An Enlightened American: The Political Ideology of Thomas Hutchinson on the Eve of the Revolutionary Crisis

This dissertation examines the political, social and philosophical views of Massachusetts' last royal governor, Thomas Hutchinson, as expressed in his 1764-1773 work, the History of Massachusetts-Bay. It is my contention that this work provides unique insights into the ideology of this important eighteenth century figure, and the values that would motivate him during the Revolutionary crisis. Years before the turmoil of the Revolutionary crisis began, Hutchinson had already given deep reflection to many of the same political and philosophical issues that would resurface in the imperial struggle. Hutchinson's historical work, written for both colonial and English audiences, provides significant insight into Hutchinson's political ideology and value system as that struggle opened. I will concentrate my analysis on Volume One, the part of Hutchinson's work written before 1765. This thesis will focus on three issues covered in the first volume: Massachusetts' struggle for religious orthodoxy in the seventeenth century, the colony's early Indian wars and relations with the Indians, and the colonists' century-long struggle with England over their original charter. My dissertation will demonstrate that Hutchinson's worldview was, no less than many of his adversaries in the Revolution Crisis, that of a man of the Enlightenment, and an American with both deep roots and great pride in his native land. Throughout Volume One of the History, Hutchinson stressed the importance of balanced government, the necessity of a just and impartial rule of law, the need for moderation and republican virtue in government, and the dangers of prejudice and popular passion. His views on a wide variety of issues grew, at least in part, out of his understanding of Massachusetts' colonial past, and his immersion in the literature of the American Enlightenment. These views were clearly revealed in the History, a work which has until now been under-utilized as a key into the man's ideology

Socioeconomic inequalities in breast and cervical screening coverage in England: Are we closing the gap?

Objective: Health policy in the UK is committed to tackling inequalities in cancer screening participation. We examined whether socioeconomic inequalities in breast and cervical cancer screening participation in England have reduced over five years.  Methods: Cross-sectional analyses compared cervical and breast screening coverage between 2007/8 and 2012/13 in Primary Care Trusts (PCTs) in England in relation to area-level income deprivation.  Results: At the start and the end of this five year period, there were socioeconomic inequalities in screening coverage for breast and cervical screening. Inequalities were highest for breast screening. Over time, the coverage gap between the highest and lowest quintiles of income deprivation significantly reduced for breast screening (from 12.3 to 8.3 percentage points), but not for cervical screening (5.3 to 4.9 percentage points).  Conclusions: Efforts to reduce screening inequalities appear to have resulted in a significant improvement in equitable delivery of breast screening, although not of cervical screening. More work is needed to understand the differences, and see whether broader lessons can be learned from the reduction of inequalities in breast screening participation

Exploring the experiences of Indigenous women who participated in a 'follow-through' journey within a Bachelor of Midwifery program

[Extract] Summary: • The women interviewed in our study reported the many benefits of having an Indigenous midwifery student provide them with Continuity of Care • Increasing the number of Aboriginal & Torres Strait Islander midwives is essential to improving health outcomes for Aboriginal & Torres Strait Islander familie

Implementations of a model of physical sorting

We define a computational model of physical devices that have a parallel atomic operation that transforms their input, an unordered list, in such a way that their output, the sorted list, can be sequentially read off in linear time. We show that several commonly-used scientific laboratory techniques (from biology, chemistry, and physics) are instances of the model and we provide experimental implementations

Implementations of a model of physical sorting

We define a computational model of physical devices that have a parallel atomic operation that transforms their input, an unordered list, in such a way that their output, the sorted list, can be sequentially read off in linear time. We show that several commonly-used scientific laboratory techniques (from biology, chemistry, and physics) are instances of the model and we provide experimental implementations

Prioritising Informed Health Choices Key Concepts for those impacted by cancer: a protocol [version 1; peer review: 2 approved]

Background: Few areas of health have been as insidiously influenced by misinformation as cancer. Thus, interventions that can help people impacted by cancer reduce the extent to which they are victims of misinformation are necessary. The Informed Health Choices (IHC) initiative has developed Key Concepts that can be used in the development of interventions for evaluating the trustworthiness of claims about the effects of health treatments. We are developing an online education programme called Informed Health Choices-Cancer (IHC-C) based on the IHC Key Concepts. We will provide those impacted by cancer with the knowledge and skills necessary to think critically about the reliability of health information and claims and make informed choices. Methods: We will establish a steering group (SG) of 12 key stakeholders, including oncology specialists and academics. In addition, we will establish a patient and public involvement (PPI) panel of 20 people impacted by cancer. After training the members on the Key Concepts and the prioritisation process, we will conduct a two-round prioritisation process. In the first round, 12 SG members and four PPI panel members will prioritise Key Concepts for inclusion. In the second round, the remaining 16 PPI members will undertake the prioritisation based on the prioritised Key Concepts from the first round. Participants in both rounds will use a structured judgement form to rate the importance of the Key Concepts for inclusion in the online IHC-C programme. A consensus meeting will be held, where members will reach a consensus on the Key Concepts to be included and rank the order in which the prioritised Key Concepts will be addressed in the IHC-C programme. Conclusions: At the end of this process, we will identify which Key Concepts should be included and the order in which they should be addressed in the IHC-C programme

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin