Correction: Internet Tool to Support Self-Assessment and Self-Swabbing of Sore Throat: Development and Feasibility Study.

[This corrects the article DOI: 10.2196/39791.]

Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients' musculoskeletal pain and enablement.

INTRODUCTION: Effective communication can help optimise healthcare interactions and patient outcomes. However, few interventions have been tested clinically, subjected to cost-effectiveness analysis or are sufficiently brief and well-described for implementation in primary care. This paper presents the protocol for determining the effectiveness and cost-effectiveness of a rigorously developed brief eLearning tool, EMPathicO, among patients with and without musculoskeletal pain. METHODS AND ANALYSIS: A cluster randomised controlled trial in general practitioner (GP) surgeries in England and Wales serving patients from diverse geographic, socioeconomic and ethnic backgrounds. GP surgeries are randomised (1:1) to receive EMPathicO e-learning immediately, or at trial end. Eligible practitioners (eg, GPs, physiotherapists and nurse practitioners) are involved in managing primary care patients with musculoskeletal pain. Patient recruitment is managed by practice staff and researchers. Target recruitment is 840 adults with and 840 without musculoskeletal pain consulting face-to-face, by telephone or video. Patients complete web-based questionnaires at preconsultation baseline, 1 week and 1, 3 and 6 months later. There are two patient-reported primary outcomes: pain intensity and patient enablement. Cost-effectiveness is considered from the National Health Service and societal perspectives. Secondary and process measures include practitioner patterns of use of EMPathicO, practitioner-reported self-efficacy and intentions, patient-reported symptom severity, quality of life, satisfaction, perceptions of practitioner empathy and optimism, treatment expectancies, anxiety, depression and continuity of care. Purposive subsamples of patients, practitioners and practice staff take part in up to two qualitative, semistructured interviews. ETHICS APPROVAL AND DISSEMINATION: Approved by the South Central Hampshire B Research Ethics Committee on 1 July 2022 and the Health Research Authority and Health and Care Research Wales on 6 July 2022 (REC reference 22/SC/0145; IRAS project ID 312208). Results will be disseminated via peer-reviewed academic publications, conference presentations and patient and practitioner outlets. If successful, EMPathicO could quickly be made available at a low cost to primary care practices across the country. TRIAL REGISTRATION NUMBER: ISRCTN18010240

No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra-runners - a randomized controlled trial

Background: The purpose of this study was to investigate the effect of short-term supplementation of amino acids before and during a 100 km ultra-marathon on variables of skeletal muscle damage and muscle soreness. We hypothesized that the supplementation of amino acids before and during an ultra-marathon would lead to a reduction in the variables of skeletal muscle damage, a decrease in muscle soreness and an improved performance. Methods: Twenty-eight experienced male ultra-runners were divided into two groups, one with amino acid supplementation and the other as a control group. The amino acid group was supplemented a total of 52.5 g of an amino acid concentrate before and during the 100 km ultra-marathon. Pre- and post-race, creatine kinase, urea and myoglobin were determined. At the same time, the athletes were asked for subjective feelings of muscle soreness. Results: Race time was not different between the groups when controlled for personal best time in a 100 km ultra-marathon. The increases in creatine kinase, urea and myoglobin were not different in both groups. Subjective feelings of skeletal muscle soreness were not different between the groups. Conclusions: We concluded that short-term supplementation of amino acids before and during a 100 km ultra-marathon had no effect on variables of skeletal muscle damage and muscle soreness

Speed during training and anthropometric measures in relation to race performance by male and female open-water ultra-endurance swimmers

The relationship of anthropometric and training characteristics with race time were investigated in 39 male and 24 female open-water ultra-endurance swimmers in a 26.4 km open-water ultra-swim, using bi- and multivariate analyses. For the men, body height, Body Mass Index, length of arm, and swimming speed during training were related to race time in the bivariate analysis. For the women, swimming speed during training was associated with performance in the bivariate analysis. In the multivariate analysis for the men, Body Mass Index and swimming speed during training were related to race time

Race performance in male mountain ultra-marathoners: anthropometry or training?

The association of anthropometric variables, training volume, and prerace experience with race time was investigated in 25 male mountain ultra-marathoners (M age = 44.5 yr., SD = 7.0; M body mass = 73.0 kg, SD = 7.8; M body height = 1.78 m, SD = 0.07; M Body Mass Index = 22.9 kg/m2, SD = 1.8) in a 7-day mountain ultra-marathon over 350 km with a total 11,000 m of altitude gained and lost. The relationship of anthropometry (body mass, body height, Body Mass Index, percent body fat, circumferences of limbs, and thicknesses of skin-folds), training, and prerace experience (years as active runner, average training volume in hours and kilometres per week, average running speed in training, and personal best time in marathon running) with total race time was investigated using bivariate correlation analysis. None of the variables of anthropometry were related to total race time. Average speed in running during training and personal best time in marathon running were associated with total race time. Speed in running during training was correlated with personal best time in marathon running. The finding that average speed in running during training and personal best marathon time were related to race performance suggests that training and especially intensity might be of increased importance in these ultra-runners compared to anthropometry

Randomized trial within a trial of yellow ‘post-it notes’ did not improve questionnaire response rates among participants in a trial of treatments for neck pain

Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post-it notes on follow-up questionnaires in the ATLAS treatment trial for neck pain reduces attrition. Method Nested trial within a trial. ATLAS participants were randomized to have their 6-month follow-up questionnaire have a 3′ yellow post-it note with a handwritten message encouraging return of questionnaire. Results 499 participants were independently randomized using simple allocation to receive the post-it notes or not. Two hundred fifteen of the 256 (84.0%) participants in the intervention group returned their questionnaire compared with 205 of the 243 (84.4%) in the control group. There was no difference in time to response. Conclusion Yellow post-it notes do not enhance questionnaire return rates for participants in a randomized trial of neck pain.</p