Le stagioni del Mario

Una rilettura dei testi di Mario Rigoni Stern anche alla luce delle sue riflessioni sulla trasformazione del Veneto e su un modello di sviluppo che sta compromettendo l\u2019equilibrio dell\u2019ambiente in cui viviamo. Interventi di Eraldo Affinati, Linda Cottino, Fernando Bandini, Mario Isnenghi, a cura di Renato Camurri

A Survey of New Temperature-Sensitive, Embryonic-Lethal Mutations in C. elegans: 24 Alleles of Thirteen Genes

To study essential maternal gene requirements in the early C. elegans embryo, we have screened for temperature-sensitive, embryonic lethal mutations in an effort to bypass essential zygotic requirements for such genes during larval and adult germline development. With conditional alleles, multiple essential requirements can be examined by shifting at different times from the permissive temperature of 15°C to the restrictive temperature of 26°C. Here we describe 24 conditional mutations that affect 13 different loci and report the identity of the gene mutations responsible for the conditional lethality in 22 of the mutants. All but four are mis-sense mutations, with two mutations affecting splice sites, another creating an in-frame deletion, and one creating a premature stop codon. Almost all of the mis-sense mutations affect residues conserved in orthologs, and thus may be useful for engineering conditional mutations in other organisms. We find that 62% of the mutants display additional phenotypes when shifted to the restrictive temperature as L1 larvae, in addition to causing embryonic lethality after L4 upshifts. Remarkably, we also found that 13 out of the 24 mutations appear to be fast-acting, making them particularly useful for careful dissection of multiple essential requirements. Our findings highlight the value of C. elegans for identifying useful temperature-sensitive mutations in essential genes, and provide new insights into the requirements for some of the affected loci

Mutants of Bacillus subtilis affected in spore outgrowth

Six mutants of Bacillus subtilis 168 that are temperature-sensitive in spore outgrowth were isolated. The outgrowth process proceeds normally at 35 degrees C, but at the non-permissive temperature (47 degrees C) it is arrested at a specific stage characteristic for each mutant strain. The mutants are not altered in vegetative growth whether at 35 degrees C or at 47 degrees C. They were characterized for their ability to synthesize RNA, proteins and DNA during outgrowth. A mutant defective in spore germination was also isolated; less than 5% of its spores can germinate at any of the temperatures tested. The mutations were mapped by means of transduction and transformation. The isolation of a number of outgrowth mutants which map at different loci and which affect outgrowth at different times is discussed in relation to the regulation of this process

MEMORIA RESISTENTE. LA LOTTA PARTIGIANA A VENEZIA E PROVINCIA NEL RICORDO DEI PROTAGONISTI

Il volume \ue8 l'esito di un progetto di ricerca durato 4 anni, durante i quali un'equipe di ricercatori sotto la supervisione di Albanese e Borghi, hanno raccolto 109 tra interviste e testimonianze di protagonisti della resistenza nel veneziano. Il volume, cui \ue8 allegato un cd-rom con le testimonianze, \ue8 una proposta di lettura di queste interviste da prospettive diverse, con saggi che riflettono sulle novit\ue0 emerse da questi racconti

La Grande Guerra. Storie e parole di giustizia

Attraverso la coltre oscura, tragica e irredimibile della guerra riesce talora a filtrare qualche bagliore di verit\ue0 e dignit\ue0, di \u2018tregue pensose\u2019: atti di riconoscimento del \u2018volto dell\u2019altro\u2019, azioni giuste, oltre la semplice obbedienza all\u2019ordine ricevuto. \uc8 la narrazione letteraria che sa disvelare, nelle \u2018tempeste d\u2019acciaio\u2019 del conflitto di massa e della carneficina industrializzata, non meno che nelle vite di ogni giorno, quanto vi \ue8 di \u2018spiritualmente tipico\u2019: la \u2018dimensione spettrale\u2019, come avrebbe detto lo scrittore Robert Musil, in cui si invera l\u2019\u2018umano\u2019. Si pu\uf2 forse pensare che questa magia di disvelamento, che si rinnova ogni volta nelle grandi narrazioni, non sia destinata a illuminare \u2013 ieri, oggi e sempre \u2013 chi, per professione o per semplice appartenenza al genere umano, voglia debba confrontarsi con la \u2018domanda di giustizia\u2019? E che ad addensare ancor pi\uf9 questa domanda, guidandola verso risposte possibili, non sia proprio lo sguardo di una letteratura che abbia saputo penetrare nell\u2019estremo scempio della guerra, di una guerra che \ue8 stata detta Grande? La Grande Guerra. Storie e parole di giustizia \ue8 ricerca dolente e partecipe di \u2018parole giuste\u2019, ispirate dalle storie di chi o su chi ha attraversato gli abissi di un conflitto mai veramente finito, perch\ue9 coagulo e anticipazione di molti degli orrori dei nostri recenti passati e di un presente che ancora non riesce a liberarsi dallo spettro di Polemos. .Through the obscure, tragic and irredeemable clouds of war, sometimes filters out some gleam of truth and dignity: 'thoughtful truces', acts of recognition of the 'face of the other', right actions, beyond the simple obedience to the order received. It is the literary narrative that knows how to distinguish, in the 'steel storms' of mass conflict and industrial carnage, no less than in everyday lives, what is 'spiritually typical', the 'spectral dimension' ', as the Austrian writer Robert Musil would have said, in which the human mettle can show itself. One may perhaps think that this magic of disarmament, which is renewed every time in the great narratives, is destined to enlighten - yesterday, today and always - those who, by profession and by simple belonging to the human race, desire and must confront themselves. with the 'question of justice'. To thicken even more this great issue, guiding it to possible answers, it is really the look of literature that has been able to penetrate the extreme destruction of the war, of a war that has been called \u2018Great\u2019. The book - a collection of essays written by lawyers, historians, political scientists, literary and film critics, philosophers and writers - is a painful and participatory search for 'right words', inspired by the stories of those who have crossed the abysses of the conflict. A war that can be named Great also because it really never ended as it epitomized and anticipated many of the horrors of our recent past and of a present that still is not able to free itself from the ghost of \u201cPolemos\u201d, from the hostility towards all those who are or may be deemed as \u2018other\u2019, namely as people somewhat looked and treated as adversarie