Prognostic Significance of HER2 Gene Amplification According to Stage of Breast Cancer

It is well known that the amplification of the HER2 gene is closely associated with poor prognosis of breast cancer. However, there is controversy about the clinical significance of HER2 according to lymph node status in breast cancer. The aim of this study was to identify the differences in the prognostic significance of HER2 gene amplification according to the stages of breast cancer. We prepared a tissue array for fluorescence in situ hybridization (FISH) with breast cancer specimens from the surgery in 1994 to 1999. Total 338 cases of breast cancer were enrolled and the median follow-up period was 6.3 yr. The detection rates of HER2 gene amplification were as follows: 10.3% in stage I, 22.3% in stage II, and 43.8% in stage III. On survival analyses HER2-positive groups showed worse prognosis in stage III of breast cancer, but not in stage I or II. Multivariate analyses with a Cox-regression model also revealed that HER2 amplification was an independent prognostic factor only in stage III breast cancer. Regarding HER2 gene amplification as a prognostic factor of breast cancer, the clinical significance of the gene was found to be confined to advanced breast cancer

The contradictory politics of the right to travel: mobilities, borders & tourism

The freedom of movement and right to travel are intrinsic to the growth of international tourism. Notwithstanding the inchoate nature of the right to tourism, the entitlement to travel and to pursue tourism without hindrance is firmly established in advanced capitalist societies. Moreover, the right to tourism has been recently enshrined in the 2017 United Nations World Tourism Organisation (UNWTO) Framework Convention on Tourism Ethics. Tourists’ ease of mobility contrasts starkly with the movements of less privileged forms of mobility that may be variously constrained by racism, xenophobia and restrictive border controls. This paper contends that rather than a mere reflection of accumulated political rights (citizenship), such unequal and differentiated mobilities are conditioned by a complex assemblage of discursive frameworks and structural forces that are played out in specific historical-geographic contexts. Accordingly, we argue that the rights associated with global tourism must be analysed in the context of the contradictory politics of global mobility, or indeed in terms of the ‘mobility crisis’. This ‘crisis’ is one that is rooted in and shaped by the cumulative legacy of past colonial orders, global capitalism and geopolitical realignments, in addition to multi-scalar systems of governance through which borders are constituted, managed and policed

Tensile Properties of Sea Ice Grown in a Confined System

International Conference on Low Temperature Science. I. Conference on Physics of Snow and Ice, II. Conference on Cryobiology. (August, 14-19, 1966, Sapporo, Japan

Where Christ Dies Daily: Performances of Faith at Orlando‘s Holy Land Experience

This manuscript focuses on performances of place and faith inside the Holy Land Experience (HLE), an edutainment complex nestled in the fantasy nexus of Orlando, Florida. A self-proclaimed living-history museum, the HLE includes animatronic Bible characters and musical dramas. The HLE enacts and embodies evangelical narratives of Christianity and Christian faith, and visitors to the park are asked to join the performances, blurring the distinctions between spectators and professional actors. I argue that visitors\u27 performances of faith invest the space of the HLE with sacredness, while the location and design of the HLE infuses the space with elements of the secular. The HLE exemplifies the performative nature of the sacred and shows how sacredness is a process (a performance), not an inherent property. Through participant observation, interviews, and critical/cultural analysis, I engage the multiple meanings of the HLE with the intention of facilitating empathic understandings of the complex, embodied phenomenon of faith as it manifests in this hybrid space

Abraham Lincoln

Address presented at the Opera house, Streator, Illinois, February 12, 1909, at invitation of G.A.R. Woman\u27s Relief Corps, Spanish-American veterans, and the Daughters of the American Revolution; A brief review of Lincoln\u27s career.https://scholarsjunction.msstate.edu/fvw-pamphlets/1371/thumbnail.jp

Where Christ Dies Daily: Performances of Faith at Orlando‘s Holy Land Experience

This manuscript focuses on performances of place and faith inside the Holy Land Experience (HLE), an edutainment complex nestled in the fantasy nexus of Orlando, Florida. A self-proclaimed living-history museum, the HLE includes animatronic Bible characters and musical dramas. The HLE enacts and embodies evangelical narratives of Christianity and Christian faith, and visitors to the park are asked to join the performances, blurring the distinctions between spectators and professional actors. I argue that visitors\u27 performances of faith invest the space of the HLE with sacredness, while the location and design of the HLE infuses the space with elements of the secular. The HLE exemplifies the performative nature of the sacred and shows how sacredness is a process (a performance), not an inherent property. Through participant observation, interviews, and critical/cultural analysis, I engage the multiple meanings of the HLE with the intention of facilitating empathic understandings of the complex, embodied phenomenon of faith as it manifests in this hybrid space