PROFICIENT AUTOMATED LIBRARY MANAGEMENT SYSTEM(PALMS): A NEW MODEL FOR PUBLIC LIBRARIES OF PAKISTAN.

The basic objective of this study is to provide a detailed perspective of current situation of public libraries workings and procedures in Karachi (Pakistan) and propose automation strategy with implementation strategy. The study elaborates on the needs of automated library management system components ideally packaging into an ALMS. Differences between available library management system(s) and proposed ALMS have been highlighted as well. This study recommends the development as well as implementation architectures, development technologies, database platforms, required human resources, and Infrastructure (i.e. servers, client machines etc.) for ALMS as a preferred system for public libraries in Karachi,Pakistan.In this study we have proposed a new model for public libraries that refocuses them on the vital task of knowledge management coherent within their communities by way of forming a hub for sharing and disseminating pertinent knowledge. A multi-layered architecture has been proposed for managing information on both local and global levels by creating a connection among multiple instances of system via internet. Statistical data collected by surveying thirty public libraries all over Karachi played a pivotal role in the proposed system design. Different aspects of the system has been identified, quantified and grouped into robust and flexible modules to facilitate the common interactions with the application. The system incorporates modules as pluggable and/or reusable components using MVC design pattern to ease the process of adding, modifying, and/or deleting modules without affecting the integrity of the system. The system features an extremely fast NoSQL database for local storage for real time and offline search (while internet is down). All local databases are combined to form a global database to facilitate the passive users (book readers) of the system. The system also defines four different user-views to provide multi-level access of either the local or global database to its users. Since the horizon of technology is very fragmented, the system is designed to be extremely portable by using Electron framework which enables the application to cover all major platforms Windows, Linux, and Macintosh which are most widely used Operating systems by Institutions

Assessment of menisci and ligamentous injuries of the knee on magnetic resonance imaging: correlation with arthroscopy

OBJECTIVE: To evaluate the validity of MRI, in the assessment of the meniscal and cruciate ligamenteous injuries of the knee joint and comparison with arthroscopic findings. METHODS: A one year prospective cross-sectional study from January 2006 to January 2007, was performed on 50 patients (32 males & 18 females) with knee injury presenting at the orthopedic unit of AKUH. The patients were referred to radiology department for MRI evaluation and arthroscopy. RESULTS: The sensitivity, specificity and accuracy for MRI of the menisci and ligaments were as follows: medial meniscus resulted in 100% sensitivity, 69.27% specificity, 90% PPV, 100% NPV and 92% accuracy: lateral meniscus resulted in 87.5% sensitivity, 88.23% specificity, 77% PPV, 93% NPV and 88% accuracy: anterior cruciate ligament resulted in 86.67% sensitivity, 91.43% specificity, 81% PPV, 94% NPV and 88% accuracy; posterior cruciate ligament resulted in 100% sensitivity, 95.83% specificity,50% PPV, 100 NPV and 96% accuracy. CONCLUSION: Magnetic resonance imaging is a good, accurate and non invasive modality for the assessment of menisci and ligamenteous injuries. It can be used as a first line investigation in patients with soft tissue trauma to knee

Effects of Salinity Stress on Growth and Physio-biochemical Parameters of Three Pea (Pisum sativum L.) Cultivars of Different Maturity Duration

Background: Salinity is one of the leading abiotic stresses that negatively affects the growth of many important food crops and significantly reduces the productivity and yield value.Methods: The present study was conducted to study the effects of NaCl stress on three pea (Pisum sativum) cultivars (Climax, Lina Pak and Pea-267) of different maturity level (Late, early, and mid-season flowering) under In vitro conditions. Two weeks old In vitro grown shoots of three pea cultivars were subjected to stress condition in MS medium supplemented with five levels of NaCl (0, 20, 40, 80 and 100mM NaCl) for one month and different morphological and physio-biochemical traits including length of shoot, number of leaves, shoot biomass, chlorophyll, proline and total phenolic content, total proteins and non-enzymatic antioxidant (DPPH) activities were studied.Results: The results were analyzed using different statistical approaches (ANOVA, MNOVA, PCA, correlation and regression) to identify the tolerance level of each genotype. Shoot length and shoot fresh weight were increased at 20 and 40mM in Climax, while proline content progressively increased with an increase in stress concentration in all the genotypes. Total protein content increased in cvs. Climax and Pea-267 and  decreased in Lina Pak above 20mM and DPPH was increased in Climax and Pea-267 at 20 and 40mM, while in Lina Pak it showed an increase at only 20mM NaCl concentration. According to the results of MNOVA and regression analysis, significant changes occurred in biomass, proline content and DPPH values. A strong positive correlation of shoot dry weight was found with total phenolic and proline content. Maximum value of stress tolerance index was recorded for Climax.Conclusion: Biplot analysis clustered cvs. Climax and Pea-267 cultivars into tolerant group and Lina Pak in sensitive group based on the mean performance of studied parameters to NaCl stress and control treatments

Functional Characterization of Rare RAB12 Variants and Their Role in Musician's and Other Dystonias

