Structure, Construction, and Geochemistry of the Cretaceous Seven-Fingered-Jack Intrusive Complex in the Klone Peak Area, North Cascades, Washington

The highly elongate Seven-Fingered-Jack intrusive complex (SFJIC) of the North Cascades, Washington provides an excellent opportunity to study the construction, geochemistry, and structure of a well-exposed mid-crustal pluton. The interior ~92 Ma Main Body tonalite has markedly heterogeneous and mafic domains that may represent interactions between multiple batches of melt. The ~78 Ma marginal Kelly Mountain suite includes a mafic complex containing abundant hornblendite, diorites of variable heterogeneity, and tonalite. Field mapping and structural, petrographic, and geochemical analyses are interpreted to indicate that this intrusive complex was built incrementally by many batches of melt. The dominantly NW-striking and NE-dipping magmatic foliation is overprinted by weak solid-state fabrics. The magmatic foliation is folded in both units and has N-NW hinge lines. These time-transgressive folds are consistent with regional contraction during and shortly after emplacement. Modal analysis by point-counting indicates that the dominant mafic mineral switches from biotite in the older tonalite to hornblende in the younger tonalite. This modal analysis coupled with XRF and ICP-MS geochemical analyses shows that although similar, the younger and older tonalites plot distinctly enough to indicate that they may be derived from different magma sources. Geochemical data also indicates that the Main Body tonalite likely has a shallower magma source than the coeval, but structurally deeper Tenpeak pluton

Strengthening the Relationship between Undergraduate Professional Preparation Programs in Parks, Recreation, and Tourism and Graduate Leisure Studies

This article stems from a conversation among academic leaders of graduate-oriented departments of parks, recreation, and tourism across North America who participated in an administrator summit at Zion Ponderosa Resort in southern Utah September 23-26, 2010. The University of Utah’s Department of Parks, Recreation, and Tourism hosted the summit, and among the many topics discussed was the need to strengthen the relationship between undergraduate professional preparation programs in parks, recreation, and tourism and graduate leisure studies. In many respects, the tension between undergraduate and graduate programs reflects the tension between research universities and the world of professional practice. We examine this tension in both contexts and recommend specific courses of action to relieve it

People and Nature: Toward an Ecological Model of Health Promotion

Striving for a healthier relationship among individuals, families, communities, nations, and the environment is imperative at a time in history when humankind can change the face of the earth in monumental ways. This dynamic health relationship, with an emphasis on the contributions of parks, recreation, and tourism to health promotion, is the subject of this article. A broader conception of health that moves beyond human physical and mental health to include familial, communal, national, international, and global ecological health is called for, and a more comprehensive ecological model of health promotion, including consideration of health from a holistic ecological perspective, is presented. New directions for leisure research based on an ecological orientation to health promotion conclude the article

Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single-cell transcriptomics, and T and B cell receptor repertoire analysis of right colon tissue from 65 patients with PSC, 108 patients with IBD and 48 healthy individuals we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia in patients with PSC. This inflammatory signature is characterized by antigen-driven interleukin-17A (IL-17A

Evaluating Elk Summer Resource Selection and Applications to Summer Range Habitat Management

In much of the west, National Forest lands are managed in part to provide and protect elk (Cervus elaphus) habitat needs, and summer elk habitat is managed with consideration to motorized routes. We evaluated the relative importance of nutritional resources, access routes and other landscape attributes on elk summer resource selection at multiple spatial scales.  Resource selection models for 9 different western Montana elk populations, as well are regional models using data from all 9 herds, were compared to determine the applicability of resource selection models for informing habitat management recommendations. We found thatin all populations nutritional resources, best represented using NDVI metrics, were the most important factors associated with elk summer resource selection. Access route disturbances, best represented by the density of all routes (i.e., routes open and closed to motorized use), affected resource selection in all populations, however, the influence of access routes was relatively small as compared to nutritional resources. Regional models of resource selection predicted resource selection across populations better than population-specific models, thus we recommend these types of models be used to inform regional habitat management. Our results suggest that managers should expand the current management paradigm for elk summer habitat to also consider nutritional resources as an important component of elk summer habitat. Time-integrated NDVI, an easily accessible and free data source, may be useful as an assessment tool to identify areas of optimal elk nutrition

