Observations of OJ 287 from the Geodetic VLBI Archive of the Washington Correlator

We present 27 geodetic VLBI maps of OJ 287 obtained from the archive of the Washington correlator. The observations presented here were made between 1990 October and 1996 December. During this period a sequence of six superluminal components has been identified. We measured the proper motion of these components to be approximately 0.5 mas/yr, which is about twice as high as that seen in previous VLBI observations. These results imply a higher component ejection rate than previously observed, in good agreement with the observed occurrences of radio outbursts. We have examined a possible connection between VLBI components and optical flares in the framework of a binary black hole system.Comment: 9 pages, 5 included figures, emulateapj.sty, accepted to The Astrophysical Journa

Variation in health and social equity in the spaces where we live: A review of previous literature from the GeoHealth Laboratory

The previous decade has given rise to the importance of Geographic Information Systems (GIS) in explaining inequalities in health outcomes between groups based on their spatial location and social background. The GeoHealth Laboratory, based at the University of Canterbury, is a joint venture with the Health and Disability Intelligence unit within the Ministry of Health (MoH). The aims of this relationship are to add analytical capacity to MoH data collections and increase academic outputs of geospatial health research in New Zealand. GeoHealth research has often been a joint venture between Laboratory staff and students as well as collaboration with local and international researchers. These partnerships along with widely varied research interests have resulted in a large contribution of spatial health research in the field of health geography. This article reports on research undertaken by the GeoHealth Laboratory that has focused on access to neighbourhood determinants of health. An overview of key neighbourhoods and health research areas are outlined within the over-arching themes of indices of access to neighbourhood factors, access to undesireable neighbourhood destinations, health promoting neighbourhood factors, access to and utilisation of health services, and complementary data collection and research groups within New Zealand

National movement patterns during the COVID-19 pandemic in New Zealand:The unexplored role of neighbourhood deprivation

BACKGROUND: The COVID-19 pandemic has asked unprecedented questions of governments around the world. Policy responses have disrupted usual patterns of movement in society, locally and globally, with resultant impacts on national economies and human well-being. These interventions have primarily centred on enforcing lockdowns and introducing social distancing recommendations, leading to questions of trust and competency around the role of institutions and the administrative apparatus of state. This study demonstrates the unequal societal impacts in population movement during a national ‘lockdown’. METHODS: We use nationwide mobile phone movement data to quantify the effect of an enforced lockdown on population mobility by neighbourhood deprivation using an ecological study design. We then derive a mobility index using anonymised aggregated population counts for each neighbourhood (2253 Census Statistical Areas; mean population n=2086) of national hourly mobile phone location data (7.45 million records, 1 March 2020–20 July 2020) for New Zealand (NZ). RESULTS: Curtailing movement has highlighted and exacerbated underlying social and spatial inequalities. Our analysis reveals the unequal movements during ‘lockdown’ by neighbourhood socioeconomic status in NZ. CONCLUSION: In understanding inequalities in neighbourhood movements, we are contributing critical new evidence to the policy debate about the impact(s) and efficacy of national, regional or local lockdowns which have sparked such controversy

Observations of BL Lacertae from the Geodetic VLBI Archive of the Washington Correlator

We present maps of BL Lac obtained from geodetic VLBI data from the archive of the Washington correlator. The observations were made from 1996 March to 1996 November, with periods from one experiment to another as short as 1 month. The dominant structure of the maps is given by a superluminal component (C2) moving predominantly at position angle ~190°. At the later epochs a new superluminal component (C3) emerges from the core and moves along a trajectory at a higher position angle (200°). We also include maps from observations made in 1995 June and August showing the main component (C2) in the early stages of its evolution, as well as an older component (C1). The position angle of the component C1 is nearly the same as that of the new component C3. The component C2 shows indications of nonradial motion, which is discussed in terms of a helically distorted jet. The best fit was obtained for a half-opening angle of the jet of 2.6d and an angle of the helical axis to the line of sight of 17°

Observations of OJ 287 from the Geodetic-VLBI Archive of the Washington Correlator

We present 27 geodetic VLBI maps of OJ 287 obtained from the archive of the Washington correlator. The observations presented here were made between 1990 October and 1996 December. During this period a sequence of six superluminal components has been identified. We measured the proper motion of these components to be approximately 0.5 mas yr-1, which is about twice as high as that seen in previous VLBI observations. These results imply a higher component ejection rate than previously observed, in good agreement with the observed occurrences of radio outbursts. We have examined a possible connection between VLBI components and optical flares in the framework of a binary black hole system

Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells.

Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected by the loss of the ubiquitously expressed SMN protein. Using a mouse embryonic stem cell (mESC) model for severe SMA, the RNA transcript profiles (transcriptomes) between control and severe SMA (SMN2+/+;mSmn-/-) mESC-derived MNs were compared in this study using massively parallel RNA sequencing (RNA-Seq). The MN differentiation efficiencies between control and severe SMA mESCs were similar. RNA-Seq analysis identified 3,094 upregulated and 6,964 downregulated transcripts in SMA mESC-derived MNs when compared against control cells. Pathway and network analysis of the differentially expressed RNA transcripts showed that pluripotency and cell proliferation transcripts were significantly increased in SMA MNs while transcripts related to neuronal development and activity were reduced. The differential expression of selected transcripts such as Crabp1, Crabp2 and Nkx2.2 was validated in a second mESC model for SMA as well as in the spinal cords of low copy SMN2 severe SMA mice. Furthermore, the levels of these selected transcripts were restored in high copy SMN2 rescue mouse spinal cords when compared against low copy SMN2 severe SMA mice. These findings suggest that SMN deficiency affects processes critical for normal development and maintenance of MNs

VSOP and Ground-based VLBI Imaging of the TeV Blazar Markarian 421 at Multiple Epochs

We present thirty VLBI images of the TeV blazar Markarian 421 (1101+384) at fifteen epochs spanning the time range from 1994 to 1997, and at six different frequencies from 2.3 to 43 GHz. The imaged observations include a high-resolution 5 GHz VLBI Space Observatory Programme (VSOP) observation with the HALCA satellite on 1997 November 14; full-track VLBA observations from 1994 April, 1996 November, and 1997 May at frequencies between 5 and 43 GHz; six epochs of VLBA snapshot observations at frequencies between 2 and 15 GHz from Radio Reference Frame studies; and five geodetic VLBI observations at 2 and 8 GHz from the archive of the Washington VLBI Correlator Facility located at the U.S. Naval Observatory. The dense time coverage of the images allows us to unambiguously track components in the parsec-scale jet over the observed time range. We measure the speeds of three inner jet components located between 0.5 and 5 mas from the core (0.3 to 3 pc projected linear distance) to be 0.19 +/- 0.27, 0.30 +/- 0.07, and -0.07 +/- 0.07 c (H_{0}=65 km s^{-1} Mpc^{-1}). If the sole 43 GHz image is excluded, all measured speeds are consistent with no motion. These speeds differ from tentative superluminal speeds measured by Zhang & B\aa\aa th from three epochs of data from the early 1980's. Possible interpretations of these subluminal speeds in terms of the high Doppler factor demanded by the TeV variability of this source are discussed.Comment: 18 pages, including 7 figures, emulateapj.sty, accepted by The Astrophysical Journal; modified text describing Radio Reference Frame observation

The effect of price increases on predicted alcohol purchasing decisions and choice to substitute

Introduction: Few studies have undertaken to explore whether people who consume particular alcoholic beverages have a greater tendency to substitute with cheaper alcohol in response to price increases. The aim of this study was to investigate the effect of price increases on alcohol purchasing decisions, specifically the influence on brand and cross-beverage substitution across demographic, drinking level and socio-economic factors. Method: Data on participants’ alcohol purchasing habits and consumption were collected via an online survey, including their reactions to three price increases to alcoholic beverages types previously purchased. Data were analysed using logistic regression, with substitution behaviour the dependent variable, controlling for demographic and socio-economic factors. Results: Responses to different price increases varied by drinking level, which was consistently and significantly associated with likelihood of substitution behaviour across beverage types. For a 50% increase in price, regardless of whether participants purchased beer, wine, bottled spirits or premixed spirits, drinking at levels which put participants at high risk of short-term harms was associated with a higher likelihood of substitution with cheaper brands or beverage types (OR: 1.729; OR: 1.787; OR: 1.729 and OR: 1.729, respectively). Conclusions: No consistent trends in responses occurred according to respondent characteristics, suggesting that increasing price may be an effective tool to influence purchasing behaviour across the population. Results also suggested that those who drink at levels which put them at high risk of short-term harms may be more likely to circumvent price increases by switching to a cheaper product

Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136316/1/cncr30351_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136316/2/cncr30351.pd

A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male

We report a rare synchronous presentation of adrenocortical carcinoma (ACC) and papillary thyroid carcinoma (PTC). A 31-year-old male first presented with a large left adrenal mass that was identified during the workup for refractory hypertension due to hyperaldosteronism. The mass was removed surgically with pathology showing ACC. The patient was then treated with adjuvant radiation therapy and mitotane chemotherapy. Four months post ACC resection, metastatic ACC to the right upper lung and PTC in the left lobe of the thyroid were found in surveillance imaging. He subsequently developed pulmonary, contralateral adrenal and brain metastases from his ACC. Li Fraumeni syndrome and Multiple Endocrine Neoplasia Type I (MEN I) were considered, but testing of both P53 and menin genes showed no mutation. We also performed a review of the literature and found three similar cases, however gene mutation analysis was not performed.