CANONICAL CORRELATION ANALYSIS OF SELECTED DEMOGRAPHIC AND HEALTH PERSONNEL VARIABLES

Labor and Human Capital,

CAPACITY DECISIONS FOR AN EMERGENCY SERVICE

Public Economics,

Forage variety trials in New Hampshire 1951-1956, Station Bulletin, no.439

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

Widely-tunable mid-infrared ring cavity pump-enhanced OPO and application in photo-thermal interferometric trace ethane detection

Funding: Innovate UK (133076); Engineering and Physical Sciences Research Council (EP//L01596X/1, EP/M01326X/1, EP/M024385/1); European Research Council (ERC-2018-STG 803665).The development of a broadly and accurately tunable single-frequency mid-infrared laser source and its application to a sensitive laser absorption detection method are described. Photo-thermal interferometric spectroscopy is employed as a phase-sensitive method to detect the minute refractive index change caused by the heating of a gas under laser radiation. A separate probe beam allows for the spectrally-interesting mid-infrared region to be examined whilst utilizing low cost, high detectivity photodetectors in the visible/near-infrared region. We also describe the implementation of a Sagnac interferometer to minimize the effects of environmental perturbation and provide inherent passive stability. A continuous-wave ring-cavity pump-enhanced OPO has been developed to provide excitation light from 3–4 µm at 140 mW with the ability to mode-hop tune continuously over 90 cm−1 in 0.07 cm−1 steps. Complementary use of both detection apparatus and excitation source has allowed for presence of ethane to be detected down to 200 parts per billion.developed to provide excitation light from 3–4 µm at 140 mW with the ability to mode-hop tune continuously over 90 cm−1 in 0.07 cm−1 steps. Complementary use of both detection apparatus and excitation source has allowed for presence of ethane to be detected down to 200 parts per billion.Publisher PDFPeer reviewe

Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures

BACKGROUND: Genetic maps based on single-nucleotide polymorphisms (SNP) are increasingly being used as an alternative to microsatellite maps. This study compares linkage results for both types of maps for a neurophysiology phenotype and for an alcohol dependence phenotype. Our analysis used two SNP maps on the Illumina and Affymetrix platforms. We also considered the effect of high linkage disequilibrium (LD) in regions near the linkage peaks by analysing a "sparse" SNP map obtained by dropping some markers in high LD with other markers in those regions. RESULTS: The neurophysiology phenotype at the main linkage peak near 130 MB gave LOD scores of 2.76, 2.53, 3.22, and 2.68 for the microsatellite, Affymetrix, Illumina, and Illumina-sparse maps, respectively. The alcohol dependence phenotype at the main linkage peak near 101 MB gave LOD scores of 3.09, 3.69, 4.08, and 4.11 for the microsatellite, Affymetrix, Illumina, and Illumina-sparse maps, respectively. CONCLUSION: The linkage results were stronger overall for SNPs than for microsatellites for both phenotypes. However, LOD scores may be artificially elevated in regions of high LD. Our analysis indicates that appropriately thinning a SNP map in regions of high LD should give more accurate LOD scores. These results suggest that SNPs can be an efficient substitute for microsatellites for linkage analysis of both quantitative and qualitative phenotypes

Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps

We used the LOKI software to generate multipoint identity-by-descent matrices for a microsatellite map (with 31 markers) and two single-nucleotide polymorphism (SNP) maps to examine information content across chromosome 7 in the Collaborative Study on the Genetics of Alcoholism dataset. Despite the lower information provided by a single SNP, SNP maps overall had higher and more uniform information content across the chromosome. The Affymetrix map (578 SNPs) and the Illumina map (271 SNPs) provided almost identical information. However, increased information has a computational cost: SNP maps require 100 times as many iterations as microsatellites to produce stable estimates

The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure

Accurately resolving population structure in a sample is important for both linkage and association studies. In this study we investigated the power of single-nucleotide polymorphisms (SNPs) in detecting population structure in a sample of 286 unrelated individuals. We varied the number of SNPs to determine how many are required to approach the degree of resolution obtained with the Collaborative Study on the Genetics of Alcoholism (COGA) short tandem repeat polymorphisms (STRPs). In addition, we selected SNPs with varying minor allele frequencies (MAFs) to determine whether low or high frequency SNPs are more efficient in resolving population structure. We conclude that a set of at least 100 evenly spaced SNPs with MAFs of 40–50% is required to resolve population structure in this dataset. If SNPs with lower MAFs are used, then more than 250 SNPs may be required to obtain reliable results

A novel framework for distress detection through an automated speech processing system

Based on our ongoing work, this work in progress project aims to develop an automated system to detect distress in people to enable early referral for interventions to target anxiety and depression, to mitigate suicidal ideation and to improve adherence to treatment. The project will utilize either use existing voice data to assess people into various scales of distress, or will collect voice data as per existing standards of distress measurement, to develop basic computing algorithms required to detect various attributes associated with distress, detected through a person’s voice in a telephone call to a helpline. This will be then matched with the already available psychological assessment instruments such as the Distress Thermometer for these persons. In order to trigger interventions, organizational contexts are essential as interventions rely on the type of distress. Therefore, the model will be tested on various organizational settings such as the Police, Emergency and Health along with the Distress detection instruments normally used in a psychological assessment for accuracy and validation. The outcome of the project will culminate in a fully automated integrated system, and will save significant resources to organizations. The translation of the project will be realized in step-change improvements to quality of life within the gamut of public policy