A brief early intervention for adolescent depression that targets emotional mental images and memories: protocol for a feasibility randomised controlled trial (IMAGINE trial)

This is the final version of the article. Available from BioMed Central via the DOI in this record.Background: Adolescent depression is common and impairing. There is an urgent need to develop early interventions to prevent depression becoming entrenched. However, current psychological interventions are difficult to access and show limited evidence of effectiveness. Schools offer a promising setting to enhance access to interventions, including reducing common barriers such as time away from education. Distressing negative mental images and a deficit in positive future images, alongside overgeneral autobiographical memories, have been implicated in depression across the lifespan, and interventions targeting them in adults have shown promise. Here, we combine techniques targeting these cognitive processes into a novel, brief psychological intervention for adolescent depression. This feasibility randomised controlled trial will test the feasibility and acceptability of delivering this imagery-based cognitive behavioural intervention in schools. Methods/design: Fifty-six adolescents (aged 16-18) with high symptoms of depression will be recruited from schools. Participants will be randomly allocated to the imagery-based cognitive behavioural intervention (ICBI) or the control intervention, non-directive supportive therapy (NDST). Data on feasibility and acceptability will be recorded throughout, including data on recruitment, retention and adherence rates as well as adverse events. In addition, symptom assessment will take place pre-intervention, post-intervention and at 3-month follow-up. Primarily, the trial aims to establish whether it is feasible and acceptable to carry out this project in a school setting. Secondary objectives include collecting data on clinical measures, including depression and anxiety, and measures of the mechanisms proposed to be targeted by the intervention. The acceptability of using technology in assessment and treatment will also be evaluated. Discussion: Feasibility, acceptability and symptom data for this brief intervention will inform whether an efficacy randomised controlled trial is warranted and aid planning of this trial. If this intervention is shown in a subsequent definitive trial to be safe, clinically effective and cost-effective, it has potential to be rolled out as an intervention and so would significantly extend the range of therapies available for adolescent depression. This psychological intervention draws on cognitive mechanism research suggesting a powerful relationship between emotion and memory and uses imagery as a cognitive target in an attempt to improve interventions for adolescent depression. Trial registration: ISRCTN85369879.This study represents independent research from a Clinical Doctoral Research Fellowship (Dr Victoria Pile, ICA-CDRF-2015-01-007) supported by the National Institute for Health Research and Health Education England

Metode Partisipatif dalam Penyusunan Peraturan Desa di Desa Pitu Maluku Utara

Pengabdian masyarakat dilaksanakan bersama mitra Badan Usaha Milik Desa (BUMDes) Wisata Pantai Desa Pitu Kecamatan Tobelo Tengah Kabupaten Halmahera Utara dengan tujuan a) meningkatkan tata kelola BUMDes yang lebih baik; b) meningkatkan pengetahuan badan pengerus BUMDes dan stakeholder terkait. Metode kegiatan pengabdian kepada masyarakat dilaksanakan sebagai berikut a) metode cerama Permendagri No. 111 Tahun 2014 Tentang Pedoman Teknis Peraturan di Desa; b) Praktik pembuatan peraturan desa tentang pungutan wisata pantai; c) Praktik pembuatan standard operasional prosedur; d) penataan administrasi BUMDes. Seluruh kegiatan pengabdian masyarakat turut berpartisipasi pengurus BUMDes, Pemerintah desa, BPD, pemilik warung dan stakeholder terkait. Hasil Program Kemitraan Masyarakat yang diperoleh Mitra BUMDes sebagai berikut; a) Tersedianya Peraturan Desa tentang Pungutan Wisata Pantai; b) Tersedia Standar Layanan Publik; c) Terciptanya tata kelola Administrasi Bumdes semakin mandiri

An image overlay system with enhanced reality for percutaneous therapy performed inside CT scanner

Abstract. We describe a simple, safe, and inexpensive image overlay system to assist surgical interventions inside a conventional CT scanner. The overlay system is mounted non-invasively on the gantry of the CT scanner and it consists of a seven degrees-of-freedom passive mounting arm, a flat LCD display, and a light brown acrylic plate as a half mirror. In a pre-operative calibration process, the display, half-mirror, and imaging plane of the scanner are spatially registered by imaging a triangular calibration object. Following the calibration, the patient is brought into the scanner, an image is acquired and sent to the overlay display via DICOM transfer. Looking at the patient through the half-mirror, the CT image appears to be floating inside the patient in correct size and position. This vision enables the physician to see both the surface and the inside of the patient at the same time, which can be utilized in guiding a surgical intervention. The complete system fits into a carry-on suitcase (except the mounting adapter), it is easy to calibrate, mounts non-invasively on the scanner, without utilizing vendor-specific features of he scanner.

Males at-risk for the BRCA1-gene, the psychological impact

In recent literature the psychological impact of predictive DNA-testing for Hereditary Breast and Ovarian Cancer (HBOC) for male individuals at-risk has not been considered. We have observed that confrontation with the hereditary nature of breast/ovarian cancer does have a psychological impact on males at-risk. From the first Dutch family for whom predictive DNA-testing for HBOC became an option, four males started the testing protocol with the inclusion of pre-test genetic and psychological counselling and psychological follow-up. They all postponed appointments and only one took the test. During counselling of the men, the main focus of attention was on the impact of the past and future (possible) deaths and serious illnesses of female relatives. They tended to deny or minimise the emotional impact of the occurrence of HBOC in their personal life and their future. They avoided discussion about their emotions and focused upon the medical implications of the disorder for their female relatives. It is important to understand the underlying conflicts which lead to warding off the test in males at risk, in order to offer adequate genetic counselling and to enable the males to better cope with the hereditary disorder in the famil