiation from the poles being
responsible for the change of the pulse shape during the main-on state. These
results also suggest the resolution of an ambiguity within a previous analysis
of pulse profiles of Cen X-3, leading to a unique result for the beam pattern
of this pulsar as well. The analysis of pulse profiles of the short-on state
indicates that a large fraction of the radiation cannot be attributed to the
direct emission from the poles. We give a consistent explanation of both the
evolution of the pulse profile and the spectral changes with the 35-day cycle
in terms of a warped precessing accretion disk.Comment: 24 pages, 12 figures. To appear in ApJ 529 #2, 1 Feb 200
Probing the outer edge of an accretion disk : a Her X-1 turn-on observed with RXTE
We present the analysis of Rossi X-ray Timing Explorer (RXTE) observations of the turn-on phase of a 35 day cycle of the X-ray binary Her X-1. During the early phases of the turn-on, the energy spectrum is composed of X-rays scattered into the line of sight plus heavily absorbed X-rays. The energy spectra in the 3–17 keV range can be described by a partial covering model, where one of the components is influenced by photoelectric absorption and Thomson scattering in cold material plus an iron emission line at 6.5 keV. In this paper we show the evolution of spectral parameters as well as the evolution of the pulse profile during the turn-on. We describe this evolution using Monte Carlo simulations which self-consistently describe the evolution of the X-ray pulse profile and of the energy spectrum
Highly efficient 5\u27 capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD+ and NADH, and do so more efficiently than nuclear RNAPs. Direct quantitation of NAD+- and NADH-capped RNA demonstrates remarkably high levels of capping in vivo: up to ~60% NAD+ and NADH capping of yeast mitochondrial transcripts, and up to ~15% NAD+ capping of human mitochondrial transcripts. The capping efficiency is determined by promoter sequence at, and upstream of, the transcription start site and, in yeast and human cells, by intracellular NAD+ and NADH levels. Our findings indicate mtRNAPs serve as both sensors and actuators in coupling cellular metabolism to mitochondrial transcriptional outputs, sensing NAD+ and NADH levels and adjusting transcriptional outputs accordingly. © 2018, Bird et al
Geant4-related R&D for new particle transport methods
A R&D project has been launched in 2009 to address fundamental methods in
radiation transport simulation and revisit Geant4 kernel design to cope with
new experimental requirements. The project focuses on simulation at different
scales in the same experimental environment: this set of problems requires new
methods across the current boundaries of condensed-random-walk and discrete
transport schemes. An exploration is also foreseen about exploiting and
extending already existing Geant4 features to apply Monte Carlo and
deterministic transport methods in the same simulation environment. An overview
of this new R&D associated with Geant4 is presented, together with the first
developments in progress.Comment: 4 pages, to appear in proceedings of the Nuclear Science Symposium
and Medical Imaging Conference 2009, Orland
Spirometry reference equations for central European populations from school age to old age.
Spirometry reference values are important for the interpretation of spirometry results. Reference values should be updated regularly, derived from a population as similar to the population for which they are to be used and span across all ages. Such spirometry reference equations are currently lacking for central European populations. To develop spirometry reference equations for central European populations between 8 and 90 years of age. We used data collected between January 1993 and December 2010 from a central European population. The data was modelled using "Generalized Additive Models for Location, Scale and Shape" (GAMLSS). The spirometry reference equations were derived from 118'891 individuals consisting of 60'624 (51%) females and 58'267 (49%) males. Altogether, there were 18'211 (15.3%) children under the age of 18 years. We developed spirometry reference equations for a central European population between 8 and 90 years of age that can be implemented in a wide range of clinical settings
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