Asymptotic Level Spacing of the Laguerre Ensemble: A Coulomb Fluid Approach

We determine the asymptotic level spacing distribution for the Laguerre Ensemble in a single scaled interval, $(0,s)$, containing no levels, E_{\bt}(0,s), via Dyson's Coulomb Fluid approach. For the $\alpha=0$ Unitary-Laguerre Ensemble, we recover the exact spacing distribution found by both Edelman and Forrester, while for $\alpha\neq 0$, the leading terms of $E_{2}(0,s)$, found by Tracy and Widom, are reproduced without the use of the Bessel kernel and the associated Painlev\'e transcendent. In the same approximation, the next leading term, due to a ``finite temperature'' perturbation (\bt\neq 2), is found.Comment: 10pp, LaTe

Student midwives' perspectives on the efficacy of feedback after objective structured clinical examination

Students’ experience of feedback is considered an indicator of the efficacy of the assessment process. Negative experiences of feedback are unproductive in terms of the likelihood that students will act upon and learn from assessment. To understand the impact of feedback on learning this study explored the experiences of student midwives after receiving feedback following Objective Structured Clinical Examination (OSCE). Data were collected from second year undergraduate student midwives who had recently completed OSCE, via a focus group. Students reported raised stress levels, concerns around legitimacy of feedback, and inconsistencies in the manner in which feedback was articulated. Assessment feedback in higher education should be used to empower students to become self-regulated learners. This is important for student midwives for whom a considerable amount of leaning is spent in practice. The study has implications for midwifery academics concerned with modes of assessment and quality of assessment feedback in midwifery education

The Cosmological Constant From The Viewpoint Of String Theory

The mystery of the cosmological constant is probably the most pressing obstacle to significantly improving the models of elementary particle physics derived from string theory. The problem arises because in the standard framework of low energy physics, there appears to be no natural explanation for vanishing or extreme smallness of the vacuum energy, while on the other hand it is very difficult to modify this framework in a sensible way. In seeking to resolve this problem, one naturally wonders if the real world can somehow be interpreted in terms of a vacuum state with unbroken supersymmetry.Comment: 12 pp., Lecture at DM2000, new reference and more conservative scenario adde

Anthropic tuning of the weak scale and of m_u/m_d in two-Higgs-doublet models

It is shown that in a model in which up-type and down-type fermions acquire mass from different Higgs doublets, the anthropic tuning of the Higgs mass parameters can explain the fact that the observed masses of the $d$ and $u$ quarks are nearly the same with $d$ slightly heavier. If Yukawa couplings are assumed not to "scan" (vary among domains), this would also help explain why the t quark is much heavier than the b quark. It is also pointed out that the existence of dark matter invalidates some earlier anthropic arguments against the viability of domains where the Standard Model Higgs has positive $\mu^2$, but makes other even stronger arguments possible.Comment: 31 pages, 7 figure

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics

Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conformation of the ruthenium centres is controlled by the stereochemical configuration of 1,2-diphenylethylenediamine linker moieties, as confirmed by X-ray crystallography. The reactivity and cytotoxicity of these compounds is compared to flexible dinuclear and mononuclear analogues, demonstrating in all cases the complexes can undergo aquation, coordinate to typical biological donor ligands and importantly, in the case of dinuclear analogues, crosslink oligonucleotide and peptide sequences. Differences in the conformation of the isomeric dinuclear compounds lead to significantly different levels of cytotoxicity against A2780, A2780cisR and HEK-293 cell lines; isomers with a closed conformation are significantly more cytotoxic than isomers with a more open conformation and they are also significantly less susceptible to acquired resistance mechanisms operating in the A2780cisR cell line. These rigid dinuclear compounds possess markedly increased cytotoxicity relative to the non-cytotoxic mononuclear analogues that does not appear to be related to differences in complex lipophilicity or cellular uptake, which, in general, remain similar in magnitude across the series. Thus, the molecular conformation of such dinuclear species may be crucial in determining the nature of the adducts formed on coordination to biological targets in a cellular environment, and opens up a novel route toward the development of more active metal-based anticancer agents

Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the development of an organometallic ruthenium compound, functionalized through a η6-bound arene ligand with a bicyclononyne derivative, able to participate in strain-promoted cycloaddition reactions with tetrazines. We show that combination of the ruthenium compound with a ditetrazine in biological media results in the in situ formation of a dinuclear molecule that is more cytotoxic toward cancer cells than the starting mononuclear ruthenium compound and tetrazine components. Such an approach may be extended to in vivo applications to construct a cytotoxic metallodrug at a tumor site, providing a novel approach toward the turn-on cytotoxicity of metallodrugs in the treatment of cancer

Models relating the radio emission and ionised gas in Seyfert nuclei

Possible models are discussed in which the radio emitting components in Seyfert II nuclei can compress and accelerate the ambient nuclear medium to produce the characteristics of the narrow line region. A first order model, which considers only the expansion of the radio components, is briefly described. However, in many Seyfert nuclei it appears that the linear motion of the radio components is also important. This can result in shock heating of the ambient medium, and if the cooling time is long enough, can lead to a displacement between the radio component and the associated emission lines. This effect may be present in NGC 1068 and NGC 5929 and by considering ram pressure balance and the cooling length it is possible to estimate lobe velocities and ambient densities

Action research in physical education: focusing beyond myself through cooperative learning

This paper reports on the pedagogical changes that I experienced as a teacher engaged in an action research project in which I designed and implemented an indirect, developmentally appropriate and child‐centred approach to my teaching. There have been repeated calls to expunge – or at least rationalise – the use of traditional, teacher‐led practice in physical education. Yet despite the advocacy of many leading academics there is little evidence that such a change of approach is occurring. In my role as teacher‐as‐researcher I sought to implement a new pedagogical approach, in the form of cooperative learning, and bring about a positive change in the form of enhanced pupil learning. Data collection included a reflective journal, post‐teaching reflective analysis, pupil questionnaires, student interviews, document analysis, and non‐participant observations. The research team analysed the data using inductive analysis and constant comparison. Six themes emerged from the data: teaching and learning, reflections on cooperation, performance, time, teacher change, and social interaction. The paper argues that cooperative learning allowed me to place social and academic learning goals on an even footing, which in turn placed a focus on pupils’ understanding and improvement of skills in athletics alongside their interpersonal development

The tails in the Helix Nebula NGC 7293

We have examined a stream-source model for the production of the cometary tails observed in the Helix Nebula NGC 7293 in which a transonic or moderately supersonic stream of ionized gas overruns a source of ionized gas. Hydrodynamic calculations reveal velocity structures which are in good agreement with the observational data on tail velocities and are consistent with observations of the nebular structure. The results also are indicative of a stellar atmosphere origin for the cometary globules. Tail remnants persist for timescales long enough for their identification with faint striations visible in the nebula gas to be plausible.Comment: 7 pages, 6 figures, accepted for publication in A&

The Formation of Broad Emission Line Regions in Supernova-QSO Wind Interactions

We show that a cooled region of shocked supernova ejecta forms in a type II supernova-QSO wind interaction, and has a density, an ionization parameter, and a column density compatible with those inferred for the high ionization component of the broad emission line regions in QSOs. The calculations are based on the assumption that the ejecta flow is described initially by a similarity solution investigated by Chevalier (1982) and Nadyozhin (1985) and is spherically symmetric. Heating and cooling appropriate for gas irradiated by a nearby powerful continuum source is included in our model, together with reasonable assumptions for the properties of the QSO wind. The model results are also in agreement with observational correlations and imply reasonable supernova rates.Comment: 13 pages, 7 figures, to be published in A&