588 research outputs found
The use of a nonradioactive probe in RFLP analysis of Neurospora crassa DNA
Our laboratory is investigating the use of nonradioactive alternatives for the synthesis of DNA probes used in hybridization experiments
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Design of a pixel cell optimized for a data push architecture readout
A pixel cell has been designed which has been optimized for a data push architecture readout. It retains the features of preceding designs which allow time stamping, analog signal processing, XY address recording, ghost elimination and sparse data transmission. It eliminates a number of problems inherent in previous designs by use of sampled data techniques, destructive readout sampled data techniques, and current mode output drivers. This document examines the motivation for this new pixel and covers the theory of operation of the various blocks. A discussion of the tradeoffs affecting speed, power, device size, and radiation stability is included as well
Production in Two-Photon Processes at TRISTAN
We have carried out an inclusive measurement of production
in two-photon processes at TRISTAN. The mean was 58 GeV and the
integrated luminosity was 199 pb. High-statistics samples were
obtained under such conditions as no-, anti-electron, and remnant-jet tags. The
remnant-jet tag, in particular, allowed us, for the first time, to measure the
cross sections separately for the resolved-photon and direct processes.Comment: 20 pages, Latex format, 4 figures and KEK-mark included. Table 1
revised. To be published in Phys. Lett.
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Measurements of elastic and quasi-elastic scatterings of pp and -pp from ~ 20 to 40 GeV/c
We propose a systematic study of elastic and quasi-elastic scatterings of pp and {bar p}p in the forward region (|t{vert_bar} {approx}< 1.5 GeV{sup 2}) from {approx} 20 to 40 GeV/c by using the single-arm spectrometer of NAL Exp. 7 without any essential change. The physics interests in this energy region warrant a precise comparison between pp and {bar p}p as a function of s(t) for fixed t(s). Therefore it is essential to use the same experimental apparatus and analysis procedures in order to minimize possible systematic errors. The possible future experiments at Serpukhov will not be able to produce sufficient flux in the secondary {bar p} beams to answer the physics questions raised in this proposal
Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses
Efficient generation of antibodies by B cells is one of the prerequisites of protective immunity. B cell activation by cognate antigens via B cell receptors (BCRs), or pathogen-associated molecules through pattern-recognition receptors, such as Toll-like receptors (TLRs), leads to transcriptional and metabolic changes that ultimately transform B cells into antibody-producing plasma cells or memory cells. BCR signaling and a number of steps downstream of it rely on coordinated action of cellular membranes and the actin cytoskeleton, tightly controlled by concerted action of multiple regulatory proteins, some of them exclusive to B cells. Here, we dissect the role of Missing-In-Metastasis (MIM), or Metastasis suppressor 1 (MTSS1), a cancer-associated membrane and actin cytoskeleton regulating protein, in B cell-mediated immunity by taking advantage of MIM knockout mouse strain. We show undisturbed B cell development and largely normal composition of B cell compartments in the periphery. Interestingly, we found that MIM-/- B cells are defected in BCR signaling in response to surface-bound antigens but, on the other hand, show increased metabolic activity after stimulation with LPS or CpG. In vivo, MIM knockout animals exhibit impaired IgM antibody responses to immunization with T cell-independent antigen. This study provides the first comprehensive characterization of MIM in B cells, demonstrates its regulatory role for B cell-mediated immunity, as well as proposes new functions for MIM in tuning receptor signaling and cellular metabolism, processes, which may also contribute to the poorly understood functions of MIM in cancer
Photoproduction of phi(1020) mesons on the proton at large momentum transfer
The cross section for meson photoproduction on the proton has been
measured for the first time up to a four-momentum transfer -t = 4 GeV^2, using
the CLAS detector at the Thomas Jefferson National Accelerator Facility. At low
four-momentum transfer, the differential cross section is well described by
Pomeron exchange. At large four-momentum transfer, above -t = 1.8 GeV^2, the
data support a model where the Pomeron is resolved into its simplest component,
two gluons, which may couple to any quark in the proton and in the .Comment: 5 pages; 7 figure
Dependence of Quadrupole Strength in the Transition
Models of baryon structure predict a small quadrupole deformation of the
nucleon due to residual tensor forces between quarks or distortions from the
pion cloud. Sensitivity to quark versus pion degrees of freedom occurs through
the dependence of the magnetic (), electric (), and
scalar () multipoles in the
transition. We report new experimental values for the ratios
and over the range = 0.4-1.8 GeV, extracted from
precision data using a truncated multipole expansion.
Results are best described by recent unitary models in which the pion cloud
plays a dominant role.Comment: 5 pages, 5 figures, 1 table. To be published in Phys. Rev. Lett.
(References, figures and table updated, minor changes.
Measurement of the Polarized Structure Function for in the Resonance Region
The polarized longitudinal-transverse structure function
has been measured using the reaction in the
resonance region at and 0.65 GeV. No previous
data exist for this reaction channel. The kinematically
complete experiment was performed at Jefferson Lab with the CEBAF Large
Acceptance Spectrometer (CLAS) using longitudinally polarized electrons at an
energy of 1.515 GeV. A partial wave analysis of the data shows generally better
agreement with recent phenomenological models of pion electroproduction
compared to the previously measured channel. A fit to both
and channels using a unitary isobar model suggests the unitarized
Born terms provide a consistent description of the non-resonant background. The
-channel pion pole term is important in the channel through a
rescattering correction, which could be model-dependent.Comment: 6 pages, LaTex, 5 eps figures: Submitted to PRC/Brief Reports v2:
Updated referenc
Deeply virtual and exclusive electroproduction of omega mesons
The exclusive omega electroproduction off the proton was studied in a large
kinematical domain above the nucleon resonance region and for the highest
possible photon virtuality (Q2) with the 5.75 GeV beam at CEBAF and the CLAS
spectrometer. Cross sections were measured up to large values of the
four-momentum transfer (-t < 2.7 GeV2) to the proton. The contributions of the
interference terms sigma_TT and sigma_TL to the cross sections, as well as an
analysis of the omega spin density matrix, indicate that helicity is not
conserved in this process. The t-channel pi0 exchange, or more generally the
exchange of the associated Regge trajectory, seems to dominate the reaction
gamma* p -> omega p, even for Q2 as large as 5 GeV2. Contributions of handbag
diagrams, related to Generalized Parton Distributions in the nucleon, are
therefore difficult to extract for this process. Remarkably, the high-t
behaviour of the cross sections is nearly Q2-independent, which may be
interpreted as a coupling of the photon to a point-like object in this
kinematical limit.Comment: 15 pages,19 figure
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