Fully integrated continuous antibody processing demonstrates improved productivity

Continuous processing has been an important topic in the biopharmaceutical industry for the past few years. However, as this technology is still at an early stage, continuous processing has remained largely siloed to individual steps with little thought towards combining each stage to create a fully continuous process. This presentation will show a fully integrated continuous process, from production bioreactor to drug substance at pilot scale, as well as touch on considerations for manufacturing costs and facility throughput. Specific emphasis will be given towards the production perfusion bioreactor, capture using multicolumn chromatography, viral inactivation, and buffer exchange

Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants

Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research

Renewable Resource Integration Project - Scoping Study of Strategic Transmission, Operations, and Reliability Issues

California is on a path to increase utilization of renewable resources. California will need to integrate approximately 30,000 megawatts (MW) of new renewable generation in the next 20 years. Renewable resources are typically located in remote locations, not near the load centers. Nearly two/thirds or 20,000 MW of new renewable resources needed are likely to be delivered to Los Angeles Basin transmission gateways. Integration of renewable resources requires interconnection to the power grid, expansion of the transmission system capability between the backbone power grid and transmission gateways, and increase in delivery capacity from transmission gateways to the local load centers. To scope the transmission, operations, and reliability issues for renewables integration, this research focused on the Los Angeles Basin Area transmission gateways where most of new renewables are likely. Necessary actions for successful renewables integration include: (1) Expand Los Angeles Basin Area transmission gateway and nomogram limits by 10,000 to 20,000 MW; (2) Upgrade local transmission network for deliverability to load centers; (3) Secure additional storage, demand management, automatic load control, dynamic pricing, and other resources that meet regulation and ramping needed in real time operations; (4) Enhance local voltage support; and (5) Expand deliverability from Los Angeles to San Diego and Northern California

Carbon Footprint of Beef Cattle

ABSTRACT: The carbon footprint of beef cattle is presented for Canada, The United States, The European Union, Australia and Brazil. The values ranged between 8 and 22 kg CO(2)e per kg of live weight (LW) depending on the type of farming system, the location, the year, the type of management practices, the allocation, as well as the boundaries of the study. Substantial reductions have been observed for most of these countries in the last thirty years. For instance, in Canada the mean carbon footprint of beef cattle at the exit gate of the farm decreased from 18.2 kg CO(2)e per kg LW in 1981 to 9.5 kg CO(2)e per kg LW in 2006 mainly because of improved genetics, better diets, and more sustainable land management practices. Cattle production results in products other than meat, such as hides, offal and products for rendering plants; hence the environmental burden must be distributed between these useful products. In order to do this, the cattle carbon footprint needs to be reported in kg of CO(2)e per kg of product. For example, in Canada in 2006, on a mass basis, the carbon footprint of cattle by-products at the exit gate of the slaughterhouse was 12.9 kg CO(2)e per kg of product. Based on an economic allocation, the carbon footprints of meat (primal cuts), hide, offal and fat, bones and other products for rendering were 19.6, 12.3, 7 and 2 kg CO(2)e per kg of product, respectively

Prospectus, December 7, 1976

VACCINATIONS GIVEN: 580 RECEIVE SWINE FLU SHOTS; 8 cents asked for: Tax vote go-ahead given; Display case almost ready; Reid will leave: Stu-Go busy before break; PC news in brief: Christian booktable, Get away…, Possible Hawks-Flyers tickets, Parkland Sociological Association, Skiing anyone?; To the Students of Parkland College...; Letters to the editor: \u27Be true\u27, \u27Toys for Tots\u27 thanks, Letter of thanks, Will piano haul students from annex of learning?; \u27No Vacancy\u27 at Bethlehem Ho-Jo: New version of Nativity told; Washington clamps down: Vets must attend to collect benefits; Prospectus wins; Save yourself: Still time for \u27W,\u27 not \u27F\u27; ALS courses available at Lab; It\u27s \u27sno trouble: Crew keeps campus clear; Apple Tree auditions through Thursday; Workshop-Tea Wed.; Mark Twain: Cast \u27live\u27 their characters; Students, teacher find that bird in hand no easy task; Krannert lists Dec.; Paxton hosts chamber music; West Springfield Avenue\u27s new businesses attract Parkland students; Parkland College 1976-1977 Basketball Schedule; Cagers play seven games before Christmas; Chillbains?: Getting here - the hard way; Dotted landscape: Bugged by red beetles at PC; PC campus site is named CCDC award winner; Classifieds; Sports editorial: Moeller - the program he\u27ll have to change; 1-2 for year: Cobras go against Olney tonight; Women\u27s Basketball Schedule; Lake County new team: Women\u27s first opponents \u27unknown\u27https://spark.parkland.edu/prospectus_1976/1000/thumbnail.jp

