Antioxidant capacity and sugar content of honey from Blue Nile State, Sudan

This study aimed to evaluate antioxidant capacity of honey samples that were collected from Blue Nile State, Sudan by determining total phenolic content (TPC) and total flavonoids content (TFC). Antioxidant activities were evaluated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity and ferric reducing power assay (FRAP). High-Performance Liquid Chromatography (HPLC) was used for the determination of sugars content. The results showed that the highest TPC was (85.7±1 mg GAE /100g), the highest TFC was found to be (55.14 ± 1.09 mg QE /100g) using quercetin equivalent (QE) as standard and the inhibition value of (DPPH) was (52.93 ± 0.44%). The FRAP showed the highest value of (281 μM TE/100g), also the results indicated that the honey contained fructose (38.6 ± 1.8 g/100g - 42.9 ± 1.3 gL100g), and glucose (30.4 ± 0.75 - 31.7 ± 0.68 g/100g). Protein content was found to be ranging between and 0.60% and 1.04%. In conclusion, the results showed that honey is a good source of antioxidants due to the presence of phenolic compounds, flavonoids and carotene. Also, an excellent source of the simple reducing sugars

CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA: PREVALENCE AND CLINICAL CHARACTERISTICS

Backround: The aim of this study was to explore the co-morbidity between Major Depressive Disorder (MDD) and Schizophrenia (SZ) among a large number of patients describing their clinical characteristics and rate of prevalence. Subjects and methods: A cohort-study was carried out on 396 patients affected by MDD and SZ who consecutively attended the Department of Psychiatry, Rumeilah Hospital in Qatar. We employed the World Health Organization - Composite International Diagnostic Interview (WHO CIDI) and the Structured Clinical Interview for DSM-5 (SCID-5) for diagnoses. Patients were also grouped in MDD patients with and without co-morbid SZ (MDD vs MDD/SZ) for comparisons. Results: A total of 396 subjects were interviewed. MDD patients with comorbid SZ (146(36.8%)) were 42.69±14.33 years old whereas MDD without SZ patients (250 (63.2%)) aged 41.59±13.59. Statistically significant differences between MDD with SZ patients and MDD without SZ patients were: higher BMI (Body Mass Index) (p=0.025), lower family income (p=0.004), higher rate of cigarette smoking (p<0.001), and higher level of consanguinity (p=0.023). Also, statistically significant differences were found in General Health Score (p=0.017), Clinical Global Impression-BD Score (p=0.042), duration of illnesses (p=0.003), and Global Assessment of Functioning (p=0.012). Rates of anxiety dimensions (e.g.: general anxiety, agoraphobia, somatisation, etc.), mood dimensions (e.g.: major depression, mania, oppositional defiant behaviour, Bipolar disorder), Attention Deficit Hyperactivity Disorder, psychotic and personality dimensions were higher among MDD with SZ patients than MDD without SZ. Conclusion: This study confirms that MDD with SZ is a common comorbidity especially among patients reporting higher level of consanguinity. MDD/SZ comorbidity presents unfavourable clinical characteristics and higher levels of morbidity at rating scales

Screening of some sorghum genotypes for resistance to sorghum midge, Stenodiplosis (= Contarinia) sorghicola Coqillet (diptera: Cecidomyiidae) under gedarif rainfed conditions

Preliminary experiments were conducted at Northern area, Gedarif State during seasons of 2002-03, 2006-07.Where as advanced trials during 2008/2009 to 2012/2013 at northern and Southern areas. The objective was to evaluate selected sorghum genotypes for sorghum midge resistance. A total of 3000 accessions were obtained from Gene Bank Resources. Resistant genotype, DJ 6514 (Resistant Check already released in 2007) was obtained from International Crops Research Institute for the Semi-Arid Tropics (ICRISAT). Result showed that the midge damage rating was significantly different among genotypes. The midge damage rating scores ranged between, 1.3- 8.6; 1.1- 9.2; 1.4- 9.0; 1.1 – 9.4; and 1.2- 9.2 for all seasons (2008/09; 2009/10; 2010/11; 2011/12 and 2012/13). However, the lowest midge damage rating was recorded by DJ 6514 (Resistant check), followed by P₁ 570162 (Hag Abbakar); GBM 30 (Early Feterita); Wad Baco; and Safra (1.4; 1.5; 1.5, 1.6 and 1.7), respectively. Genotypes, P₁ 570162 (Hag Abbakar); GBM 30 (Early Feterita); Wad Baco; Safra and Harerai showed lowest % yield loss and performed similar to the resistant check (14.2; 14.5; 14.5; 17.0 and 17.3%), respectively. The combined analysis showed that a significant difference was observed between genotypes. The genotypes were significantly different in panicle types, compact and semi-compact headed genotypes showed lower % glumes coverage (1.3- 4.5%), while semi-compact headed genotypes ranged between 5.5 – 7.8%. Genotypes, Wad Baco; P₁ 570162 (Hag Abbakar); GBM 30 (Early Feterita); Safra; Wad Ahmed; Harerai and Wad Akar showed the shortest glumes coverage (1.3; 1.3; 1.5; 1.5; 1.6; 1.7 and 1.8 %). Compact headed genotypes recorded lowest midge density (6.5 adults/ 5 heads), while the semi-compact headed genotypes were recorded 15.7 adults/ 5 heads compared with others types of heads

Genetic diversity of hepatitis E virus (HEV) in imported and domestic camels in Saudi Arabia

