End-to-End Beam Dynamics for CERN LINAC4

LINAC 4 is a normal conducting H- linac which aims to intensify the proton flux available for the CERN accelerator complex. This injector is designed to accelerate a 65 mA beam of H- ions up to 160 MeV for injection into the CERN Proton Synchrotron Booster. The acceleration is done in three stages : up to 3 MeV with a Radio Frequency Quadrupole (the IPHI RFQ) operating at 352 MHz, then continued to 90 MeV with drift-tube structures at 352 MHz (conventional Alvarez and Cell Coupled Drift Tube Linac) and, finally with a Side Coupled Linac at 704 MHz. The accelerator is completed by a chopper line at 3 MeV and a transport and matching line to the PS booster. After the overall layout was determined based on general consideration of beam dynamics and RF, a global optimisation based on end-to-end simulation has refined some design choices. The results and lessons learned from the end-to-end simulations are reported in this paper

Beam dynamics studies in SPIRAL II LINAC

ACCInternational audienceThe proposed LINAG driver for the SPIRAL 2 project aims to accelerate a 5-mA D+ beam up to 20 A.MeV and 1-mA beam for q/A=1/3 up to 14.5 A.MeV. It is acontinuous wave regime (cw), designed for maximum efficiency in the transmission of intense beams. It consists of an injector (two ECR sources + a Radio Frequency Quadrupole) followed by a superconducting section based on an array of independently phased cavities. This paper presents beams dynamics studies associated to the LINAG driver. End-to-end simulations (low-energy beam lines, RFQ, medium-energy beam line, SC linac) are shown

The SPL (II) at CERN, a Superconducting 3.5 GeV H- Linac

A revision of the physics needs and recent progress in the technology of superconducting (SC) RF cavities have triggered major changes in the design of a SC H-linac at CERN. With up to 5MW beam power, the SPL can be the proton driver for a next generation ISOL-type radioactive beam facility (âEURISOLâ) and/or supply protons to a neutrino () facility (conventional superbeam + beta-beam or -factory). Furthermore the SPL can replace Linac2 and the PS booster (PSB), improving significantly the beam performance in terms of brightness, intensity, and reliability for the benefit of all proton users at CERN, including LHC and its luminosity upgrade. Compared with the first conceptual design, the beam energy is almost doubled (3.5GeV instead of 2.2 GeV) while the length is reduced by 40%. At a repetition rate of 50 Hz, the linac reuses decommissioned 352.2MHz RF equipment from LEP in the low-energy part. Beyond 90MeV the RF frequency is doubled, and from 180MeV onwards high-gradient SC bulkniobium cavities accelerate the beam to its final energy of 3.5GeV. This paper presents the overall design approach, together with the technical progress since the first conceptual design in 2000

Conceptual design of the SPL II: A high-power superconducting H−H^- linac at CERN

An analysis of the revised physics needs and recent progress in the technology of superconducting RF cavities have led to major changes in the speci cation and in the design for a Superconducting Proton Linac (SPL) at CERN. Compared with the rst conceptual design report (CERN 2000012) the beam energy is almost doubled (3.5 GeV instead of 2.2 GeV), while the length of the linac is reduced by 40% and the repetition rate is reduced to 50 Hz. The basic beam power is at a level of 45MW and the approach chosen offers enough margins for upgrades. With this high beam power, the SPL can be the proton driver for an ISOL-type radioactive ion beam facility of the next generation (`EURISOL'), and for a neutrino facility based on superbeam C beta-beam or on muon decay in a storage ring (`neutrino factory'). The SPL can also replace the Linac2 and PS Booster in the low-energy part of the CERN proton accelerator complex, improving signi cantly the beam performance in terms of brightness and intensity for the bene t of all users including the LHC and its luminosity upgrade. Decommissioned LEP klystrons and RF equipment are used to provide RF power at a frequency of 352.2 MHz in the lowenergy part of the accelerator. Beyond 90 MeV, the RF frequency is doubled to take advantage of more compact normal-conducting accelerating structures up to an energy of 180 MeV. From there, state-ofthe- art, high-gradient, bulk-niobium superconducting cavities accelerate the beam up to its nal energy of 3.5 GeV. The overall design approach is presented, together with the progress that has been achieved since the publication of the rst conceptual design report

NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment

Spontaneous CD4+ T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4+ T cells in EOC patients with spontaneous immune responses to the antigen are prevalently TH1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer+ cells ex vivo, at an average frequency of 1∶25000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer+ cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25+FOXP3+Treg. Thus, spontaneous CD4+ T-cell responses to ESO in cancer patients are prevalently of TH1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines

Space charge compensation in low energy proton beams

High power accelerators are being studied for several projects including accelerator driven neutron or neutrino sources. The low energy part of these facilities has to be carefully optimized to match the beam requirements of the higher energy parts. In this low energy part, the space charge self force, induced by a high intensity beam, has to be carefully managed. This nonlinear force can generate a high irreversible emittance growth of the beam. To reduce space charge effects, neutralization of the beam charge can be done by capturing some particles of the ionised residual gas in the vacuum chamber. This space charge compensation (SCC) regime complicates the dynamic study. Modelling the beam behaviour in such regime would be a significant contribution to the development of high intensity accelerators. Numerical and experimental study of SCC is in progress on the Saclay High Intensity Proton Injector. Experimental measurements and 2D/3D simulations of proton beam SCC will be presented

Genetic variability and stability of grain magnesium, zinc and iron concentrations in bread wheat

Four trials were conducted to study the grain magnesium (Mg), zinc (Zn) and iron (Fe) concentrations in bread wheat (Triticum aestivum L.). These trials used different sources of genotypes, including old French landraces, a worldwide germplasm collection and elite breeding lines or modem cultivars, grown in different environments. Mg concentration ranged from 600 to 1400 ppm in modem material, and reached 1890 ppm in some exotic genotypes. There was a negative correlation between grain yield and Mg concentration, but despite this dilution effect enough variability remains useful for selection purposes. Analysis of variance showed high genotype effects and Spearman rank correlations indicated moderate genotype by environment (G x E) interactions, so breeding for high Mg concentration can reasonably be envisaged. Zn concentration generally ranged from 15 to 35 ppm, but increased to 43 ppm in some genetic resources. Variation in Zn was also partly explained by a dilution effect. There was a significant effect of genotype, but also high G x E interactions, which would make direct selection more difficult than for Mg. However, as Zn and Mg concentrations appeared to be positively correlated, Zn concentration should respond favorably to selection for high Mg concentration. Fe concentration ranged from 20 to 60 ppm, and reached 88 ppm in non-adapted material. There were no significant genotype effects, very high G x E interactions, and the trait was poorly correlated to other mineral concentrations. Breeding for high Fe concentration will thus probably prove illusory