Receipt of Guideline-Concordant Care Among Older Women With Stage I-III Breast Cancer: A Population-Based Study

Background: This study examined receipt of guideline-concordant care (GCC) according to evidence-based treatment guidelines and quality measures and specific types of treatment among older women with breast cancer. Patients and Methods: A total of 142,433 patients aged ≥66 years diagnosed with stage I–III breast cancer between 2007 and 2011 were identified in the SEER-Medicare linked database. Algorithms considering cancer characteristics and the appropriate course of care as per guidelines versus actual care received determined receipt of GCC. Multivariable logistic regression estimated the likelihood of GCC and specific types of treatment for women aged ≥75 versus 66 to 74 years. Results: Overall, 39.7% of patients received GCC. Patients diagnosed at stage II or III, with certain preexisting conditions, and of nonwhite race were less likely to receive GCC. Patients with hormone-negative tumors, higher grade tumors, and greater access to oncology care resources were more likely to receive GCC. Patients aged ≥75 years were approximately 40% less likely to receive GCC or adjuvant endocrine therapy, 78% less likely to have any surgery, 61% less likely to have chemotherapy, and about half as likely to have radiation therapy than those aged 66 to 74 years. Conclusions: Fewer than half of older women with breast cancer received GCC, with the lowest rates observed among the oldest age groups, racial/ethnic minorities, and women with later-stage cancers. However, patients with more aggressive tumor characteristics and greater access to oncology resources were more likely to receive GCC. Considering that older women have the highest incidence of breast cancer and that many are diagnosed at stages requiring more aggressive treatment, efforts to increase rates of earlier stage diagnosis and the development of less toxic treatments could help improve GCC and survival while preserving quality of life

Carotid Baroreflex Responses to Simulated Hypotension are Blunted During Passive Whole-body Heat Stress in Young Women

Previous studies have proposed that carotid baroreflex (CBR) function is potentially compromised during heat stress, thus possibly disrupting the ability to maintain arterial blood pressure in the heat (e.g., decreased orthostatic tolerance during hyperthermia). Recently, we demonstrated that CBR function is preserved, if not enhanced, during a passive whole-body heat stress (WBH) in young healthy men. What remains unknown is how CBR function is impacted by hyperthermia in women. PURPOSE: Therefore, the purpose of this study was to test the hypothesis that CBR-mediated responses are preserved during a passive WBH in young women. METHODS: Changes in mean arterial pressure (MAP) and HR were assessed in 7 healthy women (age: 21±1 yrs, height: 171±5 cm, weight: 66±5 kg, BMI: 23±2 kg/m2) using 5-s trials of neck pressure (NP, carotid hypotension) and neck suction (NS, carotid hypertension) ranging from +40 to -80 Torr during normothermia (NT) and WBH (increased core temp ~1.0 °C) conditions. To assess the CBR control of MAP and HR, a separate two-way repeated measures ANOVA was utilized for 1) hypertensive stimuli (i.e., NS: -20, -40, -60 & -80 Torr) and 2) hypotensive-stimuli (i.e., NP: +20 & +40 Torr). Additionally, the time-to-peak responses for HR and MAP, separately, in response +40 Torr & -80 Torr trials were examined between thermal conditions using paired t-tests. RESULTS: During WBH, the CBR-mediated increases in MAP and HR in response to NP were blunted (main effect of thermal condition p=0.02 and p=0.02, respectively). While the CBR-mediated decreases in MAP in response to NS were not different between thermal conditions (main effect of thermal condition p=0.34), decreases in HR were markedly greater during WBH (main effect of thermal condition p\u3c0.001). Additionally, the time-to-peak responses for MAP and HR were not altered between thermal conditions for either NP or NS trials (p \u3e 0.05 for all comparisons). CONCLUSION: Taken together, these data suggest the CBR control of MAP and HR during simulated hypotension is blunted in females during passive WBH, while the control of MAP and HR seems to be preserved, if not enhanced, during simulated hypertension. Contrary to our findings in young men, these results suggest there are sex differences in CBR function during WBH. This diminished ability to increase MAP and HR in response to a hypotensive stimulus during hyperthermia may be a key component in reduced orthostatic tolerance in females during WBH

