Therapeutic properties and phenantrens compounds of Tamus communis

From ancient in folk medicine the plants were used with lots of trust and efficiency. In time, people learn how to cultivate, to sample, and preserve different anatomical parts of the plant for medical purposes. Thus, also Tamus communis became an interesting plant, being used in different pharmaceutical formulations to treat different medical conditions. The extracts of root of T. communis is just one phyto-pharmaceutical form that demonstrated to have antiinflammatory and antioxidant effect. Different anatomical parts of T. communis, various extraction methods using various solvents, were used in experimental researches to test the efficiency as cytotoxic and antiviral activities, antioxidant activity, anti-inflammatory and analgesic activity. Extracts of T. communis are used for preparation of poultice, ointments, and also for infusions, tincture preparation with very good pharmacologic activity. This paper only made a very succinct presentation of the possibilities to used Tamus communis as a main ingredient of different natural pharmacological preparation with applicability in human and veterinary medicine

Geomorphosites and geotourism in Bucharest city center (Romania)

The present paper aims at inventorying the geomophosites in Bucharest as well as introducing geotouristic itineraries that take into account the long-time developed high value cultural heritage of the area. The process included several stages: studying Bucharest’s relief and cultural- historical elements with tourist value from existing bibliography, cartographic methods (aerial photos and different editions of topographic maps), as well as the information gathered from field investigations; identifying and inventorying geomorphosites, assessing the population’s opinion about geoheritage (geomorphosites) and its capitalization in tourism activities, 100 questionnaires were applied; creating geotouristic itineraries and later promoting them. The most valuable and representative geomorphosites identified are: on Colentina Valley (the Plumbuita, Ostrov, Dobroeşti and Pantelimon hills) (aren’t located in the study area), on Dâmboviței Valley (Cotroceni, Șerban Vodă, Mitropoliei, Spirii, Filaret and Arsenal hills, Țăcăliei, Procopoaiei, University terraces, Dâmbovița Meadow). The authors suggest two geotouristic itineraries that emphasize the relationship between the scientific, cultural, and historic elements as well as the human-nature report within the urban area

MISAME

Recording of Iancu Dumitrescu's Implosive eternity. This is a work for electronics that the composer created as a result of meticulous studies in the field of micro-intervals, harmonic spectra, and sonic distortions. The composer wanted to use those phenomena as their own unique "sound objects". The composer describes this work as being continually changing and colorful

MISAME

Recording of Iancu Dumitrescu's Bolids & Contemplation. This is a work for electronics that the composer considers a numerical composition, starting from some proportions and numerical series, which gives it structure. The rhythmic aspect of the instruments' performing must interact with the numerical relations in the pre-registered computer-assisted musical part

L’instabilité de l’écoulement dans les chambres d’aspiration

Flow instability in pumping plant suction chambers. Instability due to certain secondary effects such as surface or bottom eddies or a general free surface oscillation. Similitary criterion. Results of laboratory research. Recommended methods of ensuring stable plant operation.L'ouvrage traite l'instabilité de l'écoulement dans les chambres d'aspiration des stations de pompage, instabilité due à l'apparition de certains phénomènes secondaires tels que les tourbillons de surface, tourbillons de fond ou bien l'oscillation générale de la surface libre. On établit un critérium de similitude, nécessaire au modelage des phénomènes hydrauliques dans les chambres d'aspiration, et on fait un exposé des résultats de caractère général, obtenus à la suite des recherches effectuées au laboratoire. Finalement, on fait des recommandations d'ordre pratique ayant le but d'assurer la stabilité de l'écoulement dans le cas de l'exploitation d'aménagements pareils.Dumitrescu D., Iamandi C., Iancu C. L’instabilité de l’écoulement dans les chambres d’aspiration. In: Les instabilités en hydraulique et en mécanique des fluides. Compte rendu des huitièmes journées de l'hydraulique; Lille, 8-10 juin 1964. Tome 1, 1965

TRPV1 properties in thoracic dorsal root ganglia neurons are modulated by intraperitoneal capsaicin administration in the late phase of Type-1 autoimmune diabetes.

