453 research outputs found
Correlation and response in a driven dissipative model
We consider a simple dissipative system with spatial structure in contact
with a heat bath. The system always exhibits correlations except in the cases
of zero and maximal dissipation. We explicitly calculate the correlation
function and the nonlocal response function of the system and show that they
have the same spatial dependence. Finally, we examine heat transfer in the
model, which agrees qualitatively with simulations of vibrated granular gases
First record of the invasive species Parasaissetia nigra in Greece
Στην παρούσα εργασία γίνεται η πρώτη καταγραφή του είδους Parasaissetia nigra (Nietner) (Hemiptera: Coccidae) επί της ροδιάς στην Ελλάδα. Η παρουσία του είδους αυτού διαπιστώθηκε σε καλλωπιστική ροδιά, τον Ιούνιο του 2014, εντός της Πανεπιστημιούπολης του Γεωπονικού Πανεπιστημίου Αθηνών. Δίδονται πληροφορίες σχετικά με τα μορφολογικά και βιολογικά χαρακτηριστικά, όπως και για την εξάπλωση του εντόμου.In June 2014, the nigra scale Parasaissetia nigra (Nietner) (Hemiptera: Coccidae) was recorded for the first time in Greece on pomegranate, Punica granatum. Its occurrence was observed in an ornamental pomegranate tree in the campus of the Agricultural University of Athens. Information on its morphology, biology and distribution is presented
Testing systems of identical components
We consider the problem of testing sequentially the components of a multi-component reliability system in order to figure out the state of the system via costly tests. In particular, systems with identical components are considered. The notion of lexicographically large binary decision trees is introduced and a heuristic algorithm based on that notion is proposed. The performance of the heuristic algorithm is demonstrated by computational results, for various classes of functions. In particular, in all 200 random cases where the underlying function is a threshold function, the proposed heuristic produces optimal solutions
Generalized inverse mean curvature flows in spacetime
Motivated by the conjectured Penrose inequality and by the work of Hawking,
Geroch, Huisken and Ilmanen in the null and the Riemannian case, we examine
necessary conditions on flows of two-surfaces in spacetime under which the
Hawking quasilocal mass is monotone. We focus on a subclass of such flows which
we call uniformly expanding, which can be considered for null as well as for
spacelike directions. In the null case, local existence of the flow is
guaranteed. In the spacelike case, the uniformly expanding condition leaves a
1-parameter freedom, but for the whole family, the embedding functions satisfy
a forward-backward parabolic system for which local existence does not hold in
general. Nevertheless, we have obtained a generalization of the weak
(distributional) formulation of this class of flows, generalizing the
corresponding step of Huisken and Ilmanen's proof of the Riemannian Penrose
inequality.Comment: 21 pages, 1 figur
Evaluation of Methodologies for Microrna Biomarker Detection by Next Generation Sequencing
In recent years, microRNAs (miRNAs) in tissues and biofluids have emerged as a new class of promising biomarkers for numerous diseases. Blood-based biomarkers are particularly desirable since serum or plasma is easily accessible and can be sampled repeatedly. To comprehensively explore the biomarker potential of miRNAs, sensitive, accurate and cost-efficient miRNA profiling techniques are required. Next generation sequencing (NGS) is emerging as the preferred method for miRNA profiling; offering high sensitivity, single-nucleotide resolution and the possibility to profile a considerable number of samples in parallel. Despite the excitement about miRNA biomarkers, challenges associated with insufficient characterization of the sequencing library preparation efficacy, precision and method-related quantification bias have not been addressed in detail and are generally underappreciated in the wider research community.
Here, we have tested in parallel four commercially available small RNA sequencing kits against a cohort of samples comprised of human plasma, human serum, murine brain tissue and a reference library containing ~ 950 synthetic miRNAs. We discuss the advantages and limits of these methodologies for massive parallel microRNAs profiling. This work can serve as guideline for choosing an adequate library preparation method, based on sensitivity, specificity and accuracy of miRNA quantification, workflow convenience and potential for automation
The Role of Friction in Compaction and Segregation of Granular Materials
We investigate the role of friction in compaction and segregation of granular
materials by combining Edwards' thermodynamic hypothesis with a simple
mechanical model and mean-field based geometrical calculations. Systems of
single species with large friction coefficients are found to compact less.
Binary mixtures of grains differing in frictional properties are found to
segregate at high compactivities, in contrary to granular mixtures differing in
size, which segregate at low compactivities. A phase diagram for segregation
vs. friction coefficients of the two species is generated. Finally, the
characteristics of segregation are related directly to the volume fraction
without the explicit use of the yet unclear notion of compactivity.Comment: 9 pages, 6 figures, submitted to Phys. Rev.