Mutations in RAB (member of the Ras superfamily) genes are increasingly recognized as cause of a variety of disorders including neurological conditions. While musician's dystonia (MD) and writer's dystonia (WD) are task-specific movement disorders, other dystonias persistently affect postures as in cervical dystonia. Little is known about the underlying etiology. Next-generation sequencing revealed a rare missense variant (c.586A> G; p.Ile196Val) in RAB12 in two of three MD/WD families. Next, we tested 916 additional dystonia patients; 512 Parkinson's disease patients; and 461 healthy controls for RAB12 variants and identified 10 additional carriers of rare missense changes among dystonia patients (1.1%) but only one carrier in non-dystonic individuals (0.1%; p = 0.005). The detected variants among index patients comprised p.Ile196Val (n = 6); p.Ala174Thr (n = 3); p.Gly13Asp; p.Ala148Thr; and p.Arg181Gln in patients with MD; cervical dystonia; or WD. Two relatives of MD patients with WD also carried p.Ile196Val. The two variants identified in MD patients (p.Ile196Val; p.Gly13Asp) were characterized on endogenous levels in patient-derived fibroblasts and in two RAB12-overexpressing cell models. The ability to hydrolyze guanosine triphosphate (GTP), so called GTPase activity, was increased in mutants compared to wildtype. Furthermore, subcellular distribution of RAB12 in mutants was altered in fibroblasts. Soluble Transferrin receptor 1 levels were reduced in the blood of all three tested p.Ile196Val carriers. In conclusion, we demonstrate an enrichment of missense changes among dystonia patients. Functional characterization revealed altered enzyme activity and lysosomal distribution in mutants suggesting a contribution of RAB12 variants to MD and other dystonias

Spontaneous dural tear leading to intracranial hypotension and tonsillar herniation in Marfan syndrome: a case report

<p>Abstract</p> <p>Background</p> <p>We describe the case of a 38 year old male with Marfan syndrome who presented with orthostatic headaches and seizures.</p> <p>Case Presentation</p> <p>The patient was diagnosed with Spontaneous Intracranial Hypotension secondary to CSF leaks, objectively demonstrated by MR Myelogram with intrathecal contrast. Epidural autologus blood patch was administered at the leakage site leading to significant improvement.</p> <p>Conclusion</p> <p>Our literature search shows that this is the second reported case of a Marfan patient presenting with symptomatic spontaneous CSF leaks along with tonsillar herniation.</p

A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

<p>Abstract</p> <p>Background</p> <p>Hepatitis C can lead to liver fibrosis and cirrhosis. We compared readily available non-invasive fibrosis indexes for the fibrosis progression discrimination to find a better combination of existing non-invasive markers.</p> <p>Methods</p> <p>We studied 157 HCV infected patients who underwent liver biopsy. In order to differentiate HCV fibrosis progression, readily available AAR, APRI, FI and FIB-4 serum indexes were tested in the patients. We derived a new fibrosis-cirrhosis index (FCI) comprised of ALP, bilirubin, serum albumin and platelet count. FCI = [(ALP × Bilirubin) / (Albumin × Platelet count)].</p> <p>Results</p> <p>Already established serum indexes AAR, APRI, FI and FIB-4 were able to stage liver fibrosis with correlation coefficient indexes 0.130, 0.444, 0.578 and 0.494, respectively. Our new fibrosis cirrhosis index FCI significantly correlated with the histological fibrosis stages F0-F1, F2-F3 and F4 (r = 0.818, p < 0.05) with AUROCs 0.932 and 0.996, respectively. The sensitivity and PPV of FCI at a cutoff value < 0.130 for predicting fibrosis stage F0-F1 was 81% and 82%, respectively with AUROC 0.932. Corresponding value of FCI at a cutoff value ≥1.25 for the prediction of cirrhosis was 86% and 100%.</p> <p>Conclusions</p> <p>The fibrosis-cirrhosis index (FCI) accurately predicted fibrosis stages in HCV infected patients and seems more efficient than frequently used serum indexes.</p

Impacts of climate change on the streamflow of a large river basin in the Australian tropics using optimally selected climate model outputs

