An evolutionary perspective on zinc uptake by human fungal pathogens

DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher PD

A tale of two yeasts : Saccharomyces cerevisiae as a therapeutic against candidiasis

Funding DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z), the MRC and University of Aberdeen (MR/N006364/1).Peer reviewedPublisher PD

Essential metals at the host-pathogen interface : nutritional immunity and micronutrient assimilation by human fungal pathogens

AC and DW are supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher PD

From attachment to damage : defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells

Peer reviewedPublisher PD

Cyclic AMP pathway activation and extracellular zinc induce rapid intracellular zinc mobilization in Candida albicans

LK was supported by Innovation Fund Denmark, DK (4019-00019B). Pcovery ApS received funding from Wellcome Trust, Research Councils, UK (100480/Z/12), Novo Seeds, DK and Boehringer Ingelheim Venture Fund, D. DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), the Medical Research Council and University of Aberdeen (MR/N006364/1) and received support from a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). The funders had no part in study design, data collection and interpretation, or the decision to submit the work for publication.Peer reviewedPublisher PD

An Application of Multi-band Forced Photometry to One Square Degree of SERVS: Accurate Photometric Redshifts and Implications for Future Science

We apply The Tractor image modeling code to improve upon existing multi-band photometry for the Spitzer Extragalactic Representative Volume Survey (SERVS). SERVS consists of post-cryogenic Spitzer observations at 3.6 and 4.5 micron over five well-studied deep fields spanning 18 square degrees. In concert with data from ground-based near-infrared (NIR) and optical surveys, SERVS aims to provide a census of the properties of massive galaxies out to z ~ 5. To accomplish this, we are using The Tractor to perform "forced photometry." This technique employs prior measurements of source positions and surface brightness profiles from a high-resolution fiducial band from the VISTA Deep Extragalactic Observations (VIDEO) survey to model and fit the fluxes at lower-resolution bands. We discuss our implementation of The Tractor over a square degree test region within the XMM-LSS field with deep imaging in 12 NIR/optical bands. Our new multi-band source catalogs offer a number of advantages over traditional position-matched catalogs, including 1) consistent source cross-identification between bands, 2) de-blending of sources that are clearly resolved in the fiducial band but blended in the lower-resolution SERVS data, 3) a higher source detection fraction in each band, 4) a larger number of candidate galaxies in the redshift range 5 < z < 6, and 5) a statistically significant improvement in the photometric redshift accuracy as evidenced by the significant decrease in the fraction of outliers compared to spectroscopic redshifts. Thus, forced photometry using The Tractor offers a means of improving the accuracy of multi-band extragalactic surveys designed for galaxy evolution studies. We will extend our application of this technique to the full SERVS footprint in the future.Comment: accepted to ApJ, 22 pages, 12 figure

Roadmap for Real World Internet applications

This paper emphasises the socioeconomic background required to design the Future Internet in order that its services will be accepted by its users and that the economic value latent in the technology is realised. It contains an innovative outlook on sensing aspects of the Future Internet and describes a scenario-based design approach that is feasible to roadmap the dynamic deployment of Real World Internet applications. A multifaceted socioeconomic assessment leads to recommendations for the technology deployment and key features of the Future Internet that will globally integrate technologies like Wireless Sensor and Actuator Networks and Networked Embedded Devices.Real World Internet ; Future Internet ; Scenario-based Design ; Socioeconomics ; Business Models ; Requirements

On board sampling of the rockfish and lingcod commerical passenger fishing vessel industry in northern and central California, May 1987 to December 1991

From May 1987 to June 1990 and from August to December 1991 Fishery Technicians sampled catches on board 690 Commercial Passenger Fishing Vessel (CPFV) trips targeting rockfish and lingcod from the general port areas of Fort Bragg, Bodega Bay, San Francisco, Monterey, and Morro Bay. Data are presented for species composition by port area, year, and month, for catch-per-unit-effort, mean length, and length frequency of lingcod and the 18 most frequently observed rockfish species, and for trends in fishing effort related to fishing time, depth, and distance from port. Total catch estimates are presented based on unadjusted logbook records, logbook records adjusted by sampling data and compliance rates, and effort data from a marine recreational fishing statistics survey. Average catch of kept fish per angler day was 11.8 and average catch of kept fish per angler hour was 3.7. A trend of an increasing frequency of trips to deep (>40 fm) locations was observed in the Bodega Bay, San Francisco, and Monterey areas from 1988 to 1990-91. No trend was evident relative to trip frequency and distance from port. A total of 74 species was observed caught during the study. Rockfishes comprised 88.5% to 97.9% by number of the observed catch by port area. The five most frequently observed species were chilipepper, blue, yellowtail, and widow rockfishes, and bocaccio, with lingcod ranking seventh. In general, mean length and catch-per-angler-hour of sport fishes caught by CPFV anglers varied considerably and did not show steady declines during the study period. However, port-specific areas of major concern were identified for chilipepper, lingcod, and black rockfish, and to a lesser extent brown, canary, vermilion, yelloweye, olive, and widow rockfish. These areas of concern included steadily declining catch rate, steadily declining mean length, and a high percentage of sexually immature fish in the sampled-catch. Recent sampling of the commercial hook-and-line fishery in northern and central California indicated that most species of rockfishes taken by CPFV anglers are also harvested commercially. (261pp.