Straight versus S-shaped sternotomy: a histologic study in the sheep model

INTRODUCTION: Straight sternotomy is the most common access for open heart surgery. Techniques have been proposed for maximizing sternal stability in high-risk patients. This trend implies a growing need for newer surgical techniques. The aim of this experimental study in the sheep model is to evaluate median vs. S shaped sternotomy the feasibility of using a special device to accelerate the sternal instability and bone healing. MATERIALS AND METHODS: We enrolled 31 sheep, weighing 18–30 kg. For all animals a midline skin incision was made. In group I (n = 16 animals), straight median sternotomy and in group II (n = 15 animals), S-shaped incision was marked on the periosteum of the sternum by new created device for standard S-shaped sternotomy. Sternum biopsies were performed on second surgery month for all survived animals from the sternum and the surrounding soft tissue. RESULTS: No early superficial wound complications were observed. Overall mortality in the initial approach group was 19.3% (6 sheep). In group I; 3 sheep had died on first surgery day, the reason may be hemorrhage and in group II; 3 sheep developed intractable VF during surgery procedure or immediately afterwards so died. There were statistically significant differences in the scores of bone healing between group 1 and group 2 (4.2 vs.7.3, ANOVA, p < 0.001). DISCUSSION: Our work is based on the use of a standard S-shaped sternotomy procedure on sheep sternum. In our experience with the sternal healing in the sheep model, the process of new bone formation was accelerated with S- shaped cut than straight sternotomy procedure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13019-014-0173-x) contains supplementary material, which is available to authorized users

Choroid Plexus Papillomas in two Siblings: Case Report [İki Kardeşte Görülen Koroid Pleksus Papillomu: Olgu Sunumu]

Choroid plexus papilloma (CPP) is a rare, benign epithelial brain tumor of the nervous system seen particularly in infants. Familial cases are extremely uncommon. Some other form of malignant tumors was noted in the relatives of patients with CPPs, and some genetic defects regarding this coincidence were reported in the literature. These neoplasms are occasionally bilateral and hydrocephalus is an associated sign in most of the cases. We report three lateral ventricle CPPs in two siblings, at the age of 7 month and 2 years respectively. All tumors were resected with parietotemporal craniotomy and a superior temporal sulcus approach to the lateral ventricle. To avoid a concomitant need of ventriculoperitoneal shunt insertion, external ventricular drainage was inserted for a week in the postoperative period relieving symptoms of hydrocephalus. Search for a hereditary defect in the p53 gene of the second infant (7 months old) revealed no mutation. Postoperative courses were uneventful and the patients were followed for three years without any recurrence. Bilateral CPPS are rare and unusual in two siblings. A genetic predisposition such as the p53 mutation should be investigated in bilateral CPPs in particular

Karl popper's architectural legacy: An intertextual reading of collage city (1)

Colin Rowe and Fred Koetter's book Collage City has been one of the most inspiring works in the field of architecture with its elaborate and stimulating critique of Modernist and Post-war architecture and city planning. Published first as an article in 1975 and later as a book in 1978, Collage City has been one of the cornerstones of postmodern architectural and urban theory since. Philosopher Karl Popper's ideas on historicism, utopia, tradition, liberal society, etc. had a great influence in shaping the urban architectural theory and design model of Colin Rowe and his pedagogical approach. Karl Popper's impact is very obvious in the book and at its preceding Rowe's Cornell urban design studio. However, little attention has been paid to his legacy on Collage City. This paper traces Karl Popper's legacy on Rowe's urban design theories and methods through an in-depth comparative reading of Collage City and Popper's seminal publications. I argue that a thorough understanding of the context and the content of the collage city argument, and therefore this specific episode in architectural thinking and its contemporary remnants, can only be grasped truly through this intertextual reading. Hence, the intertextual reading in this paper reveals the social, political, and philosophical basis of the collage city argument, which has been approached mainly as a formalist premise so far. In conclusion, the paper aims to reveal the difficult, ambiguous, even blurred, but also productive relationship between the ideas of Colin Rowe and Karl Popper, between architecture and philosophy.OLD Public Buidin

