Эффективность фотодинамической терапии больной ранним центральным раком лёгкого и муковисцидозом

oai:oai.bioph.elpub.ru:article/349The authors describe a clinical observation with full clinical effect after multi-course photodynamic therapy of a patient with central lung cancer and cystic fibrosis using Photoditazine. Photoditazine was administered intravenously at a dose of 0.8 mg/kg 2 hours before the irradiation session. Irradiation parameters: power density – 150 mW/cm2, energy density – 200 J/cm2. In total, 3 courses of photodynamic therapy were performed. As a result of the treatment, a complete regression of the tumor was noted. The patient has been under dynamic observation for 2 years after treatment, no relapse was observed.Авторы описывают клиническое наблюдение с полным клиническим эффектом после многокурсовой фотодинамической терапии больной центральным раком легких и муковисцидозом с использованием фотодитазина. Фотодитазин вводили внутривенно в дозе 0,8 мг/кг за 2 ч до проведения сеанса облучения. Параметры облучения: плотность мощности – 150 мВт/см2, плотность энергии – 200 Дж/см2. Всего было проведено 3 курса фотодинамической терапии. В результате проведенного лечения отмечена полная регрессия опухоли. Пациентка находится под динамическим наблюдением в течение 2 лет после лечения, рецидива не выявлено

Multidrug Resistance of <i>F. tularensis</i> subsp. <i>holarctica</i>, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023

The review provides concise information on the innate ability of cells of the tularemia pathogen, Francisella tularensis subsp. Holarctica, to resist antimicrobials through a variety of mechanisms, leading to its multi-resistance. In total, taking into account new territories, 120 cases of human infection were registered in the Russian Federation in 2022. Epizootic manifestations of the infection of varying degrees of intensity were detected in 58 constituent entities. Against this background, sporadic cases of tularemia in humans were reported in 18 regions of the country. An outbreak of tularemia occurred in the Stavropol Territory; the disease of mild and moderate severity was found in 76 people. The increased incidence of tularemia persists in the Republic of Karelia with severe cases of the disease in the absence of immunoprophylaxis of this infection in the region. A total of 61 cultures of the tularemia pathogen F. tularensis subsp. holarctica, out of which 20 erythromycin-resistant strains were isolated in the Stavropol Territory. In addition, 8 cultures of F. tularensis subsp. mediasiatica from a silt sample and mites Dermacentor silvarum and Haemaphysalis concinna caught in the Republic of Altai were isolated. On the territory of the Russian Federation in 2022, 930 999 people were vaccinated and revaccinated against tularemia. Based on the analysis of the data obtained in 2022, epidemic complications in 2023 in the form of sporadic cases of the disease among the unvaccinated population are most likely to occur in the territories of the Central Federal District – in the Vladimir, Ryazan and Smolensk Regions; Northwestern Federal District – in the Arkhangelsk Region and the Republic of Karelia; Southern Federal District – in the Volgograd and Rostov Regions. The situation in the North Caucasian Federal District will remain tense in the Stavropol Territory; in the Volga Federal District – in the territories of the Saratov Region, as well as in the Kirov Region and the Republic of Mordovia; Ural Federal District – in Khanty-Mansi and Yamalo-Nenets Autonomous Districts; Siberian Federal District – in certain territories of Omsk, Kemerovo, Tomsk, Novosibirsk, Irkutsk Regions, Altai, Krasnoyarsk Territories; in the Far Eastern Federal District, the most intense epizootic activity of natural tularemia foci is in Primorsky Krai

Free-surface flow of a viscoplastic fluid during the filling of a planar channel

The non-Newtonian fluid flow with a free surface occurring during a plane channel filling in the gravity field has been simulated numerically. The mathematical statement of the problem is formulated on the basis of the motion equations, continuity equation, and natural boundary conditions on the free surface with an application of the Herschel-Bulkley rheological model. A traditional mathematical model singularity on the three-phase contact line is eliminated using a slip condition. A numerical algorithm based on the finite-difference method is developed for solving the problem. Regularization of the rheological equation has been carried out using a shock-capturing method for the flow with unyielded regions. A parametric investigation of the flow kinematics and free surface behavior in terms of the governing parameters has been implemented. The flow structures distinguished by the presence of unyielded regions have been demonstrated depending on relation of the viscous, gravity, and plastic forces in the flow

Free-surface flow of a viscoplastic fluid during the filling of a planar channel

The non-Newtonian fluid flow with a free surface occurring during a plane channel filling in the gravity field has been simulated numerically. The mathematical statement of the problem is formulated on the basis of the motion equations, continuity equation, and natural boundary conditions on the free surface with an application of the Herschel-Bulkley rheological model. A traditional mathematical model singularity on the three-phase contact line is eliminated using a slip condition. A numerical algorithm based on the finite-difference method is developed for solving the problem. Regularization of the rheological equation has been carried out using a shock-capturing method for the flow with unyielded regions. A parametric investigation of the flow kinematics and free surface behavior in terms of the governing parameters has been implemented. The flow structures distinguished by the presence of unyielded regions have been demonstrated depending on relation of the viscous, gravity, and plastic forces in the flow

The impact of viscous dissipation on the flow parameters during round tube filling

The fountain non-isothermal flow of a viscous fluid realized during circular pipe filling is investigated. The mathematical basis of the process is formed by the equations of motion, continuity and energy with respective initial and boundary conditions with due account of the temperature dependence of viscosity, the presence of a free boundary, and dissipation of mechanical energy. To solve the problem numerically, a finite difference method is used. Depending on the values defining the dimensionless parameters, the results of parametric studies in temperature, viscosity, dynamic and kinematic characteristics of the flow are shown. Flow patterns for the formulation of problems with different initial and boundary conditions are given. The distributions of velocity and temperature in different cross sections of the pipe and the shape characteristics of the free surface are presented. The separation of flow into the zone of spatial flow in the vicinity of the free surface and one-dimensional flow away from it, and changing the shape of the free boundary, depending on the level of dissipative heating, are demonstrated

The impact of viscous dissipation on the flow parameters during round tube filling

The fountain non-isothermal flow of a viscous fluid realized during circular pipe filling is investigated. The mathematical basis of the process is formed by the equations of motion, continuity and energy with respective initial and boundary conditions with due account of the temperature dependence of viscosity, the presence of a free boundary, and dissipation of mechanical energy. To solve the problem numerically, a finite difference method is used. Depending on the values defining the dimensionless parameters, the results of parametric studies in temperature, viscosity, dynamic and kinematic characteristics of the flow are shown. Flow patterns for the formulation of problems with different initial and boundary conditions are given. The distributions of velocity and temperature in different cross sections of the pipe and the shape characteristics of the free surface are presented. The separation of flow into the zone of spatial flow in the vicinity of the free surface and one-dimensional flow away from it, and changing the shape of the free boundary, depending on the level of dissipative heating, are demonstrated

Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features

The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate the correlation between the enzyme activity in tumors and the levels of expression of the vascular endothelial marker CD34. Methods and results. They were examined spectrophotometrically and by the immunohistochemical method, respectively, in 25 samples of lung cancer tissues. It was shown that its activity in tumors is higher as compared to non-neoplastic adjacent tissues (from 30 to150 nmol/min·mg; in 20 cases from total number). The enzyme activity changes were dependent of the levels of the CD 34, a positive correlation between them was shown (the index of Spearman’s rank correlation, i.e. ρ = 0,668; p<0,05). Conclusion. These findings suggest the possibility of using thymidine phosphorylase as a biochemical marker of angiogenesis, its relationship with the lung cancer phenotype features