Neurocognitive Deficits in Euthymic Bipolar Patients

Neurocognitive deficits detected in bipolar patients have a negative influence on clinical course and severity. We reviewed studies on neurocognitive deficits in euthymic bipolar subjects and their possible neuroanatomical correlates. We also examined studies suggesting deficits seen in euthymic patients may be endophenotypes of the disorder. Results of the studies in euthymic patients and their healthy relatives indicate that have cognitive dysfunctions especially of verbal memory, learning and executive domains, which were found to be related to prefrontal cortex and temporo-limbic circuitry. Longitudinal studies investigating heritability of cognitive impairment in bipolar disorder and its relation with brain connectivity and epigenetic mechanisms are needed

Structural and functional alterations in salivary gland chromosomes and enzyme activity of Chironomus riparius Mg. (Diptera, Chironomidae) from anthropogenically polluted sites in Bulgaria and Turkey

The effect of environment contaminants on genome instability and changes in enzyme activity (acetylcholinesterase (AChE), glutathione S-transferase activities (GST), etoxyresorufin O-deethylase (EROD) and metallothionein (MT)) of Chironomus riparius Mg. from Bulgarian and Turkish stations over two years (2009, 2010) as well as laboratory reared larvae were studied. Physicochemical analysis of the sediments from the field stations indicated the presence of heavy metal pollutants (Cr, Cu, Mn, Pb, and Cd) whose concentrations were higher than the reference data. Genome instability was determined by somatic structural and functional alterations of the polytene chromosomes. In the field sites of both countries somatic aberrations occurred at a significantly higher frequency (p < 0.001) compared with control and laboratory material. C. riparius in sediments with higher concentrations of trace metals (Derincay River, Turkey and Chaya River, Bulgaria), was found to possess a high spectrum of somatic chromosome rearrangements with a somatic index of 2.53 and 3.25 respectively. Changes in functional activity included decreased activity of the Balbiani rings (BRs) and nucleolar organizer (NOR). The observed chromosome alterations agree with the high degree of trace metal pollution and high activity of the studied enzymes. However, no correlation between single somatic chromosome rearrangements and concentrations of specific metal ions was defined. The data are discussed in the light of the wide variety of interactions of metals in nature. The results show that the genome response and biochemical markers are sensitive markers of toxicity and provide early warning indicators of contaminants in the environment. © 2012 Dipartimento di Biologia Evoluzionistica

Novel Exact Solutions of the Extended Shallow Water Wave and the Fokas Equations

In this study, a Sine-Gordon expansion method for obtaining novel exact solutions of extended shallow water wave equation and Fokas equation is presented. All of the equations which are under consideration consist of three or four variable. In this method, first of all, partial differential equations are reduced to ordinary differential equations by the help of variable change called as travelling wave transformation, then Sine Gordon expansion method allows us to obtain new exact solutions defined as in terms of hyperbolic trig functions of considered equations. The newly obtained results showed that the method is successful and applicable and can be extended to a wide class of nonlinear partial differential equations

Public Health Rep

12983486PMCnul

Novel Exact Solutions of the Extended Shallow Water Wave and the Fokas Equations

In this study, a Sine-Gordon expansion method for obtaining novel exact solutions of extended shallow water wave equation and Fokas equation is presented. All of the equations which are under consideration consist of three or four variable. In this method, first of all, partial differential equations are reduced to ordinary differential equations by the help of variable change called as travelling wave transformation, then Sine Gordon expansion method allows us to obtain new exact solutions defined as in terms of hyperbolic trig functions of considered equations. The newly obtained results showed that the method is successful and applicable and can be extended to a wide class of nonlinear partial differential equations

Prolonged anorexia nervosa associated with female-to-male gender dysphoria: A case report

Transsexual (TS) individuals seem to display an increased risk in having eating disorders. Several case reports describe TS individualswith anorexia nervosa (AN). In order to understand better the impact of gender dysphoria (GD) and hormonal/surgical treatments on the occurrence and course of eating disorders in TS patients long term follow-up studies are needed. We present here a 41-year-old female-to-male TS patient suffering from AN. History revealed that pathological eating habits could strongly be associated with her GD. Hormonal and surgical treatments resulted in substantial improvement in the given eating disorder. The impact of GD on the development and treatment of eating disorder is discussed in this report. (C) 2015 Elsevier Ltd. All rights reserved

Maksiller darlığı ve şiddetli çapraşıklığı olan hastanın cerrahi destekli üst çene genişletme tedavisi (SARME) : Olgu sunumu

The aim of this case report is to present an adult patient with a narrow maxilla and severe crowding treated with the help of surgically assisted maxillary expansion. A 17-year-old male patient referred to our clinic for the primary complaint of unaesthetic smile and severe upper anterior crowding. Extraoral examination revealed convex profile. Intraoral examination revealed narrow maxilla, posterior cross bite, V shaped upper arch form and severe crowding. The treatment was initiated with corticotomy operation for maxillary expansion. A tooth-borne acyrilic cap splint appliance with Hyrax screw was then fixed for distraction. Distraction protocol was started 7 days postoperatively by 2 turns a day (0.5 mm/ day). The distractor was left in place for an additional 3 months for stabilization and reossification after the required space had been achieved. Orthodontic fixed treatment started within 4 weeks after removal of the appliance. Computed tomography scans of the patient were performed to help the planning of the treatment 1 month before the orthodontic treatment. The data reconstructed using the Mimics software (Materialise, Leuven, Belgium) for surgical planning. Surgically assisted maxillary expansion is a successful treatment modality for adult patients requiring palatal expansion. The total treatment period was 24 months and the results were acceptable.Bu olgu sunumunun amacı dar üst çeneye ve şiddetli yer darlığına sahip yetişkinhastanın cerrahi destekli üst çene genişletilmesi yardımı ile tedavisinin sunulmasıdır.17 yaşında erkek hasta estetik olmayan gülümseme ve şiddetli üst ön çapraşıklık ilekliniğimize başvurdu. Ağız dışı incelemede konvex bir profil olduğu gözlendi. Ağıziçi incelemede dar bir maksilla, arka bölgede çapraz kapanış, V şekilli üst ark formuve şiddetli çapraşıklık gözlendi. Tedavi cerrahi operasyon ile başladı. Hyrax vidaiçeren diş destekli akrilik cap splint distraksiyon apareyi uygulandı. Distraksiyonprotokolüne operasyon sonrası 7 günlük bekleme sonrası günde 2 tur (0.5mm/gün) olacak şekilde başlandı. Gerekli yer elde edildikten sonra stabilizasyon ve yenikemik oluşumunun beklenmesi amacıyla distraktör operasyon sonrası 3 ay ağızdabırakıldı. Apareyin çıkartılmasını takiben 4 hafta sonra sabit tedaviye başlandı.Tedavi planlaması amacıyla hastanın bilgisayarlı tomografi görüntüleri tedaviden 1ay önce alındı. Analiz amaçlı, veriler Mimics (Materialise, Leuven, Belgium) yazılımıile yeniden oluşturuldu. Cerrahi destekli üst çene genişletme tedavisi palatalekspansiyon ihtiyacı olan yetişkin hastalarda başarılı bir tedavi yöntemidir. Toplamtedavi 24 ay sürmüştür ve kabul edilebilir sonuçlar elde edilmiştir