4,457 research outputs found
Key Note: Living with droughts?
The Netherlands Center for River Research (NCR) in its first 10 years of existence has focused its activities on flooding. Climate change might cause that droughts will become as important as or even more important than floods. The dry year 2003 in Europe has shown the huge socio-economic impacts of droughts. New concepts are emerging on how to deal with droughts. This key-note addresses the issues of droughts and scarcity and makes a plea to include more drought research in NCR
Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells.
OBJECTIVE: Polyethylene glycol (PEG), an osmotic laxative, is a potent inhibitor of colon cancer in rats. In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested. We also investigated the PEG effects on crypt cells in vivo. MATERIAL AND METHODS: Fischer 344 rats (n=272) were injected with the colon carcinogen, azoxymethane. They were then randomized to a standard AIN76 diet containing one of 19 laxative agents (5% w/w in most cases): PEG 8000 and other PEG-like compounds, carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, calcium polycarbophil, karaya gum, psyllium, mannitol, sorbitol, lactulose, propylene glycol, magnesium hydroxide, sodium phosphate, bisacodyl, docusate, and paraffin oil. Aberrant crypt foci (ACF) and fecal values were measured blindly after a 30-day treatment regimen. Proliferation, apoptosis, and the removal of cells from crypts were studied in control and PEG-fed rats using various methods, including TUNEL and fluorescein dextran labeling. RESULTS: PEG 8000 reduced the number of ACF 9-fold in rats (p40-fold) a fecal marker of epitheliolysis in the gut (p<0.001). PEG normalized the percentage of fluorescein dextran labeled cells on the top of ACF (p<0.001). CONCLUSIONS: Among laxatives, only PEG afforded potent chemoprevention. PEG protection was not due to increased fecal bulking, but in all likelihood to the elimination of cells from precancerous lesions
Exploring pathways for sustainable water management in river deltas in a changing environment
Exploring adaptation pathways into an uncertain future can support decisionmaking in achieving sustainable water management in a changing environment. Our objective is to develop and test a method to identify such pathways by including dynamics from natural variability and the interaction between the water system and society. Present planning studies on long-term water management often use a few plausible futures for one or two projection years, ignoring the dynamic aspect of adaptation through the interaction between the water system and society. Our approach is to explore pathways using multiple realisations of transient scenarios with an Integrated Assessment Meta Model (IAMM). This paper presents the first application of the method using a hypothetical case study. The case study shows how to explore and evaluate adaptation pathways. With the pathways it is possible to identify opportunities, threats, timing and sequence of policy options, which can be used by policymakers to develop water management roadmaps into the future. By including the dynamics between the water system and society, the influence of uncertainties in both systems becomes clearer. The results show, among others, that climate variability rather than climate change appears to be important for taking decisions in water management
Effect analysis of transient scenarios for successful water management strategies
Recent scenario studies on water management focus on one or two projection years and the effects on the water system and functions. The future is however more complex and dynamic. Therefore, we analyse transient scenarios in order to evaluate the performance of water management strategies. Current available simulation tools are not suitable for this purpose. Therefore, we have developed and used a tool to simulate 50-100 year long time series and that is good and fast enough to simulate the effects of these scenarios and strategies on the water system and the interaction with the human system. We present the first step by means of a case study
Partial nonlinear reciprocity breaking through ultrafast dynamics in a random photonic medium
We demonstrate that ultrafast nonlinear dynamics gives rise to reciprocity
breaking in a random photonic medium. Reciprocity breaking is observed via the
suppression of coherent backscattering, a manifestation of weak localization of
light. The effect is observed in a pump-probe configuration where the pump
induces an ultrafast step-change of the refractive index during the dwell time
of the probe light in the material. The dynamical suppression of coherent
backscattering is reproduced well by a multiple scattering Monte Carlo
simulation. Ultrafast reciprocity breaking provides a distinct mechanism in
nonlinear optical media which opens up avenues for the active manipulation of
mesoscopic transport, random lasers, and photon localization.Comment: 5 pages, 4 figure
Drug Research in Inhibiting BCL6 in Ovarian Cancer
Ovarian cancer has a survival rate of 50 percent just five years after being diagnosed (Nguyen et al. 2020). Finding new ways to treat ovarian cancer is important to increase the survival of patients who have been diagnosed. BCL6 is a transcription factor that is involved with metastasis and promoting chemotherapy resistant cancer cells. Finding a way to inhibit BCL6 could help prevent the things listed above and lead to a new treatment for patients with ovarian cancer. Researching genes that BCL6 regulates may offer new insights into treatments that can be researched to see if they are effective in inhibiting BCL6, which was the focus of my research. Using bioinformatics and cell culturing I researched drugs that had the possibility of inhibiting BCL6 and tested their effectiveness against ovarian cancer cell lines
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