2,863 research outputs found

    An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance

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    Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence genes. At abnormal levels, miRNAs can either gain ability to silence tumour suppressor genes or else lose ability to silence oncogenes. miRNAs can also affect pathways that are involved in drug metabolism, such as drug efflux pumps, resulting in a resistant phenotype. The scope of this review is to provide an introspective analysis on the specific niches of breast carcinoma and neuroblastoma research.peer-reviewe

    A Comparative Analysis of Operation Bluestone: A Specialist Rape Investigation Unit - Summary Report

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    The file attached to this record is the author's final version.This summary report sets out the findings of an evaluation into the performance of a specialist rape investigation unit and a non-specialist comparator

    Strengthening Deafness and Education International's scope

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    Arts in Mind: A Multidisciplinary Approach to Museum Programs for Persons Living with Young-Onset and Early-Stage Alzheimer’s Disease

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    This paper reflects on Arts in Mind, an ongoing museum-based program for those with Young-onset Alzheimer’s or in the early stages of memory loss. Co- developed in 2019 by the authors, an art therapist with experience in Alzheimer’s clinical trials research and two museum educators. Arts in Mind is a monthly program that invites people living with Young-onset Alzheimer’s and their care partners to look at and make art together. Arts in Mind responds to a previously unmet need for programming specifically designed for the Young-onset Alzheimer’s population and individuals in early stages of the disease. Sessions are anchored in the art encounter, accessible, responsive, and experiential. Additionally, the program a site of mentorship for the next generation of art therapists, museum educators and medical professionals. This paper offers a replicable and sustainable partnership model for museum and art therapy- based memory loss programs for an often overlooked population

    Predicting Invasion Rates for Phragmites australis

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    In wetlands of Utah and southern Idaho as well as estuaries of the east coast, the ten-foot tall invasive grass Phragmites australis can be found near waterways, where it outcompetes native plants and degrades wildlife habitat. Phragmites australis is an obligate out-crossing plant that can spread sexually through seed disper- sal, or asexually via stolons and rhi- zomes (Kettenring and Mock 2012). Small patches are usually a single genetic individual, spreading vegetatively (and slowly) via runners; when patches become genetically diverse viable seeds are produced and invasion rates can be increase by an order of magnitude (Kettenring et al. 2011

    EVALUATION OF THE 2006/7 AGRICULTURAL INPUT SUBSIDY PROGRAMME, MALAWI. FINAL REPORT

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    This report evaluates the 2006/7 Malawi Government Agricultural Input Subsidy Programme (AISP). The main objective of the evaluation is to assess the impact and implementation of the AISP in order to provide lessons for future interventions in growth and social protection. The evaluation combined qualitative and quantitative methods of data collection and analysis. Quantitative data were collected through a national survey in 2007 of 2,491 households who were previously interviewed in the 2004/05 Integrated Household Survey, a survey of retail shops selling inputs in six districts and data on stocks and sales from manufacturers, large-scale importers and dealers of fertilizers and seeds. The quantitative data was triangulated by qualitative data from focus group discussions with smallholder farmers in 12 districts, and key informant interviews with government staff, input distributors and beneficiary and non-beneficiary households. The analysis is based on descriptive statistics, econometric modelling and livelihood and rural economy modelling. An Interim Report in March 2007 provides fuller details of the implementation of the programme.Agribusiness, Agricultural and Food Policy, Community/Rural/Urban Development, Food Consumption/Nutrition/Food Safety, Food Security and Poverty, Productivity Analysis,
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