NOE: a neutrino experiment for the CERN-Gran Sasso Long Base line project

The project of a large underground experiment (NOE) devoted to long baseline neutrino oscillation measurement is presentedComment: 7 pages, 9 figures, Talk at 5th International Workshop on Tau Lepton Physics (TAU98), To be published in Nucl. Phys. B, Proc. Supp

Full Characterization of the First 1 Inch Industrial Prototype of a New Concept Photodetector

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an original design for an innovative light detector we proposed with the aim to create new scientific instrumentation for industrial applications and physics research. The idea behind this device is to replace the classical dynode chain of a photomultiplier tube with a silicon photomultiplier, the latter acting as an electron detector and amplifier. The VSiPMT offers very attractive features and unprecedented performance, definitely superior to every other photodetector with comparable sensitive surface, such as: negligible power cosumption, excellent photon counting, easy low-voltage-based stabilization and very good time performance. After the feasibility test of the idea, Hamamatsu Photonics realized for our research group two VSiPMT industrial prototypes, that have been fully characterized. The results of the full characterization of the 1-inch industrial prototype are presented in this work.Comment: 11 pages, 14 figure

The luminous late-time emission of the type Ic supernova iPTF15dtg - evidence for powering from a magnetar?

iPTF15dtg is a Type Ic supernova (SN) showing a broad light curve around maximum light, consistent with massive ejecta if we assume a radioactive-powering scenario. We study the late-time light curve of iPTF15dtg, which turned out to be extraordinarily luminous for a stripped-envelope (SE) SN. We compare the observed light curves to those of other SE SNe and also with models for the $^{56}$Co decay. We analyze and compare the spectra to nebular spectra of other SE SNe. We build a bolometric light curve and fit it with different models, including powering by radioactivity, magnetar powering, as well as a combination of the two. Between 150 d and 750 d past explosion, iPTF15dtg's luminosity declined by merely two magnitudes instead of the six magnitudes expected from $^{56}$Co decay. This is the first spectroscopically-regular SE SN showing this behavior. The model with both radioactivity and magnetar powering provides the best fit to the light curve and appears to be the more realistic powering mechanism. An alternative mechanism might be CSM interaction. However, the spectra of iPTF15dtg are very similar to those of other SE SNe, and do not show signs of strong CSM interaction. iPTF15dtg is the first spectroscopically-regular SE SN whose light curve displays such clear signs of a magnetar contributing to the powering of the late time light curve. Given this result, the mass of the ejecta needs to be revised to a lower value, and therefore the progenitor mass could be significantly lower than the previously estimated $>$35 $M_{\odot}$.Comment: 9 pages, 8 figures, accepted for publication in Astronomy and Astrophysic

Gross chemical profile and calculation of nitrogen-to-protein conversion factors for five tropical seaweeds.

Despite decades of research on marine algae, there are still significant gaps in basic knowledge about chemical com-position of these organisms, especially in tropical environments. In this study, the amino acid composition and contents of total nitrogen, phosphorus, lipid, carbohydrate and protein were determined in Asparagopsis taxiformis, Centroceras clavulatum, Chaetomorpha aerea, Sargassum filipendula and Spyridia hypnoides. The seaweeds showed low lipid con-tents (lower than 5.5% d.w. in all species) and were rich in carbohydrates (more than 16% d.w. in all seaweeds). The percentage of nitrogen, phosphorus and protein varied widely among species, which red algae showed the highest con-centrations. The amino acid composition was similar among the seaweeds, which glutamic acid, aspartic acid and leu-cine as the most abundant. All species are poor in histidine. An average of 24.2% of the total nitrogen is non-proteinaceous. From data of total amino acid and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors calculated ranged from 4.51 to 5.21, with an overall average of 4.86. These findings show that the traditional conversion factor of 6.25 should be avoided for seaweeds, since it overestimates the actual protein content

Topological Devil's staircase in atomic two-leg ladders

We show that a hierarchy of topological phases in one dimension - a topological Devil's staircase - can emerge at fractional filling fractions in interacting systems, whose single-particle band structure describes a topological or a crystalline topological insulator. Focusing on a specific example in the BDI class, we present a field-theoretical argument based on bosonization that indicates how the system, as a function of the filling fraction, hosts a series of density waves. Subsequently, based on a numerical investigation of the low-lying energy spectrum, Wilczek-Zee phases, and entanglement spectra, we show that they are symmetry protected topological phases. In sharp contrast to the non-interacting limit, these topological density waves do not follow the bulk-edge correspondence, as their edge modes are gapped. We then discuss how these results are immediately applicable to models in the AIII class, and to crystalline topological insulators protected by inversion symmetry. Our findings are immediately relevant to cold atom experiments with alkaline-earth atoms in optical lattices, where the band structure properties we exploit have been recently realized