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization. Our objectives were to measure insulin-sensitive glucose metabolism in neonatal lambs with IUGR and to determine whether daily treatment with ADRβ2 agonist and ADRβ1/β3 antagonists for 1 month normalizes their glucose metabolism. Growth, glucose-stimulated insulin secretion (GSIS) and glucose utilization rates (GURs) were measured in control lambs, IUGR lambs and IUGR lambs treated with adrenergic receptor modifiers: clenbuterol atenolol and SR59230A (IUGR-AR). In IUGR lambs, islet insulin content and GSIS were less than in controls; however, insulin sensitivity and whole-bodyGUR were not different from controls.Of importance, ADRβ2 stimulation with β1/β3 inhibition increases both insulin sensitivity and whole-body glucose utilization in IUGR lambs. In IUGR and IUGR-AR lambs, hindlimb GURs were greater but fractional glucose oxidation rates and ex vivo skeletal muscle glucose oxidation rates were lower than controls. Glucose transporter 4 (GLUT4) was lower in IUGR and IUGR-AR skeletal muscle than in controls but GLUT1 was greater in IUGR-AR. ADRβ2, insulin receptor, glycogen content and citrate synthase activity were similar among groups. In IUGR and IUGR-AR lambs heart rates were greater, which was independent of cardiac ADRβ1 activation. We conclude that targeted ADRβ2 stimulation improved whole-body insulin sensitivity but minimally affected defects in GSIS and skeletal muscle glucose oxidation. We show that risk factors for developing diabetes are independent of postnatal catch-up growth in IUGR lambs as early as 1 month of age and are inherent to the islets and myocytes

Islet Adaptations in Fetal Sheep Persist Following Chronic Exposure to High Norepinephrine

Complications in pregnancy elevate fetal norepinephrine (NE) concentrations. Previous studies in NE-infused sheep fetuses revealed that sustained exposure to high NE resulted in lower expression of α2-adrenergic receptors in islets and increased insulin secretion responsiveness after acutely terminating the NE infusion. In this study, we determined if the compensatory increase in insulin secretion following chronic elevation of NE is independent of hyperglycemia in sheep fetuses and whether it is persistent in conjunction with islet desensitization to NE. Following an initial assessment of glucose-stimulated insulin secretion (GSIS) at 129±1 days of gestation, fetuses were continuously infused for seven days with NE and maintained at euglycemia with a maternal insulin infusion. Fetal GSIS studies were again performed on days 8 and 12. Adrenergic sensitivity was determined in pancreatic islets collected at day 12. NE infusion increased (P\u3c0.01) fetal plasma NE concentrations and lowered (P\u3c0.01) basal insulin concentrations compared to vehicle-infused controls. GSIS was 1.8-fold greater (P\u3c0.05) in NE-infused fetuses compared to controls at both one and five days after discontinuing the infusion. Glucose-potentiated arginine-induced insulin secretion was also enhanced (P\u3c0.01) in NE-infused fetuses. Maximum GSIS in islets isolated from NE-infused fetuses was 1.6-fold greater (P\u3c0.05) than controls, but islet insulin content and intracellular calcium signaling were not different between treatments. The half-maximal inhibitory concentration for NE was 2.6-fold greater (P\u3c0.05) in NE-infused islets compared to controls. These findings show that chronic NE exposure and not hyperglycemia produce persistent adaptations in pancreatic islets that augment β-cell responsiveness in part through decreased adrenergic sensitivity