Pharmacological therapies in type 1 diabetes for efficient control of glycemia and changes in pain alterations due to diabetic neuropathy are a continuous challenge. Transient receptor potential vanilloid type 1 (TRPV1) from dorsal root ganglia (DRG) neurons is one of the main pharmacological targets in diabetes, and its ligand capsaicin can be a promising compound for blood-glucose control. Our goal is to elucidate the effect of intraperitoneal (i.p.) capsaicin administration in type 1 diabetic mice against TRPV1 receptors from pancreatic DRG primary afferent neurons. A TCR+/ 12/Ins-HA+/ 12 diabetic mice (dTg) was used, and patch-clamp and immunofluorescence microscopy measurements have been performed on thoracic T9\u2013T12 DRG neurons. Capsaicin (800 \u3bcg/kg, i.p. three successive days) administration in the late-phase diabetes reduces blood-glucose levels, partly reverses the TRPV1 current density and recovery time constant, without any effect on TRPV1 expression general pattern, in dTg mice. A TRPV1 hypoalgesia profile was observed in late-phase diabetes, which was partly reversed to normoalgesic profile upon capsaicin i.p. administration. According to the soma dimensions of the thoracic DRG neurons, a detailed analysis of the TRPV1 expression upon capsaicin i.p. treatment was done, and the proportion of large A-fiber neurons expressing TRPV1 increased in dTg capsaicin-treated mice. In conclusion, the benefits of low-dose capsaicin intraperitoneal treatment in late-phase type-1 diabetes should be further exploited

Advanced type 1 diabetes is associated with ASIC alterations in mouse lower thoracic dorsal root ganglia neurons.

Acid-sensing ion channels (ASICs) from dorsal root ganglia (DRG) neurons are proton sensors during ischemia and inflammation. Little is known about their role in type 1 diabetes (T1D). Our study was focused on ASICs alterations determined by advanced T1D status. Primary neuronal cultures were obtained from lower (T9-T12) thoracic DRG neurons from Balb/c and TCR-HA(+/-)/Ins-HA(+/-) diabetic male mice (16\ua0weeks of age). Patch-clamp recordings indicate a change in the number of small DRG neurons presenting different ASIC-type currents. Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation. Immunofluorescence indicates opposite regulation of different ASIC transcripts while qRT-PCR shows that ASIC mRNA ranking (ASIC2\ua0>\ua0ASIC1\ua0>\ua0ASIC3) remains unaltered. In conclusion, our study has identified biochemical and biophysical ASIC changes in lower thoracic DRG neurons due to advanced T1D. As hypoalgesia is present in advanced T1D, ASICs alterations might be the cause or the consequence of diabetic insensate neuropathy

Histomorphometric Features of Deltoid Muscle (Musculus Deltoideus) in the Mouflon (Ovis ammon musimon Pal.) and Domestic Sheep

The aim of this study was to determine histomorphometry of the skeletal muscle at rams from the Tigaie breed and males mouflon (Ovis ammon musimon Pal.) knowing that, in addition to a variety of factors, both the fiber thickness and muscle fascicles influence of meat quality. The study was conducted on the deltoid muscle fragments taken from five individuals of the each species. The muscle samples were processed according to the method of embedded in paraffin, sectioned to a thickness of 5 µm and stained with Mallory's trichrome method. From the histomorphometric analysis resulted that in mouflon, the average area of muscle fascicles is larger, as compared with the ram (p <0.05), the ratio between the fascicles muscle area and the interfascicular connective tissue being 2.939:1 to mouflon and 1,624:1 to ram. Also, at mouflon the muscle fibers are thicker, the area and perimeter  registering an average value of 486.60 μm2, respectively 82.83 μm while in the ram, the area of the muscle fibers is 281.56 μm2 and the perimeter of 62.92 μm (p <0.001). The amount of interfibrillar connective tissue is higher in the ram (p <0.05) and the ratio between the muscular fibers area and interfibrillar connective tissue area was 1.649:1 in mouflon and 1.451:1 at ram (p<0.05)