The Population Need in Genetic Tests for Predisposition to Breast Cancer

The article presents the results of sociological survey of women of the Republic of Tatarstan (Russia) concerning establishment of level of awareness about risks of development of oncologic diseases, need for application of genetic tests determining predisposition to breast and ovary cancer and also motives of acceptance or nonacceptance of existing modes of diagnostic and prevention of oncologic diseases. The breast and ovary cancer are among the most prevalent causes of female mortality in Russia. It is established that females with gene mutations BRCA1 and BRCA2 have a higher risk of development of breast and ovary cancer. Therefore, to determine character of genes BRCA in human genome is actual for prevention of oncologic diseases. The early diagnostic of oncologic diseases can significantly increase effectiveness of struggle with similar illnesses. The obtained data shows superficial awareness of Russian females about problem of breast and ovary cancer. The majority knows about existence of gene predisposition to disease but are not aware of characteristics of diagnostic, prevention and treatment of of these types of oncologic diseases. The female respondents in most cases are favorable to pass genetic diagnostic. However, they demonstrate nonacceptance of such radical mode of problem solution as preventive surgery of ablation of potentially dangerous organ. The most of female respondents prefer strategies of traditional monitoring for early detection of disease. The main causes of refusal of early gene diagnostic and preventive surgery are related, besides psychological and personal phobias, to such factors as distrust to health care system and uncertainty in qualification and accessibility of medical care

Analysis of drift effects on the tokamak power scrape-off width using SOLPS-ITER

SOLPS-ITER, a comprehensive 2D scrape-off layer modeling package, is used to examine the physical mechanisms that set the scrape-off width (lambda(q)) for inter-ELM power exhaust. Guided by Goldston\u27s heuristic drift (HD) model, which shows remarkable quantitative agreement with experimental data, this research examines drift effects on lambda(q) in a DIII-D H-mode magnetic equilibrium. As a numerical expedient, a low target recycling coefficient of 0.9 is used in the simulations, resulting in outer target plasma that is sheath limited instead of conduction limited as in the experiment. Scrape-off layer (SOL) particle diffusivity (D-SOL) is scanned from 1 to 0.1 m(2) s(-1). Across this diffusivity range, outer divertor heat flux is dominated by a narrow (similar to 3-4 mm when mapped to the outer midplane) electron convection channel associated with thermoelectric current through the SOL from outer to inner divertor. An order-unity up-down ion pressure asymmetry allows net ion drift flux across the separatrix, facilitated by an artificial mechanism that mimics the anomalous electron transport required for overall ambipolarity in the HD model. At D-SOL = 0.1 m(2) s(-1), the density fall-off length is similar to the electron temperature fall-off length, as predicted by the HD model and as seen experimentally. This research represents a step toward a deeper understanding of the power scrape-off width, and serves as a basis for extending fluid modeling to more experimentally relevant, high-collisionality regimes

Drifts, currents, and power scrape-off width in SOLPS-ITER modeling of DIII-D

The effects of drifts and associated flows and currents on the width of the parallel heat flux channel (lambda(q)) in the tokamak scrape-offlayer (SOL) are analyzed using the SOLPS-ITER 2D fluid transport code. Motivation is supplied by Goldston\u27s heuristic drift (HD) model for lambda(q), which yields the same approximately inverse poloidal magnetic field dependence seen in multi-machine regression. The analysis, focusing on a DIII-D H-mode discharge, reveals HD-like features, including comparable density and temperature fall-off lengths in the SOL, and up-down ion pressure asymmetry that allows net cross-separatrix ion magnetic drift flux to exceed net anomalous ion flux. In experimentally relevant high-recycling cases, scans of both toroidal and poloidal magnetic field (B-tor and B-pol) are conducted, showing minimal lambda(q) dependence on either component of the field. Insensitivity to B-tor is expected, and suggests that SOLPS-ITER is effectively capturing some aspects of HD physics. Absence of lambda(q) dependence on B-pol, however, is inconsistent with both the HD model and experimental results. The inconsistency is attributed to strong variation in the parallel Mach number, which violates one of the premises of the HD model. (C) 2016 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Role of turbulence and electric fields in the formation of transport barriers and the establishment of improved confinement in tokamak plasmas through inter-machine comparison

