Emergent Form from Structural Optimisation of the Voronoi Polyhedra Structure

In the course of the exploration of computational means in the architectural design process, in order to investigate more complex, adaptive geometries, the Voronoi diagram has recently gained some attention, being a three-dimensional space-filling structure which is modular but not repetitive. The project looks at the Voronoi diagram as a load-bearing structure, and whether it can be useful for structural optimisation. Hereby the edges of the Voronoi polyhedra are regarded as structural members of a statical system, which then is assessed by structural analysis software. Results seem to indicate that the Voronoi approach produces a very specific structural as well as spatial type of order. Through the dislocation of the Voronoi cells, the statical structure becomes more complex through emergent topology changes, and the initially simple spatial system becomes much more complex through emerging adjacencies and interconnections between spaces. The characteristics of the emerging form, however, lie rather in the complexity how shifted spaces and parts are fitted together, than in a radical overall emergent geometry. Spatially as well as a structurally, the form moves from a simple modular repetitive system towards a more complex adaptive one, with interconnected parts which cannot stand alone but rather form an organic whole

Governance of the world food system and crisis prevention

The present study offers a framework, rooted in Disaster Studies. The next few sections will first discuss the analytical tool box, which we have largely drawn from Disaster Studies. Thereafter the food regime will be looked into in the quantitative (food security, Section 3.1) and qualitative sense (food safety, Section 3.2), and the actors and rules and regulations for international food aid discussed. It will become clear that the private sector has a key role to play in both categories. Chapter 4 calls attention to the increasing complexities and uncertainties in the global food system that complicate food governance. To get anything done at all, a simplification seems necessary, such as declaring a food problem a safety issue

Tactics for Designing Probes to Explore Parents' Differing Perspectives on Family Technology Use

Experiences of technology use in everyday family life can be complex. In particular, tensions can arise when parents have differing perspectives on their family's technology use. This paper describes design tactics we used to create a probe collection that successfully supported explorations of these differing perspectives, and to uncover the tensions involved whilst remaining sensitive to any existing conflict. The tactics created opportunities for conversation between parents and to shift their individual perspectives. These tactics helped to raise the awareness sets of parents' had of each other's perspectives on their family's technology use. Unexpected insights emerged that even surprised our participants, when they were asked to invert their point of view to imagine how their technologies might experience domestic life. Furthermore, deeper insights emerged when participants' responses to individual probes were viewed together, as a collection

The behavioural assessment of the dysexecutive syndrome as a tool to assess executive functions in schizophrenia

Recent research into the cognitive dysfunctions in schizophrenia has focused on executive deficits. This study investigates performance of patients with schizophrenia on the recently developed Behavourial Assessment of the Dysexecutive Syndrome (BADS). Matched groups of 24 patients with schizophrenia and 17 healthy volunteers were administered the BADS, the Modified Card Sorting Test (MCST), the Tower of London (TOL), a test of general intelligence, and measures of daily functioning. Performance of the schizophrenic group was significantly below that of the control group on the BADS and the MCST, but not on the TOL. The BADS correlated weakly with the MCST. Both tests showed a modest correlation with daily functioning. The BADS appears to offer a useful contribution to the assessment of executive deficits in schizophrenia

Enabling scalable clinical interpretation of ML-based phenotypes using real world data

The availability of large and deep electronic healthcare records (EHR) datasets has the potential to enable a better understanding of real-world patient journeys, and to identify novel subgroups of patients. ML-based aggregation of EHR data is mostly tool-driven, i.e., building on available or newly developed methods. However, these methods, their input requirements, and, importantly, resulting output are frequently difficult to interpret, especially without in-depth data science or statistical training. This endangers the final step of analysis where an actionable and clinically meaningful interpretation is needed.This study investigates approaches to perform patient stratification analysis at scale using large EHR datasets and multiple clustering methods for clinical research. We have developed several tools to facilitate the clinical evaluation and interpretation of unsupervised patient stratification results, namely pattern screening, meta clustering, surrogate modeling, and curation. These tools can be used at different stages within the analysis. As compared to a standard analysis approach, we demonstrate the ability to condense results and optimize analysis time. In the case of meta clustering, we demonstrate that the number of patient clusters can be reduced from 72 to 3 in one example. In another stratification result, by using surrogate models, we could quickly identify that heart failure patients were stratified if blood sodium measurements were available. As this is a routine measurement performed for all patients with heart failure, this indicated a data bias. By using further cohort and feature curation, these patients and other irrelevant features could be removed to increase the clinical meaningfulness. These examples show the effectiveness of the proposed methods and we hope to encourage further research in this field.Comment: 27 pages, 14 figure

Isometric Embedding of BPS Branes in Flat Spaces with Two Times

We show how non-near horizon p-brane theories can be obtained from two embedding constraints in a flat higher dimensional space with 2 time directions. In particular this includes the construction of D3 branes from a flat 12-dimensional action, and M2 and M5 branes from 13 dimensions. The worldvolume actions are determined by constant forms in the higher dimension, reduced to the usual expressions by Lagrange multipliers. The formulation affords insight in the global aspects of the spacetime geometries and makes contact with recent work on two-time physics.Comment: 29 pages, 10 figures, Latex using epsf.sty and here.sty; v2: reference added and some small correction

Seeking creativity: A case study on information problem solving in professional music

This study explored the information seeking behavior of a professional jazz musician during creative work. It aimed at revealing information seeking activities necessary to execute present-day musical projects. A single case was studied in depth. First, a narrative interview was conducted to reveal project phases and corresponding information seeking behavior. Second, hereupon a semi-structured interview was taken to identify information seeking activities per phase. Results indicate that the musician deliberately searched for musical information especially in the first project phases. The internet was used as main source. Both data and goal driven strategies were applied, of which the latter were relatively scarce. This means that in this case the musician sporadically searched information based on a contemplated search plan. Future research should aim at generalizing findings of this case. It should further validate the underlying analytical framework that proved to be useful for describing and categorizing musical information seeking behavior

Mental status and health-related quality of life in an elderly population 15 years after limited cerebral ischaemia

BACKGROUND: Stroke has a major impact on survivors. Our study was designed to describe the mental status and health-related quality of life (HRQoL) in long-term survivors of TIA or minor ischaemic stroke (MIS) and evaluate associations of mental and physical factors with HR-QoL. METHODS: A random sample of the 10-year survivors of the Dutch TI