21 research outputs found
Post-European settlement impacts on erosion and land degradation: a case study using farm reservoir sedimentation in the Eastern Cape, South Africa
Sediment source tracing using mineral magnetism and gamma-emitting radionuclide signatures in farm reservoirs in the South African Karoo
TRANSITION METAL COMPLEXES OF 1,2-BIS(PHENYLSULFINYL) METHANE AND 1,2-BIS(PHENYLSULFINYL) ETHANE
Evidence that Cellulolysis by an Anaerobic Ruminal Fungus Is Catabolite Regulated by Glucose, Cellobiose, and Soluble Starch
CELPI: Trial protocol for a randomised controlled trial of a Carer End of Life Planning Intervention in people dying with dementia
Background: Dementia is a leading cause of death in developed nations. Despite an often distressing and symptom laden end of life, there are systematic barriers to accessing palliative care in older people dying of dementia. Evidence exists that 70% of people living with severe dementia attend an emergency department (ED) in their last year of life. The aim of this trial is to test whether a Carer End of Life Planning Intervention (CELPI), co-designed by consumers, clinicians and content specialists, improves access to end of life care for older people with severe dementia, using an ED visit as a catalyst for recognising unmet needs and specialist palliative care referral where indicated.
Methods: A randomised controlled trial (RCT) enrolling at six EDs across three states in Australia will be conducted, enrolling four hundred and forty dyads comprising a person with severe dementia agedââ„â65 years, and their primary carer.
Participants will be randomly allocated to CELPI or the control group. CELPI incorporates a structured carer needs assessment and referral to specialist palliative care services where indicated by patient symptom burden and needs assessment. The primary outcome measure is death of the person with dementia in the carer-nominated preferred location. Secondary outcomes include carer reported quality of life of the person dying of dementia, hospital bed day occupancy in the last 12 months of life, and carer stress. An economic evaluation from the perspective of a health funder will be conducted.
Discussion: CELPI seeks to support carers and provide optimal end of life care for the person dying of dementia. This trial will provide high level evidence as to the clinical and cost effectiveness of this intervention.
Trial registration: ACTRN12622000611729 registered 22/04/2022
CELPI: trial protocol for a randomised controlled trial of a Carer End of Life Planning Intervention in people dying with dementia.
BACKGROUND: Dementia is a leading cause of death in developed nations. Despite an often distressing and symptom laden end of life, there are systematic barriers to accessing palliative care in older people dying of dementia. Evidence exists that 70% of people living with severe dementia attend an emergency department (ED) in their last year of life. The aim of this trial is to test whether a Carer End of Life Planning Intervention (CELPI), co-designed by consumers, clinicians and content specialists, improves access to end of life care for older people with severe dementia, using an ED visit as a catalyst for recognising unmet needs and specialist palliative care referral where indicated. METHODS: A randomised controlled trial (RCT) enrolling at six EDs across three states in Australia will be conducted, enrolling four hundred and forty dyads comprising a person with severe dementia agedââ„â65Â years, and their primary carer. Participants will be randomly allocated to CELPI or the control group. CELPI incorporates a structured carer needs assessment and referral to specialist palliative care services where indicated by patient symptom burden and needs assessment. The primary outcome measure is death of the person with dementia in the carer-nominated preferred location. Secondary outcomes include carer reported quality of life of the person dying of dementia, hospital bed day occupancy in the last 12Â months of life, and carer stress. An economic evaluation from the perspective of a health funder will be conducted. DISCUSSION: CELPI seeks to support carers and provide optimal end of life care for the person dying of dementia. This trial will provide high level evidence as to the clinical and cost effectiveness of this intervention. TRIAL REGISTRATION: ACTRN12622000611729 registered 22/04/2022
Oxygen consumption and ammonia excretion of the searobin Prionotus punctatus (Scorpaeniformes, Triglidae) at two different temperatures
Routine oxygen consumption and ammonia excretion were measured at 20ÂșC and 25ÂșC in the searobin Prionotus punctatus collected in Ubatuba region (22Âș30'S), SP, Brazil, in western South Atlantic, to investigate energy expenditure and losses through metabolic processes. IndividuaIs ranging from 1.00g to 88.47g and from 1.79g to 56.50g were used in experiments at 20ÂșC and 25ÂșC, respectively. At 20ÂșC and 25ÂșC, the averages of weight-specific oxygen consumption for the weight class of 1.00 - 10.00g, common to both temperatures, were 162.46” 39.51 ”.10z/g/h and 200.47” 92.46 ”.10z/g/h, respectively; for the weight class of 50.01 - 60.00g these values were 112.30 ” 22.84 ”.10z/g/h and 114.60 ” 20.36 ”.10zlg/h. At 20ÂșC and 25ÂșC, the averages of weight-specific ammonia excretion for the weight class of 1.00 to 1O.00g were 1.03 ” 0.37 fJ.M/g/h and 1.21 ” 0.65 ”.M/g/h, respectively; for the weight class of 50.01 -60.00g these values were 0.68 ” 0.13 fJ.M/g/h and 0.60 ” 0.22 ”.M/g/h. The energy budget for the species was calculated at both temperatures using the experimental data and a model for marine teleosts proposed in the literature.<br>O consumo de oxigĂȘnio de rotina e a excreção de amĂŽnia de Prionotus punctatus coletados na regiĂŁo de Ubatuba (22Âș30'S), SP, Brasil, foram medidos a 20ÂșC e 25ÂșC, para avaliar os gastos e perdas de energia com os processos metabĂłlicos. Foram utilizados indivĂduos variando de 1,00g a 88,47g e de 1,79g a 56,50g, em experimentos a 20ÂșC e 25ÂșC, respectivamente. As mĂ©dias de consumo especĂfico de oxigĂȘnio a 20ÂșC e 25ÂșC para a classe de peso de 1,00 - 10,00g, comum a ambas as temperaturas, foram 162,46” 39,51 ”.10z/g/h e 200,47 ” 92,46 ”.10z/g/h, respectivamente; para a classe de peso de 50,01 - 60,00g esses valores foram 112,30 ” 22,84 ”.10z/g/h e 114,60 ” 20,36 ”.10z/g/h. A 20ÂșC e 25ÂșC, as mĂ©dias de excreção especĂfica de amĂŽnia para a classe de peso de 1,00 a 10,00g foram 1,03 ” 0,37 e 1,21 ” 0,65 ”.M/g/h, respectivamente; para a classe de peso de 50,01 - 60,00g esses valores foram 0,68 ” 0,13 ”.M/g/h e 0,60 ” 0,22 ”.M/g/h. O orçamento energĂ©tico para a espĂ©cie foi calculado para cada temperatura utilizando-se os da.dos experimentais e modelo proposto na literatura