Unusual Closed Traumatic Avulsion of Both Flexor Tendons in Zones 1 and 3 of the Little Finger.

Closed tendon avulsion of both flexor tendons in the same finger is an extremely rare condition. We encountered the case of a patient who presented a rupture of the flexor digitorum profundus in zone 1 and flexor digitorum superficialis in zone 3 in the little finger. This occurrence has not been reported previously. We hereby present our case, make a review of the literature of avulsion of both flexor tendons of the same finger, and propose a treatment according to the site of the ruptures

Diversity of Xanthomonas hortorum pv. carotae, the agent of bacterial leaf blight of carrot and the need for a new pathotype strain

Xanthomonads are plant-associated bacteria responsible for diseases of considerable economic importance. While these bacteria spread by aerosols and mechanical means like infected pruning tools, the movement of contaminated seeds and other propagation material generally represents the main inoculum source for diseases due to xanthomonads. Plant health management of these diseases through sanitation practices and plant resistance mainly depends on reliable detection and identification tools. The genus Xanthomonas has been subject to numerous taxonomical and phylogenetic studies, but its taxonomy is still under active debate. Some of the relationships between pathovars and species have not been thoroughly clarified. Strains formerly part of one pathovar are now found in two different species, some pathovars need pathotype strains and others were left with unsuitable pathotypes. Bacterial leaf blight of carrot (Daucus carota L. subsp. sativus) is caused by Xanthomonas hortorum pv. carotae (Xhc), a seed-borne pathogen with a worldwide distribution. The pathotype for this pathovar was reported to be unsuitable in 1991. In order to test plant genetic material for resistance to this pathogen, we study the genetic diversity of strains within this pathovar. A large collection of Xhc strains and Xhc look-alikes isolated from carrots was established. A multilocus sequence analysis (MLSA) targeting six housekeeping genes revealed that Xhc strains cluster in two close genetic lineages sharing a common ancestor. Pathogenicity of strains representative of these lineages was confirmed. The low polymorphism revealed by these genes does not allow a thorough typing of strains. In contrast, a multilocus variable number of tandem repeats analysis (MLVA) yielded a large genetic diversity among strains of this pathovar that is useful for molecular epidemiology study of this disease. In contrast with Xhc strains, look-alikes split in various parts of the Xanthomonas phylogenetic tree. These strains are not pathogenic on carrots but most generally induce hypersensitive reaction on tobacco and possess a hrp-Type Three Secretion System. This polyphasic analysis of Xhc and look-alikes offer the opportunity to designate a neopathotype strain for Xhc, which will help future studies of strains belonging to this pathovar

A Simple n-Dimensional Intrinsically Universal Quantum Cellular Automaton

We describe a simple n-dimensional quantum cellular automaton (QCA) capable of simulating all others, in that the initial configuration and the forward evolution of any n-dimensional QCA can be encoded within the initial configuration of the intrinsically universal QCA. Several steps of the intrinsically universal QCA then correspond to one step of the simulated QCA. The simulation preserves the topology in the sense that each cell of the simulated QCA is encoded as a group of adjacent cells in the universal QCA.Comment: 13 pages, 7 figures. In Proceedings of the 4th International Conference on Language and Automata Theory and Applications (LATA 2010), Lecture Notes in Computer Science (LNCS). Journal version: arXiv:0907.382

Citizen advisory groups for the creation and improvement of decision aids: experience from two Swiss centers for primary care.

