Signal transduction in aging related disease

A Daluiski

A Valentin-Opran

AL Jones

AP White

AT Dudley

B Rittenberg

B Shen

Cornelis F. M. Sier

D Chen

D Mines

D Onichtchouk

David J. J. de Gorter

DB Dean

DC Wan

DE Komatsu

DG Winkler

DJ Gorter de

DM Kingsley

E Kessler

E Pardali

E Tsialogiannis

E Tsiridis

E Valera

EE Storm

G Luo

G Mundy

G Sapkota

GA Helm

GB Bishop

GE Friedlaender

GM Calori

H Chen

H Cheng

I López-Coviella

Inger B. Schipper

J Heinke

J Ristiniemi

J Tazaki

JA Jane Jr

JB Sipe

JD Boerckel

JJ Song

JL Dube

JM Wozney

JZ Li

K Bobacz

K Miyazono

K Song

K Tachi

KR Garrison

L Wilkinson

LC Fuentealba

LW Gamer

M Pecina

M Scharpfenecker

MK Majumdar

MR Urist

N Feiner

NK Kanakaris

NS Cunningham

O Ishibashi

P Varady

P Yilgor

PC Bessa

PV Giannoudis

Q Kang

R Bilic

R Dimitriou

RG Geesink

RJ DiLeone

RJ Dumont

S Einem von

S Govender

S Maeda

S Pauly

S Vainio

S Vukicevic

S Vukicević

SC Fu

Suzanne N. Lissenberg-Thunnissen

T Alliston

T Barr

T Meling

T Tosounidis

TJ Cho

V Alt

V Rosen

W Zhu

WA Grasser

Y Katayama

YY Yu

Z Dahabreh

English

PubMed

Crossref

International Orthopaedics

Use and efficacy of bone morphogenetic proteins in fracture healing

Lissenberg-Thunnissen, S.N.

Gorter, D.J.J. de

Sier, C.F.M.

Schipper, I.B.

Leiden University Scholary Publications

PURPOSE This review evaluates the application of bone morphogenetic proteins (BMPs) in delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an overview of the role of the different BMPs, their antagonists and their current applications, special attention is focused on new scientific developments improving the effects of BMP-based therapy for bone repair. METHODS Publication searches in PubMed and Embase revealed 850 relevant articles on the criteria 'BMP' AND 'bone repair' (as of May 2011). The abstracts were carefully reviewed and papers were selected according to the content. RESULTS The resulting publications showed that BMP-2 and BMP-7 are clearly the most extensively evaluated BMPs, in general with positive results on bone healing, comparable to the use of unspecific preparations such as autologous bone grafts or platelet-rich plasma. CONCLUSIONS Although the efficacy of BMPs as stimulators of bone repair has been demonstrated in model systems and clinical studies, the use of BMPs to enhance fracture healing in the clinical setting is still controversial. Issues such as when, where and how much of which BMP is the most effective and profitable to use still have to be elucidated. But optimisation of the BMP products used in combination with cheaper production methods will inevitably stimulate the clinical use of BMPs for bone fracture healing in the near future.Surger

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Use and efficacy of bone morphogenetic proteins in fracture healing

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