Scalar field description of a parametric model of dark energy

We investigate theoretical and observational aspects of a time-dependent parameterization for the dark energy equation of state (EoS) $w(z)$, which is a well behaved function of the redshift $z$ over the entire cosmological evolution, i.e., $z \in [-1,\infty)$. By using a theoretical algorithm of constructing the quintessence potential directly from the effective EoS parameter, we derive and discuss the general features of the resulting potential for this $w(z)$ function. Since the parameterization here discussed allows us to divide the parametric plane in defined regions associated to distinct classes of dark energy models, we use the most recent observations from type Ia supernovae, baryon acoustic oscillation peak and Cosmic Microwave Background shift parameter to check which class is observationally prefered. We show that the largest portion of the confidence contours lies into the region corresponding to a possible crossing of the so-called phanton divide line at some point of the cosmic evolution.Comment: 5 pages, 2 figures, LaTe

Avaliação laboratorial do tipo e teor de ligante e da granulometria na deformação permanente de misturas asfálticas

Este trabalho avaliou a influência na deformação permanente do tipo e teor de ligante asfáltico e da granulometria quanto ao método Bailey, Faixa de Agregado Dominante (FAD) e faixas granulométricas B e C por meio do ensaio uniaxial de carga repetida. Para isso utilizaram-se três ligantes asfálticos, 50/70, AMP 60/85 e o Highly Modified Asphalt (HiMA), quatro granulometrias, sendo duas Faixa B e duas C, e dois métodos de dosagem, Superpave e Marshall, totalizando 24 misturas asfálticas. Os resultados indicaram que as modificações no tipo e no teor dos ligantes asfálticos foram mais influentes na deformação permanente do que a granulometria das misturas, inclusive encontrou-se boa correlação entre a reologia dos ligantes e os Flow Numbers (FNs) obtidos. O método Bailey apresentou-se mais efetivo em conferir ganho de resistência comparado ao método FAD e a utilização da granulometria faixa B não resultou em um melhor comportamento comparado a uma granulometria faixa C

Observational constraint on generalized Chaplygin gas model

We investigate observational constraints on the generalized Chaplygin gas (GCG) model as the unification of dark matter and dark energy from the latest observational data: the Union SNe Ia data, the observational Hubble data, the SDSS baryon acoustic peak and the five-year WMAP shift parameter. It is obtained that the best fit values of the GCG model parameters with their confidence level are $A_{s}=0.73^{+0.06}_{-0.06}$ ($1\sigma$) $^{+0.09}_{-0.09}$ $(2\sigma)$, $\alpha=-0.09^{+0.15}_{-0.12}$ ($1\sigma$) $^{+0.26}_{-0.19}$ $(2\sigma)$. Furthermore in this model, we can see that the evolution of equation of state (EOS) for dark energy is similar to quiessence, and its current best-fit value is $w_{0de}=-0.96$ with the $1\sigma$ confidence level $-0.91\geq w_{0de}\geq-1.00$.Comment: 9 pages, 5 figure

Analysis of Microplastics in Food Samples

This chapter presents a compilation of the analytical techniques used to detect and analyze microplastics in food. A detailed description of microplastics found in different samples is provided as well as an estimate of the annual intake of these particles. A total of 22–37 milligrams of microplastics per year was found. The factors that can influence the presence of particles in food, especially table salt, are discussed, showing that a background presence of microplastics in the environment can explain a large amount of experimental data.Support for this work was provided by the CTQ2016-76608-R project from the Ministry of Economy, Industry and Competitiveness (Spain) and by the University of Alicante under the project UAUSTI18-06

Design and Analysis of Rhesus Cytomegalovirus IL-10 Mutants as a Model for Novel Vaccines against Human Cytomegalovirus

Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiviral immune responses, and contributes to lifelong persistence within infected hosts. The low sequence identity between CMVIL-10 and cIL-10 suggests vaccination with CMVIL-10 may generate antibodies that specifically neutralize CMVIL-10 biological activity, but not the cellular cytokine, cIL-10. However, immunization with functional CMVIL-10 might be detrimental to the host because of its immunosuppressive properties.Structural biology was used to engineer biologically inactive mutants of CMVIL-10 that would, upon vaccination, elicit a potent immune response to the wild-type viral cytokine. To test the designed proteins, the mutations were incorporated into the rhesus cytomegalovirus (RhCMV) ortholog of CMVIL-10 (RhCMVIL-10) and used to vaccinate RhCMV-infected rhesus macaques. Immunization with the inactive RhCMVIL-10 mutants stimulated antibodies against wild-type RhCMVIL-10 that neutralized its biological activity, but did not cross-react with rhesus cellular IL-10.This study demonstrates an immunization strategy to neutralize RhCMVIL-10 biological activity using non-functional RhCMVIL-10 antigens. The results provide the methodology for targeting CMVIL-10 in vaccine, and therapeutic strategies, to nullify HCMV's ability to (1) skew innate and adaptive immunity, (2) disseminate from the site of primary mucosal infection, and (3) establish a lifelong persistent infection