Two Heads are Better than One: Single Pilot Operation Threatens the Safety of the Friendly Skies

Boeing’s Maneuvering Characteristics Augmentation System (“MCAS”), an automated piloting system, is only supposed to handle aircraft operations in very specific circumstances. Despite devasting results with MCAS, Boeing has another automated piloting system on the horizon that poses even more grave risks: Single Pilot Operation (“SPO”). Boeing—alon

Telemedicine of family-based treatment for adolescent anorexia nervosa: A protocol of a treatment development study.

BackgroundFamily-based treatment is an efficacious treatment available for adolescents with anorexia nervosa. Yet the implementation of this treatment, at least in the United States, is challenging due to a limited number of trained family-based treatment therapists and the concentration of these therapists in a limited number of urban centers. The use of telemedicine in the delivery of family-based treatment can increase access to this therapy for this patient population.Methods/designThis two-year treatment development study (December 2013-November 2015) follows a two-wave iterative case series design. The study is ongoing and addresses the treatment needs of families in remote, rural, or underrepresented parts of the United States by delivering family-based treatment via telemedicine (video chat). The first six months of the study was dedicated to selecting a cloud-based secure telemedicine portal for use with participants. Recruitment for the first of two consecutive case series (N = 5) began during month seven. After these five patients completed treatment, a systematic review of treatment via feedback from participants and therapists related to the delivery of this model and use of technology was completed. A second wave of recruitment is underway (N = 5). At the end of both waves (N = 10), and after a second review of treatment, we should be able to establish the feasibility and acceptability of family-based treatment delivered via telemedicine for this patient population.DiscussionThis study is the first attempt to deliver family-based treatment for adolescents with anorexia nervosa via telemedicine. If delivering family-based treatment in this format is feasible, it will provide access to an evidence-based treatment for families heretofore unable to participate in specialist treatment for their child's eating disorder

Diagnosing Tropical Cyclone Rapid Intensification Through Rotated Principal Component Analysis of Synoptic-Scale Diagnostic Fields

Forecasts of rapid intensification (RI) within tropical cyclones continue to be a major challenge, primarily due to difficulty in determining the processes that distinguish RI and non-RI storms. In this study, the aim was to identify the most important RI/non-RI discriminatory variables in the North Atlantic basin, not only by level, but also spatial location relative to the tropical cyclone center. These important variables, identified using rotated principal component analysis on one-dimensional and three-dimensional GEFS reforecast base-state variables from 1985 to 2009, led to the identification of diagnostic fields with the largest variability between RI and non-RI events. Hierarchical clustering techniques performed on rotated PC loadings provided map types of RI and non-RI cyclones. Analysis of these composite map types, as well as composite derived fields including divergence, relative vorticity, equivalent potential temperature, static stability, and vertical shear, revealed interesting distinguishing characteristics between RI and non-RI events. Results suggested that vorticity in the mid-levels, divergence in the upper-levels, equivalent potential temperature, and specific humidity play critical roles in successfully discriminating between RI and non-RI storms. These findings give key insights to which variables should be used in developing a prognostic classification scheme to assist with operational forecasts of tropical cyclone RI

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.

Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we show that GSDME-N also permeabilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome. Cytochrome c release and caspase-3 activation in response to intrinsic and extrinsic apoptotic stimuli are significantly reduced in GSDME-deficient cells comparing with wild type cells. GSDME deficiency also accelerates cell growth in culture and in a mouse model of melanoma. Phosphomimetic mutation of the highly conserved phosphorylatable Thr6 residue of GSDME, inhibits its pore-forming activity, thus uncovering a potential mechanism by which GSDME might be regulated. Like GSDME-N, inflammasome-generated gasdermin D-N (GSDMD-N), can also permeabilize the mitochondria linking inflammasome activation to downstream activation of the apoptosome. Collectively, our results point to a role of gasdermin proteins in targeting the mitochondria to promote cytochrome c release to augment the mitochondrial apoptotic pathway

Recruitment and baseline characteristics of the Community of Voices choir study to promote the health and well-being of diverse older adults.

Objective:To describe the recruitment and baseline results of the Community of Voices study that aims to examine the effect of a community choir intervention on the health and well-being of older adults from diverse racial/ethnic and socioeconomic backgrounds. Method:Using community-based participatory research methods, we recruited adults age 60 and over from 12 Administration on Aging-supported senior centers in San Francisco into a 2-arm cluster-randomized controlled trial of the community choir intervention. Multiple outreach methods were used. We tracked outreach, screening, and recruitment metrics and collected demographics and baseline outcomes via community-based, interviewer-administered surveys and performance measures of cognition, physical function, and psychosocial variables. Results:The study contacted 819 individuals, screened 636, and enrolled 390 diverse older adults over a 42-month, phased recruitment period. The mean age was 71.2 (SD = 7.3), and the majority were women. Two-thirds of the sample are non-white, and 20% of participants reported having financial hardship. Discussion:Outreach and recruitment methods used in the Community of Voices trial facilitated enrollment of a large proportion of minority and lower-SES older adults in the final sample. Similar recruitment approaches could serve as a model for recruiting diverse racial/ethnic and socioeconomic older adults into research

Using a Contextual Effects Measurement Approach to Understand the Influence of Community on Individual Behavior

A social organization perspective identifies processes operating in the community that may influence an individual’s behavior. To understand such processes, researchers can apply a contextual effects measurement approach, which is used to assess the influence of group-level effects on lower level outcomes. However, few community studies employ this approach. The purpose of this article is to present and evaluate the merits of the contextual effects measurement approach