Attribute Signatures: Dynamic Visual Summaries for Analyzing Multivariate Geographical Data

The visual analysis of geographically referenced datasets with a large number of attributes is challenging due to the fact that the characteristics of the attributes are highly dependent upon the locations at which they are focussed, and the scale and time at which they are measured. Specialized interactive visual methods are required to help analysts in understanding the characteristics of the attributes when these multiple aspects are considered concurrently. Here, we develop attribute signatures -- interactively crafted graphics that show the geographic variability of statistics of attributes through which the extent of dependency between the attributes and geography can be visually explored. We compute a number of statistical measures, which can also account for variations in time and scale, and use them as a basis for our visualizations. We then employ different graphical configurations to show and compare both continuous and discrete variation of location and scale. Our methods allow variation in multiple statistical summaries of multiple attributes to be considered concurrently and geographically, as evidenced by examples in which the census geography of London and the wider UK are explored

Interactive Generation of Visual Summaries for Multivariate Geographical Data Analysis

The visual analysis of geographically referenced datasets with a large number of attributes is challenging due to the fact that the characteristics of the attributes are highly dependent upon the locations at which they are focussed and the scale at which they are measured. Here, we develop attribute signatures – interactively crafted graphics that show the geographic variability of statistics of attributes through which the extent of dependency between the attributes and geography can be visually explored. We compute a number of statistical measures and use them as a basis for our visualizations. Our methods allow variation in multiple statistical summaries of multiple attributes to be considered concurrently and geographically, as evidenced by an example in which the census geography of two cities in UK are explored

A and B antigen levels acquired by group O donor-derived erythrocytes following ABO-non-identical transfusion or minor ABO-incompatible haematopoietic stem cell transplantation

BACKGROUND AND OBJECTIVES: ABO-incompatible haematopoietic stem cell transplantation (HSCT) presents a challenge to blood component transfusion. The aim of this study was to investigate the weak blood group A or B antigen expression by donor-derived group O red blood cells (RBC) observed following transfusion or minor ABO-incompatible HSCT. In addition, in vitro experiments were performed to elucidate possible mechanisms underlying this phenomenon.MATERIALS AND METHODS: A sensitive flow cytometry assay for the semi-quantification of RBC A/B antigen levels was used to assess patient samples and evaluate in vitro experiments.RESULTS: Analysis of blood samples from patients, originally typed as A, B and AB but recently transplanted or transfused with cells from group O donors, revealed the A antigen expression on donor-derived RBC, ranging from very low levels in non-secretor individuals to almost subgroup Ax -like profiles in group A secretors. The B antigen expression was less readily detectable. In vitro experiments, in which group O donor RBC were incubated with (i) group A/B secretor/non-secretor donor plasma or (ii) group A/B donor RBC in the absence of plasma, supported the proposed adsorption of A/B antigen-bearing glycolipids from secretor plasma but also indicated a secretor-independent mechanism for A/B antigen acquisition as well as direct cell-to-cell transfer of ABO antigens.CONCLUSION: The in vivo conversion of donor-derived blood group O RBC to ABO subgroup-like RBC after transfusion or minor ABO-incompatible HSCT raises the question of appropriate component selection. Based on these data, AB plasma should be transfused following ABO-incompatible HSCT

GeoVisual analytics: interactivity, dynamics, and scale

3D desktop-based virtual environments provide a means for displaying quantitative data in context. Data that is inherently spatial in three-dimensions may benefit from visual exploration and analysis in relation to the environment in which they were collected and to which they relate. We empirically evaluate how effectively and efficiently such data can be visually analyzed in relation to location and landform in 3D versus 2D visualizations. In two experiments, participants performed visual analysis tasks in 2D and 3D visualizations and reported insights and their confidence in them. The results showed only small differences between the 2D and 3D visualizations in the performance measures that we evaluated: task completion time, confidence, complexity, and insight plausibility. However, we found differences for different data sets and settings suggesting that 3D visualizations, or 2D representations respectively, may be more or less useful for particular data sets and contexts

