55 research outputs found
SEPARATION OF OPTICAL ISOMERS VIA DIASTEREOISOMERIC SALT FORMATION
The optical resolution processes were systematically investigated. The optimum of the
parameters of the diastereoisomeric salt formation can be determined by using a thermodynamic
equilibrium model. Based upon the conformational analysis of the structure for diastereo
isomeric salts, a new method has been elaborated for designing optical resolutions
Synthesis, Characterization and Application of Platinum(II) Complexes Incorporating Racemic and Optically Active 1-Phenyl-1,2,3,6-Tetrahydrophosphinine Ligand
An efficient resolution method was elaborated for the preparation of (+)-4-chloro-5-methyl-1-phenyl-1,2,3,6-tetrahydrophosphinine oxide using the acidic Ca2+ salt of (–)-O,O-di-p-toluoyl-(2R,3R)-tartaric acid. Crystal structure of the diastereomeric complex was evaluated by single crystal X-ray analysis. Beside this, the absolute P-configuration was also determined by a CD spectroscopic study including theoretical calculations. The tetrahydrophosphinine oxide was then converted to the corresponding platinum complex whose stereostructure was investigated by high level quantum chemical calculations. The Pt-complex was tested as catalyst in the hydroformylation of styrene
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