Camels gained attention since the discovery of MERS-CoV as intermediary hosts for potentially epidemic zoonotic viruses. DcHEV is a novel zoonotic pathogen associated with camel contact. This study aimed to genetically characterize DcHEV in domestic and imported camels in Saudi Arabia. DcHEV was detected by RT-PCR in serum samples, PCR-positive samples were subjected to sequencing and phylogenetic analyses. DcHEV was detected in 1.77% of samples with higher positivity in domestic DCs. All positive imported dromedaries were from Sudan with age declining prevalence. Domestic DcHEV sequences clustered with sequences from Kenya, Somalia, and UAE while imported sequences clustered with one DcHEV isolate from UAE and both sequences clustered away from isolates reported from Pakistan. Full-genome sequences showed 24 amino acid difference with reference sequences. Our results confirm the detection of DcHEV in domestic and imported DCs. Further investigations are needed in human and camel populations to identify DcHEV potential zoonosis threat

May Measurement Month 2017: an analysis of blood pressure screening in Sudan-Northern Africa and Middle East

Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. Sudan has the second highest prevalence of hypertension in North Africa. One in four people with a non-communicable disease has hypertension. May Measurement Month (MMM) is a global initiative, aimed at raising awareness of high BP to act as a temporary solution to the lack of screening programs worldwide. The MMM screening survey provided an opportunity to correlate between unique risk factors and BP levels among Sudanese population. Such an approach allows for directing efforts towards setting the appropriate preventive measures as opposed to disease treatment. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2017. Blood pressure measurement, the definition of hypertension and statistical analysis followed the standard MMM protocol. The study was conducted at 100 sites distributed in four states: Khartoum, Gezira, Blue Nile, and Kassala. Overall, a total of 44 413 participants were enrolled in the survey. After imputation, 7332 out of 44 118 participants with an available mean of the second and third readings had hypertension (16.6%). A total of 6956 (15.9%) participants were found to have hypertension of the 43 742 who were not receiving treatment. Among participants who were on treatment, 155 out of 374 (41.3%) had uncontrolled BP. After adjusting for age and sex, systolic and diastolic BP's were significantly higher in those receiving antihypertensive treatment, with a previous history of stroke and with elevated body mass index. Systolic BP was significantly higher in people with diabetes and with previous myocardial infarction. Smoking was associated with increased diastolic BP and decreased systolic BP. Alcohol intake as well as BP measurement on left vs. right arm had no association with BP reading. The MMM17 was the largest BP screening campaign ever held in the country. A considerable percentage of detected hypertensives were not on treatment with a significant proportion of uncontrolled hypertension among those on treatment. These results suggest that opportunistic screening can identify significant numbers with raised BP

Medication errors in the Middle East countries: a systematic review of the literature

Background: Medication errors are a significant global concern and can cause serious medical consequences for patients. Little is known about medication errors in Middle Eastern countries. The objectives of this systematic review were to review studies of the incidence and types of medication errors in Middle Eastern countries and to identify the main contributory factors involved. Methods: A systematic review of the literature related to medication errors in Middle Eastern countries was conducted in October 2011 using the following databases: Embase, Medline, Pubmed, the British Nursing Index and the Cumulative Index to Nursing & Allied Health Literature. The search strategy included all ages and languages. Inclusion criteria were that the studies assessed or discussed the incidence of medication errors and contributory factors to medication errors during the medication treatment process in adults or in children. Results: Forty-five studies from 10 of the 15 Middle Eastern countries met the inclusion criteria. Nine (20%) studies focused on medication errors in paediatric patients. Twenty-one focused on prescribing errors, 11 measured administration errors, 12 were interventional studies and one assessed transcribing errors. Dispensing and documentation errors were inadequately evaluated. Error rates varied from 7.1% to 90.5% for prescribing and from 9.4% to 80% for administration. The most common types of prescribing errors reported were incorrect dose (with an incidence rate from 0.15% to 34.8% of prescriptions), wrong frequency and wrong strength. Computerised physician rder entry and clinical pharmacist input were the main interventions evaluated. Poor knowledge of medicines was identified as a contributory factor for errors by both doctors (prescribers) and nurses (when administering drugs). Most studies did not assess the clinical severity of the medication errors. Conclusion: Studies related to medication errors in the Middle Eastern countries were relatively few in number and of poor quality. Educational programmes on drug therapy for doctors and nurses are urgently needed

Real-Space Mesh Techniques in Density Functional Theory

This review discusses progress in efficient solvers which have as their foundation a representation in real space, either through finite-difference or finite-element formulations. The relationship of real-space approaches to linear-scaling electrostatics and electronic structure methods is first discussed. Then the basic aspects of real-space representations are presented. Multigrid techniques for solving the discretized problems are covered; these numerical schemes allow for highly efficient solution of the grid-based equations. Applications to problems in electrostatics are discussed, in particular numerical solutions of Poisson and Poisson-Boltzmann equations. Next, methods for solving self-consistent eigenvalue problems in real space are presented; these techniques have been extensively applied to solutions of the Hartree-Fock and Kohn-Sham equations of electronic structure, and to eigenvalue problems arising in semiconductor and polymer physics. Finally, real-space methods have found recent application in computations of optical response and excited states in time-dependent density functional theory, and these computational developments are summarized. Multiscale solvers are competitive with the most efficient available plane-wave techniques in terms of the number of self-consistency steps required to reach the ground state, and they require less work in each self-consistency update on a uniform grid. Besides excellent efficiencies, the decided advantages of the real-space multiscale approach are 1) the near-locality of each function update, 2) the ability to handle global eigenfunction constraints and potential updates on coarse levels, and 3) the ability to incorporate adaptive local mesh refinements without loss of optimal multigrid efficiencies.Comment: 70 pages, 11 figures. To be published in Reviews of Modern Physic