Prospectus, September 21, 1976

PC BOARD OF TRUSTEES OKS DEFICIT BUDGET; Anna Dearing of the LS testing lab: I enjoy it ; Write-ins dominate election, 1st Stu-Go meeting tommorow; PC news in brief: Sociological Association, First Meeting, Yea team!!!, Need some help?, Basketball tryouts; Women\u27s program sponsors : Antonia ; Improve reading at PC; Letters to the editor: The pins, Again..., And again?..., Oh no! not again?..., Give a Schmidt!!!, Where are the sports?; Editorial: Students are consumers; Quad fest featured music, magic; Counselors comply with Title IX; Prairie Festival set for Sunday; Louise Parker: \u27People are fun to watch\u27; Auditions today, tomorrow; Summer school in the Rockies; Drag races teach needed skills; 45 students attend: Marriott\u27s Great America attracts Parkland field trip; Ike\u27s opinion: Controversy continues: feedback on Dr. Richards; Uncle Bob: Slinging vegies is old tradition; Country crowd: Charlie and his fans; Mark Twain; Mediaseen: Carter and the media; Classifieds; Hoofers do \u27extremely well\u27 at UI; Women\u27s volleyball schedule; Locks and Dam 26 is subject of Oct. 12 debate; Know your athletes: \u27T\u27 Square keeps on running to own beat; Ten men: C-C members listed; Cobra\u27s Corner: Women\u27s volleyball improves; Cross Country Schedule 1976; Golfers fourth in tourney; Lose your nose?; Know your athletes: Kathy Kaler prepares for teaching; Linton wins Fast Fred; Fast Freddy\u27s Football Forecast; Games of September 25https://spark.parkland.edu/prospectus_1976/1011/thumbnail.jp

Prospectus, October 12, 1976

STUDENTS WANT \u27PINS\u27; \u27You can help your child to read\u27: Oct. 19; PC news in brief: Bridge Club, Tickets on sale till noon, Blazing saddles, Vet Tech bake sale, Fly away, Hunting symposium, Baha\u27i Club, Scott Shearer speaks; Stu-Go: Get to know us: Free food, drink, good conversation; AMVA visits Vet Tech; FCC Oks PC radio; Letters to the Editor: Sad lot of the parker, Different frequencies?; Editorial: Tickets deny \u27due process\u27; Editorial: Education can be different; Staff editorial: Death penalty more murder; Library assistants take it with smiles; Readers Theatre: Rehearsals start for series; English teachers confer; Audubon film set for October 25th; Gibson nursing session today; SIU Home Ec will host guest day; First in line: Sally will finally see Elvis Presley; Pam Fritz: Music frees the soul; Charlie K. moving on down; Thursday college forums set; Facts for Transferring PC students; A \u27mystic feeling\u27; Nadia: Belly dancing; Mrs. Warren\u27s Profession: Shaw\u27s message is strong; Uncle Bob: Armory plays free; PC faculty concert Sunday; Parkland women outnumber men; Mediaseen: Community Broadcasters to meet; Classifieds; Know your athletes: Ike: \u27I like to do everything\u27; IM Football Schedules; Faculty bowling: Watch out for \u27Excess\u27; Duffers place 14th at Joliet: Harriers take 5th in PC Invit.; \u27Terrible outing\u27; Green grabs Fast Freddy again; Fast Freddy\u27s Football Forecast; This Week\u27s Scores; Spikers lose to EIU first loss of the season; Games of October 16https://spark.parkland.edu/prospectus_1976/1008/thumbnail.jp

Water Security for Climate Resilience Report: A synthesis of research from the Oxford University REACH programme

This report presents a synthesis of published and ongoing research by REACH which explores the relationship between water security, climate and climate adaptation decisions, drawing on findings from REACH research conducted in Sub-Saharan Africa and South Asia. We demonstrate the unequal impact of climate on water security, and on people’s lives and livelihoods, which can be counter-intuitive to broad narratives around resilience and adaptation. We exemplify the impact of seasonal fluctuations in weather on surface and groundwater quality and quantity, and show that water security risks evolve with shifting climate conditions, water use behaviours, and policy decisions. We also present a deepened understanding of location- and context specific climate issues and dynamics, revealing a pressing need to consider and plan for different distributional impacts of climate and climate change

‘It's all the way you look at it, you know’: reading Bill ‘Bojangles’ Robinson's film career

This paper engages with a major paradox in African American tap dancer Bill ‘Bojangles’ Robinson's film image – namely, its concurrent adherences to and contestations of dehumanising racial iconography – to reveal the complex and often ambivalent ways in which identity is staged and enacted. Although Robinson is often understood as an embodiment of popular cultural imagery historically designed to dehumanise African Americans, this paper shows that Robinson's artistry displaces these readings by providing viewing pleasure for black, as much as white, audiences. Robinson's racially segregated scenes in Dixiana (1930) and Hooray for Love (1935) illuminate classical Hollywood's racial codes, whilst also showing how his inclusion within these otherwise all-white films provides grounding for creative and self-reflexive artistry. The films' references to Robinson's stage image and artistry overlap with minstrelsy-derived constructions of ‘blackness’, with the effect that they heighten possible interpretations of his cinematic persona by evading representational conclusion. Ultimately, Robinson's films should be read as sites of representational struggle that help to uncover the slipperiness of performances of African American identities in 1930s Hollywood