Climate change affects natural systems, leading to increased acceleration of global water cycle and substantial impacts on the productivity of tropical rivers and the several ecosystem functions they provide. However, the anticipated impacts of climate change in terms of frequency and intensity of extreme events (e.g., droughts and floods) on hydrological systems across regions could be substantially different. This study therefore aims to assess the impacts of climate change on the streamflow of a large river basin located in central Australia (Cooper Creek- Bulloo River Basin). Modified version of the hydrological model Hydrologiska Byråns Vattenbalansavdelning (HBV) was used in this study to generate daily streamflow. This model was first calibrated (2001-2010) and then validated for two independent periods (1993-1997 and 2011-2015). The model depicted a good performance in simulating observed streamflow. Climate projection data from multiple general circulation models (ACCESS1.0, CanESM2, CESM1-CAM5, CNRM-CM5, GFDL-ESM2M, HadGEM2-CC, MIROC5, NorESM1-M, ACCESS1-0, ACCESS1-3, CCSM4, CNRM-CM5, CSIRO-Mk3.6, GFDL-CM3, GFDL-ESM2M, HadGEM2, MIROC5, MPI-ESM-LR, and NorESM1-M) in various forms (raw, statistically downscaled, dynamically downscaled, and bias adjusted) were considered in this study. Results showed that three high resolution dynamically downscaled and bias adjusted models (ACCESS1-3, CNRM-CM5, and MPI-ESM-LR) from Terrestrial Ecosystem Research Network (TERN) dataset (v1.0.2) have better performance than other models considered, that is, in terms of capturing observed precipitation over the basin. Future climate projections of ensemble of these three models forced with RCP 4.5 and RCP 8.5 emission scenarios were then used to generate streamflow for 2050s (2040-2069) and 2080s (2070-2099). Results of the study indicated that mean annual precipitation was projected to decrease by up to -8% in 2050s and temperature was projected to increase by up to 4.66 °C in 2080s under the average and extreme emission scenarios, respectively. Mean annual, mean seasonal (December-February, March-May, June-August, September-November), and mean monthly streamflow were projected to decrease under different emission scenarios in 2050s and 2080s. These results indicate decreased water availability in the future as well as water cycle intensification. These changes in streamflow might have impacts on agriculture, natural ecosystem, and could lead to water restrictions. The outcome of this study can directly feed into frameworks for sustainable management of water resources and support adaptation strategies that rely on science and policy to improve water resources allocation in the region

Application of a Conceptual Hydrological Model for Streamflow Prediction Using Multi-Source Precipitation Products in a Semi-Arid River Basin

Management of the freshwater resources in a sustained manner requires the information and understanding of the surface water hydrology and streamflow is of key importance in this nexus. This study evaluates the performance of eight different precipitation products (APHRODITE, CHRS CCS, CHRS CDR, CHIRPS, CPC Global, GPCC, GPCP, and PERSIANN) for streamflow prediction in two sub-catchments (Chirah and Dhoke Pathan) of the data-scarce Soan River Basin (SRB) in Pakistan. A modified version of the hydrological model HBV (Hydrologiska Byråns Vattenbalansavdelning) known as HBV-light was used to generate streamflow. The model was separately calibrated and validated with observed and estimated precipitation data for streamflow simulation with optimized parameterization. The values of R2, NSE, KGE and PBIAS obtained during the calibration (validation) period for the Chirah sub-catchment were 0.64, 0.64, 0.68 and −5.6% (0.82, 0.81, 0.88 and 7.4%). On the other hand, values of R2, NSE, KGE, and PBIAS obtained during the calibration (validation) period for the Dhoke Pathan sub-catchment were 0.85, 0.85, 0.87, and −3.4% (0.82, 0.7, 0.73 and 6.9%). Different ranges of values were assigned to multiple efficiency evaluation metrics and the performance of precipitation products was assessed. Generally, we found that the performance of the precipitation products was improved (higher metrics values) with increasing temporal and spatial scale. However, our results showed that APHRODITE was the only precipitation product that outperformed other products in simulating observed streamflow at both temporal scales for both Chirah and Dhoke Pathan sub-catchments. These results suggest that with the long-term availability of continuous precipitation records with fine temporal and spatial resolutions, APHRODITE has the high potential to be used for streamflow prediction in this semi-arid river basin. Other products that performed better were GPCC, GPCP, and CHRS CCS; however, their scope was limited either to one catchment or a specific time scale. These results will also help better understand surface water hydrology and in turn, would be useful for better management of the water resources

Characteristics of interstage death after discharge from stage I palliation

BACKGROUND: Interstage mortality (IM) remains high for patients with single-ventricle congenital heart disease (SVCHD) in the period between Stage 1 Palliation (S1P) and Glenn operation. We sought to characterize IM. METHODS: This was a descriptive analysis of 2184 patients with SVCHD discharged home after S1P from 60 National Pediatric Cardiology Quality Improvement Collaborative sites between 2008 and 2015. Patients underwent S1P with right ventricle-pulmonary artery conduit (RVPAC), modified Blalock-Taussig-Thomas shunt (BTT), or Hybrid; transplants were excluded. RESULTS: IM occurred in 153 (7%) patients (median gestational age 38 weeks, 54% male, 77% white), at 88 (IQR 60,136) days of life, and 39 (IQR 17,84) days after hospital discharge; 13 (8.6%) occurred ≤ 30 days after S1P. The mortality rate for RVPAC was lower (5.2%; 59/1138) than BTT (9.1%; 65/712) and Hybrid (20.1%; 27/134). More than half of deaths occurred at home (20%) or in the emergency department (33%). The remainder occurred while inpatient at center of S1P (cardiac intensive care unit 36%, inpatient ward 5%) or at a different center (5%). Fussiness and breathing problems were most often cited as harbingers of death; distance to surgical center was the biggest barrier cited to seeking care. Cause of death was unknown in 44% of cases overall; in the subset of patients who underwent post-mortem autopsy, the cause of death remained unknown in 30% of patients, with the most common diagnosis being low cardiac output. CONCLUSIONS: Most IM occurred in the outpatient setting, with non-specific preceding symptoms and unknown cause of death. These data indicate the need for research to identify occult causes of death, including arrhythmia