41 research outputs found
Analytic models of plausible gravitational lens potentials
Gravitational lenses on galaxy scales are plausibly modelled as having
ellipsoidal symmetry and a universal dark matter density profile, with a Sersic
profile to describe the distribution of baryonic matter. Predicting all lensing
effects requires knowledge of the total lens potential: in this work we give
analytic forms for that of the above hybrid model. Emphasising that complex
lens potentials can be constructed from simpler components in linear
combination, we provide a recipe for attaining elliptical symmetry in either
projected mass or lens potential. We also provide analytic formulae for the
lens potentials of Sersic profiles for integer and half-integer index. We then
present formulae describing the gravitational lensing effects due to
smoothly-truncated universal density profiles in cold dark matter model. For
our isolated haloes the density profile falls off as radius to the minus fifth
or seventh power beyond the tidal radius, functional forms that allow all
orders of lens potential derivatives to be calculated analytically, while
ensuring a non-divergent total mass. We show how the observables predicted by
this profile differ from that of the original infinite-mass NFW profile.
Expressions for the gravitational flexion are highlighted. We show how
decreasing the tidal radius allows stripped haloes to be modelled, providing a
framework for a fuller investigation of dark matter substructure in galaxies
and clusters. Finally we remark on the need for finite mass halo profiles when
doing cosmological ray-tracing simulations, and the need for readily-calculable
higher order derivatives of the lens potential when studying catastrophes in
strong lenses.Comment: 24 pages, 10 figures, matches published versio
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
DLG4-related synaptopathy: a new rare brain disorder
PURPOSE: Postsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53 patients (42 previously unpublished) with DLG4 variants.METHODS: The clinical and genetic information were collected through GeneMatcher collaboration. All the individuals were investigated by local clinicians and the gene variants were identified by clinical exome/genome sequencing.RESULTS: The clinical picture was predominated by early onset global developmental delay, intellectual disability, autism spectrum disorder, and attention deficit-hyperactivity disorder, all of which point to a brain disorder. Marfanoid habitus, which was previously suggested to be a characteristic feature of DLG4-related phenotypes, was found in only nine individuals and despite some overlapping features, a distinct facial dysmorphism could not be established. Of the 45 different DLG4 variants, 39 were predicted to lead to loss of protein function and the majority occurred de novo (four with unknown origin). The six missense variants identified were suggested to lead to structural or functional changes by protein modeling studies.CONCLUSION: The present study shows that clinical manifestations associated with DLG4 overlap with those found in other neurodevelopmental disorders of synaptic dysfunction; thus, we designate this group of disorders as DLG4-related synaptopathy.Genetics of disease, diagnosis and treatmen
Eddies and a mesoscale deflection of the slope current in the Faroe-Shetland Channel
The mesoscale dynamics of the Scottish side of the Faroe-Shetland Channel have been investigated using synoptic in situ and remote sensing observations. A cold core cyclonic eddy, identified from an AVHRR image, had a diameter of about 50 km and surface current speeds of up to 50 cm s; it appeared to be attached to the 800 m isobath as it moved north-eastward along the edge of the channel at about 8 cm s. Speeds in the slope current were about 50 cm s but increased to 70 cm s where the current was compressed by the eddy. Offshore, over the 1000 m isobath in the cooler water, speeds in the current were slower (ca. 20 cm s). North-west of the Shetlands the offshore edge of the slope current was deflected across the channel for a distance of about 70 km from the shelf edge. The speed of drifters in the slope current increased to over 60 cm s as they moved anti-cyclonically around this deflection. CTD profiles suggest that the movement of the surface waters was mirrored in the deep water of the channel. The deflection carried a very large quantity of North Atlantic Water into the central part of the channel; its cause and ultimate fate are not known, although it is likely to have had a significant impact on the dynamics of the channel