Hamiltonians separable in cartesian coordinates and third-order integrals of motion

We present in this article all Hamiltonian systems in E(2) that are separable in cartesian coordinates and that admit a third-order integral, both in quantum and in classical mechanics. Many of these superintegrable systems are new, and it is seen that there exists a relation between quantum superintegrable potentials, invariant solutions of the Korteweg-De Vries equation and the Painlev\'e transcendents.Comment: 19 pages, Will be published in J. Math. Phy

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline.

Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these treatment modalities. Here, we used positron emission tomography and the α-[11C]methyl-L-tryptophan tracer to examine the changes in brain regional serotonin synthesis capacity in OCD patients following treatment with CBT or SSRI treatment. Sixteen medication-free OCD patients were randomly assigned to 12 weeks of either CBT or sertraline treatment. Pre-to-post treatment changes in the α-[11C]methyl-L-tryptophan brain trapping constant, K* (ml/g/min), were assessed as a function of symptom response, and correlations with symptom improvement were examined. Responders/partial responders to treatment did not show significant changes in relative regional tracer uptake; rather, in responders/partial responders, 12 weeks of treatment led to serotonin synthesis capacity increases that were brain-wide. Irrespective of treatment modality, baseline serotonin synthesis capacity in the raphe nuclei correlated positively with clinical improvement. These observations suggest that, for some patients, successful remediation of OCD symptoms might be associated with greater serotonergic tone

More than Mechanisms: Shifting Ideologies for Asset-Based Learning in Engineering Education

Learning spaces, the practices in which people engage, and the representations they use are ideological. Ideologies are coherent constellations of values, beliefs, and practices that impose order on how disciplines like engineering operate. Historically, engineering spaces have been dominated by a relatively technocratic, rationalistic, and exclusionary ideology, but more recent attention to asset-based approaches to engineering education offers transformative promise. Asset-based ideologies can reshape images of legitimized engineering practice, recasting engineering education to disrupt dominant exclusionary ideologies. This paper describes an assets-based learning space, SETC, that recaptures the imagination of engineering for technological and social change. Drawing from extensive ethnographic observational data, interviews, and artifacts produced in SETC, we describe aspects of this learning space, including the use of representations and practices that specifically support expansive forms of engineering practiced by youth of color. We also explore how SETC’s commitment to antiracist and liberatory practices, including shifting relationships to technology and engineering design in service of enhancing life, manifests in its transformative mission to design programs and activities for youth that disrupt dominant ideologies. SETC centers making and tinkering as legitimate expressions of engineering, and we present a case of a youth participant to illustrate the rich engineering learning that the space makes possible. The case features Naeem engineering a gear-based project that expresses his interpretation of Black Lives Matter. Situated in his long history in the learning space, we explore how youth’s interactions with conventionalized representations—which serve to maintain dominant ideologies—are enhanced by asset-based commitments. This paper contributes specific recommendations for designing spaces for new ideologies, making engineering education more equitable for youth of color while also expanding notions of what engineering is and the forms that it can take

Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein

Oligodendrocytes (OLs) extend arborized processes that are supported by microtubules (MTs) and microfilaments. Little is known about proteins that modulate and interact with the cytoskeleton during myelination. Several lines of evidence suggest a role for 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) in mediating process formation in OLs. In this study, we report that tubulin is a major CNP-interacting protein. In vitro, CNP binds preferentially to tubulin heterodimers compared with MTs and induces MT assembly by copolymerizing with tubulin. CNP overexpression induces dramatic morphology changes in both glial and nonglial cells, resulting in MT and F-actin reorganization and formation of branched processes. These morphological effects are attributed to CNP MT assembly activity; branched process formation is either substantially reduced or abolished with the expression of loss-of-function mutants. Accordingly, cultured OLs from CNP-deficient mice extend smaller outgrowths with less arborized processes. We propose that CNP is an important component of the cytoskeletal machinery that directs process outgrowth in OLs