Visual Analysis of Pressure in Football

Modern movement tracking technologies enable acquisition of high quality data about movements of the players and the ball in the course of a football match. However, there is a big difference between the raw data and the insights into team behaviors that analysts would like to gain. To enable such insights, it is necessary first to establish relationships between the concepts characterizing behaviors and what can be extracted from data. This task is challenging since the concepts are not strictly defined. We propose a computational approach to detecting and quantifying the relationships of pressure emerging during a game. Pressure is exerted by defending players upon the ball and the opponents. Pressing behavior of a team consists of multiple instances of pressure exerted by the team members. The extracted pressure relationships can be analyzed in detailed and summarized forms with the use of static and dynamic visualizations and interactive query tools. To support examination of team tactics in different situations, we have designed and implemented a novel interactive visual tool “time mask”. It enables selection of multiple disjoint time intervals in which given conditions are fulfilled. Thus, it is possible to select game situations according to ball possession, ball distance to the goal, time that has passed since the last ball possession change or remaining time before the next change, density of players’ positions, or various other conditions. In response to a query, the analyst receives visual and statistical summaries of the set of selected situations and can thus perform joint analysis of these situations. We give examples of applying the proposed combination of computational, visual, and interactive techniques to real data from games in the German Bundesliga, where the teams actively used pressing in their defense tactics

vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments

<p>Abstract</p> <p>Background</p> <p>The replication rate (or fitness) between viral variants has been investigated <it>in vivo </it>and <it>in vitro </it>for human immunodeficiency virus (HIV). HIV fitness plays an important role in the development and persistence of drug resistance. The accurate estimation of viral fitness relies on complicated computations based on statistical methods. This calls for tools that are easy to access and intuitive to use for various experiments of viral fitness.</p> <p>Results</p> <p>Based on a mathematical model and several statistical methods (least-squares approach and measurement error models), a Web-based computing tool has been developed for improving estimation of virus fitness in growth competition assays of human immunodeficiency virus type 1 (HIV-1).</p> <p>Conclusions</p> <p>Unlike the two-point calculation used in previous studies, the estimation here uses linear regression methods with all observed data in the competition experiment to more accurately estimate relative viral fitness parameters. The dilution factor is introduced for making the computational tool more flexible to accommodate various experimental conditions. This Web-based tool is implemented in C# language with Microsoft ASP.NET, and is publicly available on the Web at <url>http://bis.urmc.rochester.edu/vFitness/</url>.</p

EDTA Registry Centre Survey, 1986: Report from the European Dialysis and Transplant Association Registry

This paper summarises the information given on the 1986 EDTA Registry centre questionnaire which was returned by 82% of the 2,065 known dialysis and transplant centres in 33 European countries. Information is given on the number of patients alive on haemodialysis according to the type of dialysis facilities available where the patient was receiving dialysis and the number of patients receiving special types of dialysis. The centre questionnaire also included questions on testing for HIV infection, serological evidence or symptoms of AIDS and the diagnosis of hepatitis B in patients and staff. The data given in response to these questions are presented together with data on the involvement of dietitians and social workers in the treatment of patients with end stage renal failure. Finally, information on transplant activity in Europe and the treatment policies of transplanting centres is provide

Kidney Transplantation in Primary Oxalosis: Data From the EDTA Registry

This paper reports the results of 98 first kidney transplantations in patients with oxalosis as the primary renal disease as recorded by the EDTA Registry. There were 79 patients who received a cadaveric (CAD) graft and 15 patients with a living related donor (LRD) graft; the type of donor was not recorded for four patients. Initial graft survival appeared to be better after LRD as compared to CAD grafts but at 3 years the poor survival was similar with 23% for LRD and 17% for CAD grafts. CAD graft survival did not differ between children and adults and was not affected by the waiting time on dialysis. A slight improvement was observed in grafts performed in the years 1983-1986 as compared to grafts performed in earlier years. The causes of failure reported were mainly rejection (33%) and recurrence of primary renal disease (31%). In view of the poor results related to recurrence of oxalosis in the graft, the potential ofcombined kidney and liver transplantation is discusse