137 research outputs found
Innovation: A selection from the Bodleian’s Special Collections for the Vice Chancellor's Circle
Inventiveness in the sciences and humanities as shown in manuscripts, rare books, and archives in the Bodleian's Special Collections
Silicon carbide and other films and method of deposition
A method of depositing a ceramic film, particularly a silicon carbide film, on a substrate is disclosed in which the residual stress, residual stress gradient, and resistivity are controlled. Also disclosed are substrates having a deposited film with these controlled properties and devices, particularly MEMS and NEMS devices, having substrates with films having these properties
Composition Comprising Silicon Carbide
A method of depositing a ceramic film, particularly a silicon carbide film, on a substrate is disclosed in which the residual stress, residual stress gradient, and resistivity are controlled. Also disclosed are substrates having a deposited film with these controlled properties and devices, particularly MEMS and NEMS devices, having substrates with films having these properties
Repurposeable Learning Objects Based on Teaching and Learning Styles
Multimedia learning objects are an essential
component of high quality, technology-mediated
instruction. Learning objects allow the student to use
the content learned in a particular part of a course and;
1. demonstrate mastery of the content, 2. apply that
knowledge to solving a problem, and 3. use the
content in a critical thinking exercise that both
demonstrates mastery and allows the student to place
the content within the context of the larger topic of the
course. The difficulty associated with the use of
learning objects on a broad scale is that they require
programming skills most professors and instructors do
not possess. Learning objects also tend to be custom
productions and are defined in terms of the
programming and code terminology, further limiting
the professor’s ability to understand how they are
created. Learning objects defined in terms of styles of
learning and teaching allow professors and instructors
to develop a deeper understanding of the learning
objects and the design process.
A set of learning objects has been created that are
designed for some of the important styles of learning
and teaching. They include; visual learning, writing
skills, critical thinking, time-revealed scenarios, case
studies and empirical observation. The learning
objects are designed and described in terms that the
average instructor can readily understand , redesign
and incorporate into their own courses. They are also
designed in such a way that they can readily be
repurposed for new applications in other courses and
subject areas, with little or no additional
programming. (Authors' abstract
Optimizing the pedagogical impact of Learning Modality-based Learning Object Using Artificial Intelligence
Fabrication on the microscale : a two-photon polymerized device for oocyte microinjection
Open Access funding enabled and organized by CAUL and its Member Institutions. KRD is supported by a Mid-Career Fellowship from the Hospital Research Foundation (C-MCF-58–2019). KD acknowledges funding from the UK Engineering and Physical Sciences Research Council (grant EP/P030017/1). This study was funded by the Australian Research Council (ARC) Centre of Excellence for Nanoscale BioPhotonics (CE140100003).Purpose Intracytoplasmic sperm injection (ICSI) addresses male sub-fertility by injecting a spermatozoon into the oocyte. This challenging procedure requires the use of dual micromanipulators, with success influenced by inter-operator expertise. We hypothesized that minimizing oocyte handling during ICSI will simplify the procedure. To address this, we designed and fabricated a micrometer scale device that houses the oocyte and requires only one micromanipulator for microinjection. Methods The device consisted of 2 components, each of sub-cubic millimeter volume: a Pod and a Garage. These were fabricated using 2-photon polymerization. Toxicity was evaluated by culturing single-mouse presumptive zygotes (PZs) to the blastocyst stage within a Pod, with several Pods (and embryos) docked in a Garage. The development was compared to standard culture. The level of DNA damage/repair in resultant blastocysts was quantified (γH2A.X immunohistochemistry). To demonstrate the capability to carry out ICSI within the device, PZs were microinjected with 4-μm fluorescent microspheres and cultured to the blastocyst stage. Finally, the device was assessed for oocyte traceability and high-throughput microinjection capabilities and compared to standard microinjection practice using key parameters (pipette setup, holding then injecting oocytes). Results Compared to standard culture, embryo culture within Pods and a Garage showed no differences in development to the blastocyst stage or levels of DNA damage in resultant blastocysts. Furthermore, microinjection within our device removes the need for a holding pipette, improves traceability, and facilitates high-throughput microinjection. Conclusion This novel device could improve embryo production following ICSI by simplifying the procedure and thus decreasing inter-operator variability.Publisher PDFPeer reviewe
Technology is too important to leave to technologists
The TALON/nPower learning object suite, developed by Arjuna Multimedia, is a set of 39 repurposeable learning object templates based on styles of teaching and learning that are designed to allow instructors and designers to create substantive learning objects without changing any of the source code. The instructor or designer can use the templates to design a new learning object without writing or changing any source code. The templates are simple enough that instructors with little or no programming experience can create their own learning objects. This paper examines the experiences of two professors’ use of the templates to create interactive exercises for their courses
A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data.
Illumina BeadArrays are among the most popular and reliable platforms for gene expression profiling. However, little external scrutiny has been given to the design, selection and annotation of BeadArray probes, which is a fundamental issue in data quality and interpretation. Here we present a pipeline for the complete genomic and transcriptomic re-annotation of Illumina probe sequences, also applicable to other platforms, with its output available through a Web interface and incorporated into Bioconductor packages. We have identified several problems with the design of individual probes and we show the benefits of probe re-annotation on the analysis of BeadArray gene expression data sets. We discuss the importance of aspects such as probe coverage of individual transcripts, alternative messenger RNA splicing, single-nucleotide polymorphisms, repeat sequences, RNA degradation biases and probes targeting genomic regions with no known transcription. We conclude that many of the Illumina probes have unreliable original annotation and that our re-annotation allows analyses to focus on the good quality probes, which form the majority, and also to expand the scope of biological information that can be extracted
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