Addendum: "The Dynamics of M15: Observations of the Velocity Dispersion Profile and Fokker-Planck Models" (ApJ, 481, 267 [1997])

It has recently come to our attention that there are axis scale errors in three of the figures of Dull et al. (1997, hereafter D97). D97 presented Fokker-Planck models for the collapsed-core globular cluster M15 that include a dense, centrally concentrated population of neutron stars and massive white dwarfs, but do not include a central black hole. In this Addendum, we present corrected versions of Figures 9, 10, and 12, and an expanded version of Figure 6. This latter figure, which shows the full run of the velocity dispersion profile, indicates that the D97 model predictions are in good agreement with the moderately rising HST-STIS velocity dispersion profile for M15 reported by Gerssen et al. (2002, astro-ph/0209315). Thus, a central black hole is not required to fit the new STIS velocity measurements, provided that there is a sufficient population of neutron stars and massive white dwarfs. This conclusion is consistent with the findings of Gerssen et al. (2002, astro-ph/0210158), based on a reapplication of their Jeans equation analysis using the corrected mass-to-light profile (Figure 12) for the D97 models.Comment: 4 pages, 4 figures, submitted to Ap

Antibody persistence 22 months after vaccination of adolescents with the Novartis investigational meningococcal ACWY-CRM197 conjugate vaccine or Menactra®

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Evidence for antibody as a protective correlate for COVID-19 vaccines

A correlate of protection (CoP) is urgently needed to expedite development of additional COVID-19 vaccines to meet unprecedented global demand. To assess whether antibody titers may reasonably predict efficacy and serve as the basis of a CoP, we evaluated the relationship between efficacy and in vitro neutralizing and binding antibodies of 7 vaccines for which sufficient data have been generated. Once calibrated to titers of human convalescent sera reported in each study, a robust correlation was seen between neutralizing titer and efficacy (ρ = 0.79) and binding antibody titer and efficacy (ρ = 0.93), despite geographically diverse study populations subject to different forces of infection and circulating variants, and use of different endpoints, assays, convalescent sera panels and manufacturing platforms. Together with evidence from natural history studies and animal models, these results support the use of post-immunization antibody titers as the basis for establishing a correlate of protection for COVID-19 vaccines

Joining Together to Build More: The New England Software Carpentry Library Consortium

In 2017 a group of academic library and information technology staff from institutions across New England piloted a process of joining The Carpentries, an organization developed to train researchers in essential computing skills and practices for automating and improving their handling of data, as a consortium. The New England Software Carpentry Library Consortium (NESCLiC) shared a gold-level tier membership to become a Carpentries member organization. NESCLiC members attended a Software Carpentry workshop together and then participated in instructor training as a cohort, collaborating on learning the material, practicing, and beginning to host and teach workshops as a group. This article describes both the successes and challenges of forming this new consortium, suggests good practices for those who might wish to form similar collaborations, and discusses the future of this program and other efforts to help researchers improve their computing and data handling skills

Gas Accretion by Star Clusters and the Formation of Ultraluminous X-ray Sources from Cusps of Compact Remnants

Here we show that the overabundance of ultra-luminous, compact X-ray sources (ULXs) associated with moderately young clusters in interacting galaxies such as the Antennae and Cartwheel can be given an alternative explanation that does not involve the presence of intermediate mass black holes (IMBHs). We argue that gas density within these systems is enhanced by the collective potential of the cluster prior to being accreted onto the individual cluster members and, as a result, the aggregate X-ray luminosity arising from the neutron star cluster members can exceed $>10^{39} {\rm erg s^{-1}}$. Various observational tests to distinguish between IMBHs and accreting neutron star cusps are discussed.Comment: 4 pages, 3 figures, accepted to ApJ

External Mass Accumulation onto Core Potentials: Implications for Star Clusters, Galaxies and Galaxy Clusters

Accretion studies have been focused on the flow around bodies with point mass gravitational potentials, but few general results are available for non-point mass distributions. Here, we study the accretion flow onto non-divergent, core potentials moving through a background medium. We use Plummer and Hernquist potentials as examples to study gas accretion onto star clusters, dwarf and large galaxy halos and galaxy clusters in a variety of astrophysical environments. The general conditions required for a core potential to collectively accrete large quantities of gas from the external medium are derived using both simulations and analytic results. The consequences of large mass accumulation in galaxy nuclei, dwarf galaxies and star clusters are twofold. First, if the gas cools effectively star formation can be triggered, generating new stellar members in the system. Second, if the collective potential of the system is able to alter the ambient gas properties before the gas is accreted onto the individual core members, the augmented mass supply rates could significantly alter the state of the various accreting stellar populations and result in an enhanced central black hole accretion luminosity.Comment: 24 pages, 15 figures, accepted to Ap

New Limits on an Intermediate Mass Black Hole in Omega Centauri: II. Dynamical Models

We present a detailed dynamical analysis of the projected density and kinematical data available for the globular cluster Omega Cen. We solve the spherical anisotropic Jeans equation to predict the projected profiles of the RMS velocity in each of the three orthogonal coordinate directions (line of sight, proper motion radial, and proper motion tangential). We fit the models to new HST star count and proper motion data near the cluster center presented in Paper I, combined with existing ground-based measurements. We also derive and model the Gauss-Hermite moments of the observed proper motion distributions. The projected density profile is consistent with being flat near the center, with an upper limit gamma=0.07 on the central logarithmic slope. The RMS proper motion profile is also consistent with being flat near the center, and there are no unusually fast-moving stars. The models provide a good fit and yield a 1-sigma upper limit MBH < 1.2E4 solar masses on the mass of a possible intermediate-mass black hole (IMBH). The inferred upper limit corresponds to MBH/Mtot < 0.43%. We combine this with results for other clusters and discuss the implications for globular cluster IMBH demographics. Tighter limits will be needed to rule out or establish whether globular clusters follow the same black hole demographics correlations as galaxies. The arguments put forward by Noyola et al. (2008) to suspect an IMBH in Omega Cen are not confirmed by our study; the IMBH mass they suggested is firmly ruled out.Comment: 28 pages, 11 figures, ApJ in press. v2 includes additions in response to referee comment

Using Endogenous MicroRNA Expression Patterns to Visualize Neural Differentiation of Human Pluripotent Stem Cells

Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells

Towards a population-based threshold of protection for COVID-19 vaccines

Correlates of protection for COVID-19 vaccines are urgently needed to license additional vaccines. We measured immune responses to four COVID-19 vaccines of proven efficacy using a single serological platform. IgG anti-Spike antibodies were highly correlated with ID50 neutralization in a validated pseudoviral assay and correlated significantly with efficacies for protection against infection with wild-type, alpha and delta variant SARS-CoV-2 virus. The protective threshold for each vaccine was calculated for IgG anti-Spike antibody. The mean protective threshold for all vaccine studies for WT virus was 154 BAU/ml (95 %CI 42–559), and for studies with antibody distributions that enabled precise estimation of thresholds (i.e. leaving out 2-dose mRNA regimens) was 60 BAU/ml (95 %CI 35–102). We propose that the proportion of individuals with responses above the appropriate protective threshold together with the geometric mean concentration can be used in comparative non-inferiority studies with licensed vaccines to ensure that new vaccines will be efficacious