Guidelines for patient decision aids (DA) recommend target population involvement throughout the development process, but developers may struggle because of limited resources. We sought to develop a feasible means of getting repeated feedback from users. Between 2017 and 2020, two Swiss centers for primary care (Lausanne and Bern) created citizen advisory groups to contribute to multiple improvement cycles for colorectal, prostate and lung cancer screening DAs. Following Community Based Participatory Research principles, we collaborated with local organizations to recruit citizens aged 50 to 75 without previous cancer diagnoses. We remunerated incidental costs and participant time. One center supplemented in-person meetings by mailed paper questionnaires, while the other supplemented meetings using small-group workshops and analyses of meeting transcripts. In Lausanne, we received input from 49 participants for three DAs between 2017 and 2020. For each topic, participants gave feedback on the initial draft and 2 subsequent versions during in-person meetings with ~ 8 participants and one round of mailed questionnaires. In Bern, 10 participants were recruited among standardized patients from the university, all of whom attended in-person meetings every three months between 2017 and 2020. At both sites, numerous changes were made to the content, appearance, language, and tone of DAs and outreach materials. Participants reported high levels of satisfaction with the participative process. Citizen advisory groups are a feasible means of repeatedly incorporating end-user feedback during the creation of multiple DAs. Methodological differences between the two centers underline the need for a flexible model adapted to local needs

Combining default choices and an encounter decision aid to improve tobacco cessation in primary care patients: protocol for a cluster-randomized trial.

While quitting smoking dramatically decreases overall mortality, general practitioners (GPs) are less likely to prescribe medications for smoking cessation than other cardiovascular risk factors. Guidelines recommend providers first assess patients' "readiness" to quit, an "opt-in" strategy, but only a minority of tobacco users are ready to quit on a given day. An "opt-out" strategy offering treatment as the default choice increased quit attempts in hospital and with pregnant women, but has not been tested in primary care. We will assess the efficacy of training GPs to offer treatment as the default choice using an encounter decision aid with current smokers seen in primary care. This is a pragmatic cluster-randomized controlled superiority trial with block randomization at the GP level in private practice in French-speaking Switzerland. GPs will be blinded to the arm allocation. The intervention is a half-day training course teaching an 'opt-out' approach to smoking cessation using an encounter decision aid (paper or electronic). GPs in the enhanced usual care group receives a brief refresher training about smoking cessation without changing their behaviour. GPs in both arms will recruit 23 patients each prior to routine primary care visits. The primary outcome is the effect of consulting a GP who received the intervention on the 7-day, point prevalence, smoking abstinence 6 months after the baseline appointment. Secondary outcomes include continuous abstinence; number of quit attempts; use of smoking cessation aids; patient-perceived involvement in discussions; and changes in GP behaviour. Patient outcomes will be collected using paper and telephone questionnaires. Assuming 15% drop-out, recruiting 46 GPs with 23 patients each will give us 80% power to detect an increase in smoking cessation from 4% (control) to 10.5% (intervention), with an alpha < 0.05. GP visits are an opportunity to administer proven smoking cessation treatments. We hypothesize GPs offering smoking cessation treatment as the default choice using an encounter decision aid will increase the number of patients who quit. This study could significantly change our approach to smoking cessation in primary care. Default choices and the electronic decision aid are low-cost, easily diffusible interventions. ClinicalTrials.gov Identifier: NCT04868474, First Posted May 3, 2021, Last Update Posted October 6, 2021

Recombination-prone bacterial strains form a reservoir from which epidemic clones emerge in agroecosystems

The acquisition of virulence-related genes through horizontal gene transfer can modify the pathogenic profiles of strains and lead to the emergence of new diseases. Xanthomonas arboricola is a bacterial species largely known for the damage it causes to stone and nut fruit trees worldwide. In addition to these host-specific populations called pathovars, many nonpathogenic strains have been identified in this species. Their evolutionary significance in the context of pathogen emergence is unknown. We looked at seven housekeeping genes amplified from 187 pathogenic and nonpathogenic strains isolated from various plants worldwide to analyze population genetics and recombination dynamics. We also examined the dynamics of the gains and losses of genes associated with life history traits (LHTs) during X. arboricola evolution. We discovered that X. arboricola presents an epidemic population structure. Successful pathovars of trees (i.e. pruni, corylina and juglandis) are epidemic clones whose emergence appears to be linked to the acquisition of eight genes coding for Type III effectors. The other strains of this species are part of a recombinant network, within which LHT-associated genes might have been lost. We suggest that nonpathogenic strains, because of their high genetic diversity and propensity for recombination, may promote the emergence of pathogenic strains

Engaging Long-Term Care Workers in Research: Recruitment Approaches and Participant Characteristics From a Randomized Controlled Trial to Improve COVID-19 Vaccine Confidence.

