116 research outputs found
Quantum corrections to the Pekar asymptotics of a strongly coupled polaron
We consider the Fr\"ohlich polaron model in the strong coupling limit. It is
well known that to leading order the ground state energy is given by the
(classical) Pekar energy. In this work, we establish the subleading correction,
describing quantum fluctuation about the classical limit. Our proof applies to
a model of a confined polaron, where both the electron and the polarization
field are restricted to a set of finite volume, with linear size determined by
the natural length scale of the Pekar problem.Comment: LaTeX, 40 pages; final version, to appear in Commun. Pure. Appl. Mat
PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study
Different Domains of the RNA Polymerase of Infectious Bursal Disease Virus Contribute to Virulence
BACKGROUND: Infectious bursal disease virus (IBDV) is a pathogen of worldwide significance to the poultry industry. IBDV has a bi-segmented double-stranded RNA genome. Segments A and B encode the capsid, ribonucleoprotein and non-structural proteins, or the virus polymerase (RdRp), respectively. Since the late eighties, very virulent (vv) IBDV strains have emerged in Europe inducing up to 60% mortality. Although some progress has been made in understanding the molecular biology of IBDV, the molecular basis for the pathogenicity of vvIBDV is still not fully understood. METHODOLOGY, PRINCIPAL FINDINGS: Strain 88180 belongs to a lineage of pathogenic IBDV phylogenetically related to vvIBDV. By reverse genetics, we rescued a molecular clone (mc88180), as pathogenic as its parent strain. To study the molecular basis for 88180 pathogenicity, we constructed and characterized in vivo reassortant or mosaic recombinant viruses derived from the 88180 and the attenuated Cu-1 IBDV strains. The reassortant virus rescued from segments A of 88180 (A88) and B of Cu-1 (BCU1) was milder than mc88180 showing that segment B is involved in 88180 pathogenicity. Next, the exchange of different regions of BCU1 with their counterparts in B88 in association with A88 did not fully restore a virulence equivalent to mc88180. This demonstrated that several regions if not the whole B88 are essential for the in vivo pathogenicity of 88180. CONCLUSION, SIGNIFICANCE: The present results show that different domains of the RdRp, are essential for the in vivo pathogenicity of IBDV, independently of the replication efficiency of the mosaic viruses
Use and efficacy of bone morphogenetic proteins in fracture healing
Signal transduction in aging related disease
Die Darstellung mittelalterlicher Geschichte in der deutschen Kunst des ausgehenden 18. Jahrhunderts
Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue
Ein Bild sagt mehr als tausend Worte: Die Macht der Bildkommunikation [A picture is worth a thousand words: The power of visual communication]
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