Particle filtering for joint symbol and code delay estimation in DS spread spectrum systems in multipath environment

We develop a new receiver for joint symbol, channel characteristics, and code delay estimation for DS spread spectrum systems under conditions of multipath fading. The approach is based on particle filtering techniques and combines sequential importance sampling, a selection scheme, and a variance reduction technique. Several algorithms involving both deterministic and randomized schemes are considered and an extensive simulation study is carried out in order to demonstrate the performance of the proposed methods.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Messy methods: Making sense of participatory research with young people in PE and sport

Participatory research with young people has become an approach increasingly adopted by researchers within PE and sport. In this paper, we draw on our research diaries to collectively reflect on our experiences of attempting to work in participatory ways. Although we each work with different young people and have adopted differing participatory approaches, there are similarities in our research experiences. This includes recurring accounts of ‘muddling through’ and messiness occupying our reflections. We are also struck by the absence of concern within the literature to reveal the messiness of research. In light of our shared musings about participatory research with different young people, this paper offers some preliminary thoughts about our experiences of dealing with this messiness. We take as our focus the increasing concerns to support rights-based research that advocates inclusion, participation and empowerment, and draw on our research to explore how these features were worked towards. In these discussions we are open about the limitations of the research, challenges encountered and the resultant messiness arising. Our conclusion turns to what it might mean if researchers were more transparent about the usually unpredictable, messy and confusing situations that arise in the practice of doing participatory research with young people

The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers.

Nanocrystal budesonide (nanobudesonide) is a suspension for nebulization in patients with steroid-responsive pulmonary diseases such as asthma. The pharmacokinetics and safety of the product were compared to those of Pulmicort Respules. Sixteen healthy volunteers were administered nanobudesonide 0.5 and 1.0 mg, Pulmicort Respules 0.5 mg, and placebo in a four-way, randomized crossover design. All nebulized formulations were well tolerated, with no evidence of bronchospasm. Nebulization times were significantly shorter for nanobudesonide compared to Pulmicort Respules. Because of a low oral bioavailability, plasma concentration of budesonide is a good marker of lung-delivered dose. The pharmacokinetics of nanobudesonide 0.5 and 1.0 mg were approximately dose proportional with respect to Cmax, AUC(0-t), and AUC(0-infinity). Nanobudesonide 0.5 mg and Pulmicort Respules 0.5 mg exhibited similar AUCs, suggesting a similar extent of pulmonary absorption. A higher Cmax was noted with nanobudesonide 0.5 mg, and the tmax was significantly different, suggesting a more rapid rate of drug delivery of nanobudesonide 0.5 mg than Pulmicort Respules. In conclusion, nebulized nanobudesonide 0.5 mg was safe in healthy volunteers, with a similar extent of absorption as Pulmicort Respules

Doubly Special Relativity with a minimum speed and the Uncertainty Principle

The present work aims to search for an implementation of a new symmetry in the space-time by introducing the idea of an invariant minimum speed scale ($V$). Such a lowest limit $V$, being unattainable by the particles, represents a fundamental and preferred reference frame connected to a universal background field (a vacuum energy) that breaks Lorentz symmetry. So there emerges a new principle of symmetry in the space-time at the subatomic level for very low energies close to the background frame ($v\approx V$), providing a fundamental understanding for the uncertainty principle, i.e., the uncertainty relations should emerge from the space-time with an invariant minimum speed.Comment: 10 pages, 8 figures, Correlated paper in: http://www.worldscientific.com/worldscinet/ijmpd?journalTabs=read. arXiv admin note: substantial text overlap with arXiv:physics/0702095, arXiv:0705.4315, arXiv:0709.1727, arXiv:0805.120

Acceptability and Feasibility of Web-based Diabetes Instruction for Latinos with Limited Education and Computer Experience

Introduction: The internet offers an important avenue for developing diabetes self-management skills, but many Latinos have limited experience with computer-based instruction. Objective: To evaluate the feasibility and acceptability of delivering a web-based diabetes education program in a computer classroom for Spanish-speaking Latinos. Methods: Spanish-speaking Latinos (n=26) attended two classroom sessions to learn computer skills while navigating a web-based diabetes education platform. Diabetes knowledge was assessed before and after the intervention; structured interviews were completed to assess program acceptability. Results: Half of participants (50%) had not previously used a computer. Post-intervention, diabetes knowledge improved significantly (p=.001). The majority of participants (86%) indicated a preference for web-based instruction as a stand-alone program or as an adjunct to traditional classroom training, particularly citing the advantage of being able to engage the material at their own pace. Conclusion: With limited support, Latinos with minimal computer experience can effectively engage in web-based diabetes education

A Ring of Warm Dust in the HD 32297 Debris Disk

We report the detection of a ring of warm dust in the edge-on disk surrounding HD 32297 with the Gemini-N/MICHELLE mid-infrared imager. Our N'-band image shows elongated structure consistent with the orientation of the scattered-light disk. The Fnu(11.2 um) = 49.9+/-2.1 mJy flux is significantly above the 28.2+/-0.6 mJy photosphere. Subtraction of the stellar point spread function reveals a bilobed structure with peaks 0.5"-0.6" from the star. An analysis of the stellar component of the SED suggests a spectral type later than A0, in contrast to commonly cited literature values. We fit three-dimensional, single-size grain models of an optically thin dust ring to our image and the SED using a Markov chain Monte Carlo algorithm in a Bayesian framework. The best-fit effective grain sizes are submicron, suggesting the same dust population is responsible for the bulk of the scattered light. The inner boundary of the warm dust is located 0.5"-0.7" (~65 AU) from the star, which is approximately cospatial with the outer boundary of the scattered-light asymmetry inward of 0.5". The addition of a separate component of larger, cooler grains that provide a portion of the 60 um flux improves both the fidelity of the model fit and consistency with the slopes of the scattered-light brightness profiles. Previous indirect estimates of the stellar age (~30 Myr) indicate the dust is composed of debris. The peak vertical optical depths in our models (~0.3-1 x 1e-2) imply that grain-grain collisions likely play a significant role in dust dynamics and evolution. Submicron grains can survive radiation pressure blow-out if they are icy and porous. Similarly, the inferred warm temperatures (130-200 K) suggest that ice sublimation may play a role in truncating the inner disk.Comment: ApJ accepted, 8 pages, 4 figure

Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi

SETTING: Public sector facilities in Malawi providing antiretroviral therapy (ART) to human immunodeficiency virus (HIV) positive patients, including those with tuberculosis (TB). OBJECTIVES: To compare 6-month and 12-month cohort treatment outcomes of HIV-positive TB patients and HIV-positive non-TB patients treated with ART. DESIGN: Retrospective data collection using ART patient master cards and ART patient registers. RESULTS: Between July and September 2005, 7905 patients started ART, 6967 with a non-TB diagnosis and 938 with a diagnosis of active TB. 6-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (77%) compared with non-TB patients (71%) (P < 0.001). Between January and March 2005, 4580 patients started ART, 4179 with a non-TB diagnosis and 401 with a diagnosis of active TB. 12-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (74%) compared with non-TB patients (66%) (P < 0.001). Other outcomes of default and transfer out were also significantly less frequent in TB compared with non-TB patients. CONCLUSION: HIV-positive TB patients on ART in Malawi have generally good treatment outcomes, and more patients need to access this HIV treatment