To describe and compare the recruitment methods employed in a randomized controlled trial targeting long-term care workers, and resulting participant baseline characteristics. We used a multifaceted recruitment process to enroll long-term care workers in our 3-arm randomized controlled trial comparing 2 interventions to enhanced usual practice, for improving COVID-19 vaccine confidence and other outcomes. Adult long-term care workers living in the United States employed within the last 2 years were invited to join the study. Participants also had to meet specific screening criteria related to their degree of worry about the vaccine and/or their vaccination status. We used a participatory approach to engage our long-term care stakeholders in codesigning and executing a combination of recruitment methods, including targeted e-recruitment, paid e-recruitment, and in-person recruitment. Participants were screened, consented, and enrolled online. We implemented a participant verification process to ensure the integrity of our study data, and used a tailored participant management platform to manage enrollment. We enrolled 1930 long-term care workers between May 2022 and January 2023. We met our enrollment target, despite each recruitment method having limitations. Total variable costs of approximately $102,700 were incurred and differed on a per-enrolled participant basis across methods:$25.73 for targeted e-recruitment, $57.12 for paid e-recruitment, and$64.92 for in-person methods. Our sample differed from the national population in age, gender, race/ethnicity, education, and role in long-term care. Differences were also observed between online and in-person recruitment methods. Our results support the feasibility of enrolling a large number of long-term care workers in a randomized controlled trial to increase COVID-19 vaccine confidence. Findings build upon the evidence base for engaging this important population in research, a critical step to improving long-term care resident health and well-being. Results from our trial are anticipated in 2024

Global Relationships Between River Width, Slope, Catchment Area, Meander Wavelength, Sinuosity, and Discharge

Using river centerlines created with Landsat images and the Shuttle Radar Topography Mission digital elevation model, we created spatially continuous maps of mean annual flow river width, slope, meander wavelength, sinuosity, and catchment area for all rivers wider than 90 m located between 60°N and 56°S. We analyzed the distributions of these properties, identified their typical ranges, and explored relationships between river planform and slope. We found width to be directly associated with the magnitude of meander wavelength and catchment area. Moreover, we found that narrower rivers show a larger range of slope and sinuosity values than wider rivers. Finally, by comparing simulated discharge from a water balance model with measured widths, we show that power laws between mean annual discharge and width can predict width typically to −35% to +81%, even when a single relationship is applied across all rivers with discharge ranging from 100 to 50,000 m3/s

Multifragment production in Au+Au at 35 MeV/u

Multifragment disintegration has been measured with a high efficiency detection system for the reaction $Au + Au$ at $E/A = 35\ MeV$. From the event shape analysis and the comparison with the predictions of a many-body trajectories calculation the data, for central collisions, are compatible with a fast emission from a unique fragment source.Comment: 9 pages, LaTex file, 4 postscript figures available upon request from [email protected]. - to appear in Phys. Lett.

Octet magnetic moments and the Coleman-Glashow sum rule violation in the chiral quark model

Baryon octet magnetic moments when calculated within the chiral quark model, incorporating the orbital angular momentum as well as the quark sea contribution through the Cheng-Li mechanism, not only show improvement over the non relativistic quark model results but also gives a non zero value for the right hand side of Coleman-Glashow sum rule. When effects due to spin-spin forces between constituent quarks as well as `mass adjustments' due to confinement are added, it leads to an excellent fit for the case of p, \Sigma^+, \Xi^o and violation of Coleman-Glashow sum rule, whereas in almost all the other cases the results are within 5% of the data.Comment: 5 RevTeX pages, accepted for publication in PRD(Rapid Communication