The effect of drug therapy on the uptake of radioactive fluorine by osseous metastases

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117024/1/cpt196785647.pd

A Tribute to William Burnett Harvey

The Board of Editors, in recognition of his lasting contributions as Dean of the Law School, hereby dedicates Volume 75 of the Indiana Law Journal to the memory of William Burnett Harve

SU(3) Breaking Effects in Hyperon Semi-Leptonic Decays and the extraction of F and D

The analysis of hyperon semi-leptonic decay data is re-examined in the light of a recent suggestion that SU(3) symmetry breaking effects may be taken into account by applying a correction to the $F/D$ ratio obtained via naive linear extrapolation in the hyperon masses. Comparison is made with the physically better motivated approach of applying so-called centre-of-mass corrections. This study (including all available data) reveals certain short-comings of the former of the above treatments, highlights some interesting aspects of this type of analysis and attempts to pinpoint the decay data that might usefully be improved. A tantalising result of the SU(3) breaking analysis performed here is that the magnitude of recoil correction required by the data corresponds closely to that required for the standard explanation of the reduction of \gA from its SU(6) value of 5/3. We also comment on other recent suggestions for taking into account the effects of SU(3) breaking. Finally a few remarks are made on the relevance for predicting the flavour non-singlet contribution to the proton $g_1$ and the Ellis-Jaffe sum rule.Comment: 12 pages, latex, no figures. Removed extended ascii set characters in the source file that were being corrupted by some mailer

Protocol for Future Amino Acid Analyses of Samples Returned by the Stardust Mission

We have demonstrated that LC-ToF-MS coupled with UV fluorescence detection is a powerful tool for the detection of amino acids in meteorite extracts. Using this new analytical technique we were able to identify the extraterrestrial amino acid AIB extracted from fifteen 20 micron sized Murchison meteorite grains. We found that the amino acid contamination levels in Stardust aerogels was much lower than the levels observed in the Murchison meteorite. In addition, the alpha-dialkyl amino acids AIB and isovaline which are the most abundant amino acids in Murchison were not detected in the aerogel above blank levels. We are currently integrating LIF detection capability to our existing nanoflow LC-ToF-MS for enhanced sensitivity required for the analysis of amino acids in Stardust samples

Broadcasting graphic war violence: the moral face of Channel 4

Drawing on empirical data from Channel 4 (C4) regarding the broadcasting of violent war imagery, and positioned within Goffman’s notion of the interaction ritual (1959, 1967), this article investigates how C4 negotiate potentially competing commercial, regulatory and moral requirements through processes of discretionary decision-making. Throughout, the article considers the extent to which these negotiations are presented through a series of ‘imaginings’ – of C4 and its audience – which serve to simultaneously guide and legitimate the decisions made. This manifestation of imaginings moves us beyond more blanket explanations of ‘branding’ and instead allows us to see the final programmes as the end product of a series of complex negotiations and interactions between C4 and those multiple external parties significant to the workings of their organization. The insights gleaned from this case study are important beyond the workings of C4 because they help elucidate how all institutions and organizations may view, organize and justify their practices (to both themselves and others) within the perceived constraints in which they operate

Individual Rights, Economic Transactions, and Recognition: A Legal Approach to Social Economics

Modernity brought the idea of individual property rights as a com- plex phenomenon. However, economics adopted a simplistic view of property as a fundamental institution, understating the complex interaction of different rights and obligations that frame the legal environment of economic processes with an insufficiently elaborated tool. Here, a more elaborate view of legal elements will be propose

Osteoarthritis and the rule of halves

<b>Background</b> Symptomatic osteoarthritis poses a major challenge to primary health care but no studies have related accessing primary care ("detection"), receiving recommended treatments ("treatment"), and achieving adequate control ("control").<p></p> <b>Objective</b> To provide estimates of detection, treatment, and control within a single population adapting the approach used to determine a Rule of Halves for other long-term conditions.<p></p> <b>Setting</b> General population.<p></p> <b>Participants</b> 400 adults aged 50+ years with prevalent symptomatic knee osteoarthritis.<p></p> <b>Design</b> Prospective cohort with baseline questionnaire, clinical assessment, and plain radiographs, and questionnaire follow-up at 18 and 36 months and linkage to primary care medical records.<p></p> <b>Outcome measures</b> "Detection" was defined as at least one musculoskeletal knee-related GP consultation between baseline and 36 months. "Treatment" was self-reported use of at least one recommended treatment or physiotherapy/hospital specialist referral for their knee problem at all three measurement points. Pain was "controlled" if characteristic pain intensity <5 out of 10 on at least two occasions.<p></p> <b>Results</b> In 221 cases (55.3%; 95%CI: 50.4, 60.1) there was evidence that the current problem had been detected in general practice. Of those detected, 164 (74.2% (68.4, 80.0)) were receiving one or more of the recommended treatments at all three measurement points. Of those detected and treated, 45 (27.4% (20.5, 34.3)) had symptoms under control on at least two occasions. Using narrower definitions resulted in substantially lower estimates.<p></p> <b>Conclusion</b> Osteoarthritis care does not conform to a Rule of Halves. Symptom control is low among those accessing health care and receiving treatment