Methods for searching UHECR anisotropies with the Pierre Auger Observatory

The Pierre Auger Observatory, currently under construction, is a detector of Ultra-Hight Energy Cosmic Rays (UHECR), which will allow to study the highest-energy particles with unprecedented statistics . The aim of this paper is to present methods wich are currently under development within the Auger Collaboration to study possible anisotropies of UHECR which are a major key to understand their origin

Recent results from the Pierre Auger Observatory

The main results from the Auger Observatory are described. A steepening of the spectrum is observed at the highest energies, supporting the expectation that above $4\times 10^{19}$ eV the cosmic ray energies are significantly degraded by interactions with the CMB photons (the GZK effect). This is further supported by the correlations observed above $6\times 10^{19}$ eV with the distribution of nearby active galaxies, which also show the potential of Auger to start the era of charged particle astronomy. The lack of observation of photons or neutrinos strongly disfavors top-down models, and these searches may approach in the long term the sensitivity required to test the fluxes expected from the secondaries of the very same GZK process. Bounds on the anisotropies at EeV energies contradict hints from previous experiments that suggested a large excess from regions near the Galactic centre or the presence of a dipolar type modulation of the cosmic ray flux.Comment: 6 p., 8 figs., proceedings of the XXIII International Conference on Neutrino Physics and Astrophysics (Neutrino 08

Analysis of the root system architecture of Arabidopsis provides a quantitative readout of crosstalk between nutritional signals

As plant roots forage the soil for food and water, they translate a multifactorial input of environmental stimuli into a multifactorial developmental output that manifests itself as root system architecture (RSA). Our current understanding of the underlying regulatory network is limited because root responses have traditionally been studied separately for individual nutrient deficiencies. In this study, we quantified 13 RSA parameters of Arabidopsis thaliana in 32 binary combinations of N, P, K, S, and light. Analysis of variance showed that each RSA parameter was determined by a typical pattern of environmental signals and their interactions. P caused the most important single-nutrient effects, while N-effects were strongly light dependent. Effects of K and S occurred mostly through nutrient interactions in paired or multiple combinations. Several RSA parameters were selected for further analysis through mutant phenotyping, which revealed combinations of transporters, receptors, and kinases acting as signaling modules in K–N interactions. Furthermore, nutrient response profiles of individual RSA features across NPK combinations could be assigned to transcriptionally coregulated clusters of nutrient-responsive genes in the roots and to ionome patterns in the shoots. The obtained data set provides a quantitative basis for understanding how plants integrate multiple nutritional stimuli into complex developmental programs

Ultra-High Energy Cosmic Rays and the GeV-TeV Diffuse Gamma-Ray Flux

Ultra-high energy cosmic ray protons accelerated in astrophysical objects produce secondary electromagnetic cascades during propagation in the cosmic microwave and infrared backgrounds. We show that such cascades can contribute between ~1% and ~50% of the GeV-TeV diffuse photon flux measured by the EGRET experiment. The GLAST satellite should have a good chance to discover this flux.Comment: 4 pages, 5 figure

Lorentz Violation for Photons and Ultra-High Energy Cosmic Rays

Lorentz symmetry breaking at very high energies may lead to photon dispersion relations of the form omega^2=k^2+xi_n k^2(k/M_Pl)^n with new terms suppressed by a power n of the Planck mass M_Pl. We show that first and second order terms of size xi_1 > 10^(-14) and xi_2 < -10^(-6), respectively, would lead to a photon component in cosmic rays above 10^(19) eV that should already have been detected, if corresponding terms for electrons and positrons are significantly smaller. This suggests that Lorentz invariance breakings suppressed up to second order in the Planck scale are unlikely to be phenomenologically viable for photons.Comment: 4 revtex pages, 3 postscript figures included, version published in PR

The representation of dust transport and missing urban sources as major issues for the simulation of PM episodes in a Mediterranean area

Due to its adverse effects on human health, atmospheric particulate matter (PM) constitutes a growing challenge for air quality management. It is also a complex subject of study. The understanding of its atmospheric evolution is indeed made difficult by the wide number of sources and the numerous processes that govern its evolution in the troposphere. As a consequence, the representation of particulate matter in chemistry-transport models needs to be permanently evaluated and enhanced in order to refine our comprehension of PM pollution events and to propose consistent environmental policies. The study presented here focuses on two successive summer particulate pollution episodes that occurred on the French Mediterranean coast. We identify and analyze the constitutive elements of the first and more massive episode and we discuss their representation within a eulerian model. &lt;br&gt;&lt;br&gt; The results show that the model fails in reproducing the variability and the amplitude of dust import from western Africa, and that it constitutes a strong bias in PM daily forecasts. We then focus on the lack of diurnal variability in the model, which is attributed to missing urban sources in standard emission inventories, and notably the resuspension of particles by urban road traffic. Through a sensitivity study based on PM and NO&lt;sub&gt;x&lt;/sub&gt; measurements, we assess the sensitivity of PM to local emissions and the need to reconsider road traffic PM sources. In parallel, by coupling the CHIMERE-DUST model outputs to our simulation, we show that the representation of transcontinental dust transport allows a much better representation of atmospheric particles in southern France, and that it is needed in the frame of air quality management for the quantification of the anthropogenic part of particulate matter pollution

Endothelial Progenitor Cells Dysfunctions and Cardiometabolic Disorders: From Mechanisms to Therapeutic Approaches.

Metabolic syndrome (MetS) is a cluster of several disorders, such as hypertension, central obesity, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease. Despite health policies based on the promotion of physical exercise, the reduction of calorie intake and the consumption of healthy food, there is still a global rise in the incidence and prevalence of MetS in the world. This phenomenon can partly be explained by the fact that adverse events in the perinatal period can increase the susceptibility to develop cardiometabolic diseases in adulthood. Individuals born after intrauterine growth restriction (IUGR) are particularly at risk of developing cardiovascular diseases (CVD) and metabolic disorders later in life. It has been shown that alterations in the structural and functional integrity of the endothelium can lead to the development of cardiometabolic diseases. The endothelial progenitor cells (EPCs) are circulating components of the endothelium playing a major role in vascular homeostasis. An association has been found between the maintenance of endothelial structure and function by EPCs and their ability to differentiate and repair damaged endothelial tissue. In this narrative review, we explore the alterations of EPCs observed in individuals with cardiometabolic disorders, describe some mechanisms related to such dysfunction and propose some therapeutical approaches to reverse the EPCs dysfunction