Experimental study of fusion neutron and proton yields produced by petawatt-laser-irradiated D2-3He or CD4-3He clustering gases

We report on experiments in which the Texas Petawatt laser irradiated a mixture of deuterium or deuterated methane clusters and helium-3 gas, generating three types of nuclear fusion reactions: D(d, 3He)n, D(d, t)p and 3He(d, p)4He. We measured the yields of fusion neutrons and protons from these reactions and found them to agree with yields based on a simple cylindrical plasma model using known cross sections and measured plasma parameters. Within our measurement errors, the fusion products were isotropically distributed. Plasma temperatures, important for the cross sections, were determined by two independent methods: (1) deuterium ion time-of-flight, and (2) utilizing the ratio of neutron yield to proton yield from D(d, 3He)n and 3He(d, p)4He reactions, respectively. This experiment produced the highest ion temperature ever achieved with laser-irradiated deuterium clusters.Comment: 16 pages, 6 figure

MicroRNA as Possible Mediators of the Synergistic Effect of Celecoxib and Glucosamine Sulfate in Human Osteoarthritic Chondrocyte Exposed to IL-1β

This study investigated the role of a pattern of microRNA (miRNA) as possible mediators of celecoxib and prescription-grade glucosamine sulfate (GS) effects in human osteoarthritis (OA) chondrocytes. Chondrocytes were treated with celecoxib (1.85 µM) and GS (9 µM), alone or in combination, for 24 h, with or without interleukin (IL)-1β (10 ng/mL). Cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, apoptosis and reactive oxygen species (ROS) by cytometry, nitric oxide (NO) by Griess method. Gene levels of miRNA, antioxidant enzymes, nuclear factor erythroid (NRF)2, and B-cell lymphoma (BCL)2 expressions were analyzed by quantitative real time polymerase chain reaction (real time PCR). Protein expression of NRF2 and BCL2 was also detected at immunofluorescence and western blot. Celecoxib and GS, alone or in combination, significantly increased viability, reduced apoptosis, ROS and NO production and the gene expression of miR-34a, -146a, -181a, -210, in comparison to baseline and to IL-1β. The transfection with miRNA specific inhibitors significantly counteracted the IL-1β activity and potentiated the properties of celecoxib and GS on viability, apoptosis and oxidant system, through nuclear factor (NF)-κB regulation. The observed effects were enhanced when the drugs were tested in combination. Our data confirmed the synergistic anti-inflammatory and chondroprotective properties of celecoxib and GS, suggesting microRNA as possible mediators

MicroRNA as Possible Mediators of the Synergistic Effect of Celecoxib and Glucosamine Sulfate in Human Osteoarthritic Chondrocyte Exposed to IL-1β

This study investigated the role of a pattern of microRNA (miRNA) as possible mediators of celecoxib and prescription-grade glucosamine sulfate (GS) effects in human osteoarthritis (OA) chondrocytes. Chondrocytes were treated with celecoxib (1.85 µM) and GS (9 µM), alone or in combination, for 24 h, with or without interleukin (IL)-1β (10 ng/mL). Cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, apoptosis and reactive oxygen species (ROS) by cytometry, nitric oxide (NO) by Griess method. Gene levels of miRNA, antioxidant enzymes, nuclear factor erythroid (NRF)2, and B-cell lymphoma (BCL)2 expressions were analyzed by quantitative real time polymerase chain reaction (real time PCR). Protein expression of NRF2 and BCL2 was also detected at immunofluorescence and western blot. Celecoxib and GS, alone or in combination, significantly increased viability, reduced apoptosis, ROS and NO production and the gene expression of miR-34a, -146a, -181a, -210, in comparison to baseline and to IL-1β. The transfection with miRNA specific inhibitors significantly counteracted the IL-1β activity and potentiated the properties of celecoxib and GS on viability, apoptosis and oxidant system, through nuclear factor (NF)-κB regulation. The observed effects were enhanced when the drugs were tested in combination. Our data confirmed the synergistic anti-inflammatory and chondroprotective properties of celecoxib and GS, suggesting microRNA as possible mediators

Temperature measurements of fusion plasmas produced by petawatt laser-irradiated D2-3He or CD4-3He clustering gases

Two different methods have been employed to determine the plasma temperature in a laser-cluster fusion experiment on the Texas Petawatt laser. In the first, the temperature was derived from time-of-flight data of deuterium ions ejected from exploding D2 or CD4 clusters. In the second, the temperature was measured from the ratio of the rates of two different nuclear fusion reactions occurring in the plasma at the same time: D(d, 3He)n and 3He(d, p)4He. The temperatures determined by these two methods agree well, which indicates that: i) The ion energy distribution is not significantly distorted when ions travel in the disassembling plasma; ii) The kinetic energy of deuterium ions, especially the hottest part responsible for nuclear fusion, is well described by a near-Maxwellian distribution.Comment: 13 pages, 4 figure