Hypothesis on the pathophysiology of small intestinal strangulation by a pedunculated lipoma

SummaryThe current hypothesis proposed for strangulation of small intestine by a pedunculated lipoma in horses involves movement of the lipoma around the small intestine until it loops through its own pedicle. This mechanism is difficult to demonstrate during surgical correction. The objective was to examine an alternative explanation for strangulation by pedunculated lipomas that is logical and consistent with intraoperative findings by the analysis of the anatomical features of 11 cases of lipoma strangulation in horses. In the proposed hypothesis, the stalk of the lipoma is tensed by the weight of the lipoma alone or by external forces on it from adjacent intestine. This produces a slit‐like aperture formed by the stalk and the contiguous mesentery. One or more loops of intestine pass across the lateral edge of the stalk before turning into this aperture, either because of lack of space in the abdominal cavity or through the effects of peristalsis. The weight of the intestine itself causes the loop to 'fall' into the aperture and become entrapped. This creates a half‐hitch knot in which the loop of intestine uses the lipoma pedicle as a 'post' around which it becomes strangulated. It was concluded that the proposed hypothesis differs from the existing one by requiring intestinal movement to create the strangulation, which is more plausible than the current proposal that the strangulation is caused by movement of the lipoma itself. It is also more consistent with surgical findings

A 4-pronged approach to foster healthy aging in older adults.

Monitoring patients\u27 health, mobility, mentation, and ability to maintain social connections can help you promote healthy aging for your older patients

Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography

Optical coherence tomography (OCT) angiography (OCTA) is a non-invasive tool for the in-vivo study of the intraretinal vascular network. It is based on the analysis of motion particles within the retina to reconstruct the paths followed by the erythrocytes, i.e. retinal capillaries. To date, qualitative and quantitative information are based on the morphological features disclosed by retinal capillaries. In the present study, we proposed new quantitative functional metrics, named Total Flow Intensity (TFI), Active Flow Intensity (AFI), and Volume-related Flow Intensity (VFI), based on the processing of the blood flow signal detected by OCTA. We studied these metrics in a cohort of healthy subjects, and we assessed their clinical utility by including a cohort of age-matched patients affected by Stargardt disease. Moreover, we compared TFI, AFI, and VFI to the widely used vessel density (VD) parameter. TFI, AFI, and VFI were able to describe in detail the different properties of the retinal vascular compartment. In particular, TFI was intended as the overall amount of volumetric retinal blood flow. AFI represented a selective measure of voxels disclosing blood flow signal. VFI was developed to put in relationship the volumetric blood flow information with the not vascularized retinal volume. In conclusion, TFI, AFI, and VFI were proposed as feasible functional OCTA biomarkers based on the analysis of retinal blood flow signal

Three-dimensional printed polycaprolactone-microcrystalline cellulose scaffolds

Microcrystalline cellulose (MCC) is proposed in this study as an additive in polycaprolactone (PCL) matrices to obtain three-dimensional (3D) printed scaffolds with improved mechanical and biological properties. Improving the mechanical behavior and the biological performance of polycaprolactone-based scaffolds allows to increase the potential of these structures for bone tissue engineering. Different groups of samples were evaluated in order to analyze the effect of the additive in the properties of the PCL matrix. The concentrations of MCC in the groups of samples were 0, 2, 5, and 10% (w/w). These combinations were subjected to a thermogravimetric analysis in order to evaluate the influence of the additive in the thermal properties of the composites. 3D printed scaffolds were manufactured with a commercial 3D printer based on fused deposition modelling. The operation conditions have been established in order to obtain scaffolds with a 0/90° pattern with pore sizes between 450 and 500 µm and porosity values between 50 and 60%. The mechanical properties of these structures were measured in the compression and flexural modes. The scaffolds containing 2 and 5% MCC have higher flexural and compression elastic modulus, although those containing 10% do not show this reinforcement effect. On the other hand, the proliferation of sheep bone marrow cells on the proposed scaffolds was evaluated over 8 days. The results show that the proliferation is significantly better (p < 0.05) on the group of samples containing 2% MCC. Therefore, these scaffolds (PCL:MCC 98:2) have suitable properties to be further evaluated for bone tissue engineering applications