Apparent wave function collapse caused by scattering
Some experimental implications of the recent progress on wave function
collapse are calculated. Exact results are derived for the center-of-mass wave
function collapse caused by random scatterings and applied to a range of
specific examples. The results show that recently proposed experiments to
measure the GRW effect are likely to fail, since the effect of naturally
occurring scatterings is of the same form as the GRW effect but generally much
stronger. The same goes for attempts to measure the collapse caused by quantum
gravity as suggested by Hawking and others. The results also indicate that
macroscopic systems tend to be found in states with (Delta-x)(Delta-p) =
hbar/sqrt(2), but microscopic systems in highly tiltedly squeezed states with
(Delta-x)(Delta-p) >> hbar.Comment: Final published version. 20 pages, Plain TeX, no figures. Online at
http://astro.berkeley.edu/~max/collapse.html (faster from the US), from
http://www.mpa-garching.mpg.de/~max/collapse.html (faster from Europe) or
from [email protected]
Human plasma and serum extracellular small RNA reference profiles and their clinical utility
Circulating extracellular RNAs (exRNAs) have the potential to serve as biomarkers for a wide range of medical conditions. However, limitations in existing exRNA isolation methods and a lack of knowledge on parameters affecting exRNA variability in human samples may hinder their successful discovery and clinical implementation. Using combinations of denaturants, reducing agents, proteolysis, and revised organic extraction, we developed an automated, high-throughput approach for recovery of exRNAs and exDNA from the same biofluid sample. We applied this method to characterize exRNAs from 312 plasma and serum samples collected from 13 healthy volunteers at 12 time points over a 2-month period. Small RNA cDNA library sequencing identified nearly twofold increased epithelial-, muscle-, and neuroendocrine-cell–specific miRNAs in females, while fasting and hormonal cycle showed little effect. External standardization helped to detect quantitative differences in erythrocyte and platelet-specific miRNA contributions and in miRNA concentrations between biofluids. It also helped to identify a study participant with a unique exRNA phenotype featuring a miRNA signature of up to 20-fold elevated endocrine-cell–specific miRNAs and twofold elevated total miRNA concentrations stable for over 1 year. Collectively, these results demonstrate an efficient and quantitative method to discern exRNA phenotypes and suggest that plasma and serum RNA profiles are stable over months and can be routinely monitored in long-term clinical studies
Does the universe in fact contain almost no information?
At first sight, an accurate description of the state of the universe appears
to require a mind-bogglingly large and perhaps even infinite amount of
information, even if we restrict our attention to a small subsystem such as a
rabbit. In this paper, it is suggested that most of this information is merely
apparent, as seen from our subjective viewpoints, and that the algorithmic
information content of the universe as a whole is close to zero. It is argued
that if the Schr\"odinger equation is universally valid, then decoherence
together with the standard chaotic behavior of certain non-linear systems will
make the universe appear extremely complex to any self-aware subsets that
happen to inhabit it now, even if it was in a quite simple state shortly after
the big bang. For instance, gravitational instability would amplify the
microscopic primordial density fluctuations that are required by the Heisenberg
uncertainty principle into quite macroscopic inhomogeneities, forcing the
current wavefunction of the universe to contain such Byzantine superpositions
as our planet being in many macroscopically different places at once. Since
decoherence bars us from experiencing more than one macroscopic reality, we
would see seemingly complex constellations of stars etc, even if the initial
wavefunction of the universe was perfectly homogeneous and isotropic.Comment: 17 pages, LATeX, no figures. Online with refs at
http://astro.berkeley.edu/~max/nihilo.html (faster from the US), from
http://www.mpa-garching.mpg.de/~max/nihilo.html (faster from Europe) or from
[email protected]
How does flow in a pipe become turbulent?
The transition to turbulence in pipe flow does not follow the scenario
familiar from Rayleigh-Benard or Taylor-Couette flow since the laminar profile
is stable against infinitesimal perturbations for all Reynolds numbers.
Moreover, even when the flow speed is high enough and the perturbation
sufficiently strong such that turbulent flow is established, it can return to
the laminar state without any indication of the imminent decay. In this
parameter range, the lifetimes of perturbations show a sensitive dependence on
initial conditions and an exponential distribution. The turbulence seems to be
supported by three-dimensional travelling waves which appear transiently in the
flow field. The boundary between laminar and turbulent dynamics is formed by
the stable manifold of an invariant chaotic state. We will also discuss the
relation between observations in short, periodically continued domains, and the
dynamics in fully extended puffs.Comment: for the proceedings of statphys 2
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