Over the past decade new regimes of tokamak operation have been identified, whereby electrostatic and magnetic turbulence responsible for anomalous transport, can be externally suppressed, leading to improved confinement. Although turbulence measurements have been performed on many confinement devices, the insight gained from these experiments is relatively limited. To make further progress in the understanding of plasma turbulence in relation to improved confinement and transport barriers, an extensive experimental and theoretical research programme should be undertaken. The present INTAS project investigates the correlations between on the one hand the occurrence of transport barriers and improved confinement in the tokamaks TEXTOR & T-10 and Tore Supra as well as on the smaller-scale tokamaks FT-2, TUMAN-3M and CASTOR, and on the other hand electric fields, modified magnetic shear and electrostatic and magnetic turbulence using advanced diagnostics with high spatial and temporal resolution. This is done in a strongly coordinated way and exploiting the complementarity of TEXTOR and T-10 and the backup potential of the other tokamaks, which together have all the relevant experimental tools and theoretical expertise. Advanced theoretical models and numerical simulations are used to check the experimental results.За останні десять років було отримано нові режими роботи токамаків, у яких електростатична і магнітна турбулентність, відповідальна за аномальний перенос, могла заглушатися шляхом зовнішнього впливу, і тим самим досягалося поліпшене утримання. Незважаючи на те, що дослідження турбулентності проводилися на багатьох установках, розуміння цих процесів залишається досить обмеженим. Для досягнення подальшого прогресу в розумінні плазмової турбулентності з погляду поліпшеного утримання і транспортних бар'єрів необхідні інтенсивні експериментальні і теоретичні дослідження. Проект INTAS спрямовано на з'ясування кореляції між виникненням транспортних бар'єрів і поліпшеного утримання в токамаках TEXTOR, Т-10 і Tore Supra, а також у токамаках малих розмірів ФТ-2, ТУМАН-3М и CASTOR, з одного боку, і електричними полями, модифікованим магнітним широм і електростатичною і магнітною турбулентністю, з іншого боку, з використанням передових діагностичних засобів з високим просторовим і тимчасовим розділенням. Дослідження проводяться з високим ступенем координації робіт і використанням взаємодоповнюваності установок TEXTOR і Т-10, і можливостей інших токамаків, що в сукупності забезпечить необхідну експериментальну і теоретичну перевірку. Для перевірки експериментальних результатів буде використано нові теоретичні моделі і чисельне моделювання.В последние десять лет были получены новые режимы работы токамаков, в которых электростатическая и магнитная турбулентность, ответственная за аномальный перенос, могла подавляться путём внешнего воздействия, и тем самым достигалось улучшенное удержание. Несмотря на то, что исследования турбулентности проводились на многих установках, понимание этих процессов остаётся весьма ограниченным. Для достижения дальнейшего прогресса в понимании плазменной турбулентности с точки зрения улучшенного удержания и транспортных барьеров необходимы интенсивные экспериментальные и теоретические исследования. Проект INTAS направлен на выяснение корреляции между возникновением транспортных барьеров и улучшенного удержания в токамаках TEXTOR, Т-10 и Tore Supra, а также в токамаках малых размеров ФТ-2, ТУМАН-3М и CASTOR, с одной стороны, и электрическими полями, модифицированным магнитным широм и электростатической и магнитной турбулентностью, с другой стороны, с использованием передовых диагностических средств с высоким пространственным и временным разрешением. Исследования проводятся с высокой степенью координации работ и использованием взаимодополняемости установок TEXTOR и Т-10, и возможностей других токамаков, что в совокупности обеспечит необходимую экспериментальную и теоретическую проверку. Для проверки экспериментальных результатов будут использованы новые теоретические модели и численное моделирование