Fundamental limitations on "warp drive" spacetimes

"Warp drive" spacetimes are useful as "gedanken-experiments" that force us to confront the foundations of general relativity, and among other things, to precisely formulate the notion of "superluminal" communication. We verify the non-perturbative violation of the classical energy conditions of the Alcubierre and Natario warp drive spacetimes and apply linearized gravity to the weak-field warp drive, testing the energy conditions to first and second order of the non-relativistic warp-bubble velocity. We are primarily interested in a secondary feature of the warp drive that has not previously been remarked upon, if it could be built, the warp drive would be an example of a "reaction-less drive". For both the Alcubierre and Natario warp drives we find that the occurrence of significant energy condition violations is not just a high-speed effect, but that the violations persist even at arbitrarily low speeds. An interesting feature of this construction is that it is now meaningful to place a finite mass spaceship at the center of the warp bubble, and compare the warp field energy with the mass-energy of the spaceship. There is no hope of doing this in Alcubierre's original version of the warp-field, since by definition the point in the center of the warp bubble moves on a geodesic and is "massless". That is, in Alcubierre's original formalism and in the Natario formalism the spaceship is always treated as a test particle, while in the linearized theory we can treat the spaceship as a finite mass object. For both the Alcubierre and Natario warp drives we find that even at low speeds the net (negative) energy stored in the warp fields must be a significant fraction of the mass of the spaceship.Comment: 18 pages, Revtex4. V2: one reference added, some clarifying comments and discussion, no physics changes, accepted for publication in Classical and Quantum Gravit

A Novel Inhibitory Mechanism of Mitochondrion-Dependent Apoptosis by a Herpesviral Protein

Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel viral mitochondrial anti-apoptotic protein (vMAP) of murine γ-herpesvirus 68 (γHV-68) interacts with Bcl-2 and voltage-dependent anion channel 1 (VDAC1) in a genetically separable manner. The N-terminal region of vMAP interacted with Bcl-2, and this interaction markedly increased not only Bcl-2 recruitment to mitochondria but also its avidity for BH3-only pro-apoptotic proteins, thereby suppressing Bax mitochondrial translocation and activation. In addition, the central and C-terminal hydrophobic regions of vMAP interacted with VDAC1. Consequently, these interactions resulted in the effective inhibition of cytochrome c release, leading to the comprehensive inhibition of mitochondrion-mediated apoptosis. Finally, vMAP gene was required for efficient γHV-68 lytic replication in normal cells, but not in mitochondrial apoptosis-deficient cells. These results demonstrate that γHV-68 vMAP independently targets two important regulators of mitochondrial apoptosis-mediated intracellular innate immunity, allowing efficient viral lytic replication

Superintegrability with third order invariants in quantum and classical mechanics

We consider here the coexistence of first- and third-order integrals of motion in two dimensional classical and quantum mechanics. We find explicitly all potentials that admit such integrals, and all their integrals. Quantum superintegrable systems are found that have no classical analog, i.e. the potentials are proportional to \hbar^2, so their classical limit is free motion.Comment: 15 page

Arduous implementation: Does the Normalisation Process Model explain why it's so difficult to embed decision support technologies for patients in routine clinical practice

Background: decision support technologies (DSTs, also known as decision aids) help patients and professionals take part in collaborative decision-making processes. Trials have shown favorable impacts on patient knowledge, satisfaction, decisional conflict and confidence. However, they have not become routinely embedded in health care settings. Few studies have approached this issue using a theoretical framework. We explained problems of implementing DSTs using the Normalization Process Model, a conceptual model that focuses attention on how complex interventions become routinely embedded in practice.Methods: the Normalization Process Model was used as the basis of conceptual analysis of the outcomes of previous primary research and reviews. Using a virtual working environment we applied the model and its main concepts to examine: the 'workability' of DSTs in professional-patient interactions; how DSTs affect knowledge relations between their users; how DSTs impact on users' skills and performance; and the impact of DSTs on the allocation of organizational resources.Results: conceptual analysis using the Normalization Process Model provided insight on implementation problems for DSTs in routine settings. Current research focuses mainly on the interactional workability of these technologies, but factors related to divisions of labor and health care, and the organizational contexts in which DSTs are used, are poorly described and understood.Conclusion: the model successfully provided a framework for helping to identify factors that promote and inhibit the implementation of DSTs in healthcare and gave us insights into factors influencing the introduction of new technologies into contexts where negotiations are characterized by asymmetries of power and knowledge. Future research and development on the deployment of DSTs needs to take a more holistic approach and give emphasis to the structural conditions and social norms in which these technologies are enacte