Reclaiming Context: Architectural Theory, Pedagogy and Practice since 1950

Context is a crucial concept in architecture, despite the frequent ambiguity around its use. It is present in many architectural thoughts and discussions, while a critical discursive reflection is absent from contemporary architectural theory and practice. Situated within this schizophrenic condition in which the notion is both absent and present, this study aims at creating a historical and theoretical basis for a contemporary discussion on context. Discussions on context or alike notions had always existed in the field of architecture but the debate intensified and developed as a multi-layered body of knowledge in the 1950s, when various architects, theorists and teachers cultivated several perspectives on context as to address some of the ill effects of modern architectural orthodoxy and the destructive effects of post- war reconstructions. Despite being a topic of layered and productive debate in the post-war years, context lost popularity in the critical architectural discourse of the 1980s when it was absorbed by postmodern historicism and eclecticism, co-opted by traditionalists and conservationists, and consequentially attacked by the neo-avant-gardes for its blinkered understanding. This research presents a critical archaeology of the context debate, aiming to reclaim the notion by uncovering its erased, forgotten and abandoned dimensions. To do so, it challenges the governing paradigm of 1980s postmodern architecture by making inquiries into the history and genealogy of its particular trajectories with a criticism from within. Taking 1980 as a starting point, coinciding with the First Venice Architecture Biennale, the research traces the debate on context back to the 1950s through an in-depth study and interpretation of the ideas and works of Aldo Rossi, Robert Venturi and Denise Scott Brown and Colin Rowe. This reverse chronology reveals that in the works of these protagonists the understanding of context has shifted from “place to memory”, from “spatial to iconographic” and from “layers to object”, where the former categories still hold the capacity to recover the notion as a critical concept that is intrinsic to the architectural design process. In brief, by drawing upon the vast resources available in different media, such as exhibitions, archival materials, student projects, publications, buildings, etc., the study constructs an outline of “the context thinking” as it was articulated in architectural culture in the period between 1950s and 1980s.OLD Public Buidin

The Context Debate: An Archaeology

Context is a crucial concept in architecture in spite of the frequent ambiguity around its use. Although the consideration of context is intrinsic to the process of architectural design, in contemporary theory, little attention is paid to it. By way of contrast, in the 1950s, various architects, theorists, and teachers cultivated several perspectives on context as a way of addressing some of the ill effects of modern architectural orthodoxy. Although a topic of layered and productive debate in the post-war years, context fell into disrepute in the critical architectural discourse of the 1980s. This paper provides an archaeology of the “context debate” in the hope that it may be possible to reveal its forgotten dimensions and flexibility.OLD Public Buidin

Effect of caffeic acid phenethyl ester on corneal neovascularization in rats

WOS: 000174375200009PubMed ID: 11852431Purpose. Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal neovascularization (CNV) induced by silver nitrate cauterization in rats. Methods. Following silver nitrate cauterization on both eyes, male rats were randomly assigned to the study and control groups, each consisting of ten rats. The inhibitory effects of the test drugs against a placebo (isotonic saline) on CNV were tested and compared to each other using a previously described method in which extent of neovascularization and burn stimulus intensity were scored by a masked examiner. Briefly, burn stimulus intensity was scored from 0 to + 3 according to the height of blister from corneal surface, and extent of neovascularization was recorded from 0 to + 6 according to the distance from limbus to the end point of CNV toward the central corneal burn. Results. The mean burn stimulus score were not different among the groups (P=0.807). Percent inhibition of CNV compared to the placebo control and its significance were 31.5%, P=0.011 for indomethacin; 56%, P0.05) dexamethasone in reducing CNV. Conclusion. Topically applied CAPE was demonstrated to have an inhibitory effect, comparable to that of topical dexamethasone, on CNV in this rat model. Antiinflammatory and antioxidant properties of CAPE may contribute to its suppression on CNV