uRT51: An Embedded Real-Time processor implemented on FPGA devices

In this paper we describe and evaluate the main features of the uRT51 processor. The uRT51 processor was designed for embedded realtime control applications. It is a processor architecture that incorporates the specific functions of a real-time system in hardware. It was described using synthesizable VHDL and it was implemented on FPGA devices. We describe how the uRT51 processor supports time, events, task and priorities. The performance of the uRT51 processor is evaluated using a control application as a case study. The experiments show that the uRT51 processor scheduling features outperform the ones obtained using a traditional RTOS-based real-time system.Fil: Cayssials, Ricardo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Duval, M,. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; ArgentinaFil: Ferro, Edgardo Carlos. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; ArgentinaFil: Alimenti, O.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; Argentin

The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L

AbstractPIAS proteins, cytokine-dependent STAT-associated repressors, exhibit intrinsic E3-type SUMO ligase activities and form a family of transcriptional modulators. Three conserved domains have been identified so far in this protein family, the SAP box, the MIZ-Zn finger/RING module and the acidic C-terminal domain, which are essential for protein interactions, DNA binding or SUMO ligase activity. We have identified a novel conserved domain of 180 residues in PIAS proteins and shown that its ‘PINIT’ motif as well as other conserved motifs (in the SAP box and in the RING domain) are independently involved in nuclear retention of PIAS3L, the long form of PIAS3, that we have characterized in mouse embryonic stem cells

Principal Component Analysis of Molecular Clouds: Can CO reveal the dynamics?

We use Principal Component Analysis (PCA) to study the gas dynamics in numerical simulations of typical MCs. Our simulations account for the non-isothermal nature of the gas and include a simplified treatment of the time-dependent gas chemistry. We model the CO line emission in a post-processing step using a 3D radiative transfer code. We consider mean number densities n_0 = 30, 100, 300 cm^{-3} that span the range of values typical for MCs in the solar neighbourhood and investigate the slope \alpha_{PCA} of the pseudo structure function computed by PCA for several components: the total density, H2 density, 12CO density, 12CO J = 1 -> 0 intensity and 13CO J = 1 -> 0 intensity. We estimate power-law indices \alpha_{PCA} for different chemical species that range from 0.5 to 0.9, in good agreement with observations, and demonstrate that optical depth effects can influence the PCA. We show that when the PCA succeeds, the combination of chemical inhomogeneity and radiative transfer effects can influence the observed PCA slopes by as much as ~ +/- 0.1. The method can fail if the CO distribution is very intermittent, e.g. in low-density clouds where CO is confined to small fragments.Comment: 12 pages, 8 figures, accepted for publication in MNRA

Twist Deformation of Rotationally Invariant Quantum Mechanics

Non-commutative Quantum Mechanics in 3D is investigated in the framework of the abelian Drinfeld twist which deforms a given Hopf algebra while preserving its Hopf algebra structure. Composite operators (of coordinates and momenta) entering the Hamiltonian have to be reinterpreted as primitive elements of a dynamical Lie algebra which could be either finite (for the harmonic oscillator) or infinite (in the general case). The deformed brackets of the deformed angular momenta close the so(3) algebra. On the other hand, undeformed rotationally invariant operators can become, under deformation, anomalous (the anomaly vanishes when the deformation parameter goes to zero). The deformed operators, Taylor-expanded in the deformation parameter, can be selected to minimize the anomaly. We present the deformations (and their anomalies) of undeformed rotationally-invariant operators corresponding to the harmonic oscillator (quadratic potential), the anharmonic oscillator (quartic potential) and the Coulomb potential.Comment: 20 page

Studies on the reactivity of a tertiary allylic alcohol in an acetophenonic series, a model for natural products synthesis

The synthesis of benzopyranic simplified analogues of dibenzopyranic natural compounds is described, together with the access to a precursor of a new furobenzopyranic natural product. These natural products have anti-cancer activity. The 1,3-diacetoxy-2-acetyl-4-(3-hydroxy-3-methylbut-1-enyl)benzene synthone is used as a common precursor to these structures

Paradoxical effects of the topoisomerase inhibitor, ethoxidine, in the cellular processes leading to angiogenesis on EaHy.926 endothelial cells

Topoisomerase I generates transient single-stranded breaks in DNA and have the capacity to fragment the genome. Thus, this enzyme is the target for some of the most successful anticancer drugs. Ethoxidine, a benzo[c]phenanthridines derivative, was identified as a potent inhibitor of topoisomerase I. As angiogenesis is a critical step in tumorigenesis, this study was designed to test the potential effect of ethoxidine on different processes leading to neovascularisation on EaHy endothelial cells including adhesion, migration and proliferation. Ethoxidine was tested at two concentrations, 100 μM and 10 μM . VEGF (20 ng/mL) was used as control. Adherent cells were evaluated using crystal violet staining, migration using a model of wound healing. Proliferation was analyzed using CyQUANT Cell Proliferation Assay Kit. Both O2- and NO productions were assessed using electronic paramagnetic resonance technique. All the effects of ethoxidine were evaluated at 24 h treatment. Low concentration of ethoxidine promoted migration to the same extent as that produced by VEGF whereas high concentration inhibited this process. Ethoxidine significantly enhanced adhesion at similar level than VEGF at low concentration. It was without effect at high concentration. Although ethoxidine had no effect at low concentration, it significantly reduced cell proliferation at high concentration. At any concentration tested, ethoxidine did not modify basal O2- production. Interestingly, ethoxidine significantly increase NO production at low concentration but it was without effect at high concentration. As control experiment, VEGF enhanced Eahy cells NO production under the same experimental conditions. Altogether, the present study highlights paradoxical effects of ethoxidine depending on the concentration used. At low concentration, it promotes both Eahy cells migration and adhesion without any effect on proliferation. Importantly, these effects were associated with an increase of NO production. In contrast at high concentration, ethoxidine reduced Eahy cells migration and proliferation but had no effect neither on adhesion nor NO release. Of note is the fact that ethoxidine did not alter endothelial cells oxidative stress at any concentration tested. Thus, these data underscore the potential anti-tumoral property of ethoxidine at high concentration and endothelial cells in the present study. The property of ethoxidine in inhibiting proliferation in both cell type probably account for its high antitumor activity

Aging and Holography

Aging phenomena are examples of `non-equilibrium criticality' and can be exemplified by systems with Galilean and scaling symmetries but no time translation invariance. We realize aging holographically using a deformation of a non-relativistic version of gauge/gravity duality. Correlation functions of scalar operators are computed using holographic real-time techniques, and agree with field theory expectations. At least in this setup, general aging phenomena are reproduced holographically by complexifying the bulk space-time geometry, even in Lorentzian signature.Comment: 1 pdf figur

On the Schrödinger-Newton equation and its symmetries: a geometric view

LaTeX 29 pages; minor correctionsInternational audienceThe \SN (SN) equation is recast on purely geometrical grounds, namely in terms of Bargmann structures over (\d+1)-dimensional Newton-Cartan (NC) spacetimes. Its maximal group of invariance, which we call the SN group, is determined as the group of conformal Bargmann automorphisms that preserve the coupled Schr\"odinger and NC gravitational field equations. Canonical unitary representations of the SN group are worked out, helping us recover, in particular, a very specific occurrence of dilations with dynamical exponent z=(\d+2)/3