Black Rings in Taub-NUT and D0-D6 interactions

We analyze the dynamics of neutral black rings in Taub-NUT spaces and their relation to systems of D0 and D6 branes in the supergravity approximation. We employ several recent techniques, both perturbative and exact, to construct solutions in which thermal excitations of the D0-branes can be turned on or off, and the D6-brane can have $B$-fluxes turned on or off in its worldvolume. By explicit calculation of the interaction energy between the D0 and D6 branes, we can study equilibrium configurations and their stability. We find that although D0 and D6 branes (in the absence of $B$ fields, and at zero temperature) repeal each other at non-zero separation, as they get together they go over continuosly to an unstable bound state of an extremal singular Kaluza-Klein black hole. We also find that, for $B$-fields larger than a critical value, or sufficiently large thermal excitation, the D0 and D6 branes form stable bound states. The bound states with thermally excited D0 branes are black rings in Taub-NUT, and we provide an analysis of their phase diagram.Comment: 50 pages, 8 figures; v3: minor changes and references added; v4: improved figs. 7 and 8, matches with published versio

D-brane Construction of the 5D NHEK Dual

Extremal but non-supersymmetric charged black holes with SU(2)_L spin in IIB string theory compactified to five dimensions on K^3 x S^1 are considered. These have a near-horizon or NHEK region with an enhanced SL(2,R)_L conformal symmetry. It is shown that the NHEK geometry has a second, inequivalent, asymptotically flat extension in which the radius of the S^1 becomes infinite but the radius of the angular circles of SU(2)_L orbits approach a constant. The asymptotic charges associated to the second solution identify it as a 5D D1-D5-Taub-NUT black string with certain nonzero worldvolume charge densities, temperatures and chemical potentials. The dual of the NHEK geometry is then identified as an IR limit of this wrapped brane configuration.Comment: 11 page

Synchronized onset of nuclear and cell surface modifications in U937 cells during apoptosis

In this study we investigated the relationship between nuclear and cell surface modifications (i.e. blebbing, phosphatidylserine [PS] and sugar residues exposure) in a monocytic cell line, U937, during apoptosis induced by oxidative stress (1mM H2O2) or inhibition of protein synthesis (10 mg/ml puromycin). Dying cells were simultaneously observed for nuclear modifications, presence of superficial blebs and plasma membrane alterations. Morphological analysis performed by conventional fluorescence microscopy, or by transmission and scanning electron microscopy showed that the courses of nuclear and membrane alterations occured concomitantly, but the phenotype was dependent on the stage of the apoptotic process and the type of apoptogenic inducer used. The progression of apoptosis in U937 cells beyond early stages resulted in the extensive formation of blebs which concomitantly lost some typical markers of apoptosis, such as PS and sugar residues. Therefore, the modality by which the nucleus condenses, or the amount and the pattern of distribution of PS on the cell surface were, for each cell line, strictly related to the apoptogenic inducer. The morphological data reported in the present paper should lead to a more precise quantification of apoptosis by improving the detection of apoptotic cells in vivo (i.e. in tissue, organs), which is a crucial point in the evaluation of efficiency of antiproliferative drugs, such as antiblastic or immunosuppressive compounds

Smooth geometries with four charges in four dimensions

A class of axially symmetric, rotating four-dimensional geometries carrying D1, D5, KK monopole and momentum charges is constructed. The geometries are found to be free of horizons and singulaties, and are candidates to be the gravity duals of microstates of the (0,4) CFT. These geometries are constructed by performing singularity analysis on a suitably chosen class of solutions of six-dimensional minimal supergravity written over a Gibbons-Hawking base metric. The properties of the solutions raise some interesting questions regarding the CFT.Comment: 1+32 pages, LaTeX, v2: references added, typographical errors correcte