187 research outputs found
Proto-magnetar jets as central engines for broad-lined Type Ic supernovae
A subset of type Ic supernovae (SNe Ic), broad-lined SNe Ic (SNe Ic-bl), show
unusually high kinetic energies ( erg) which cannot be explained
by the energy supplied by neutrinos alone. Many SNe Ic-bl have been observed in
coincidence with long gamma-ray bursts (GRBs) which suggests a connection
between SNe and GRBs. A small fraction of core-collapse supernovae (CCSNe) form
a rapidly-rotating and strongly-magnetized protoneutron star (PNS), a
proto-magnetar. Jets from such magnetars can provide the high kinetic energies
observed in SNe Ic-bl and also provide the connection to GRBs. In this work we
use the jetted outflow produced in a 3D CCSN simulation from a consistently
formed proto-magnetar as the central engine for full-star explosion
simulations. We extract a range of central engine parameters and find that the
extracted engine energy is in the range of erg, the engine time-scale in the range of s and the
engine half-opening angle in the range of . Using these as
central engines, we perform 2D special-relativistic (SR) hydrodynamic (HD) and
radiation transfer simulations to calculate the corresponding light curves and
spectra. We find that these central engine parameters successfully produce SNe
Ic-bl which demonstrates that jets from proto-magnetars can be viable engines
for SNe Ic-bl. We also find that only the central engines with smaller opening
angles () form a GRB implying that GRB formation is likely
associated with narrower jet outflows and Ic-bl's without GRBs may be
associated with wider outflows.Comment: 13 pages, 12 figure
The effects of transcutaneous spinal cord stimulation delivered with and without high-frequency modulation on spinal and corticospinal excitability
Transcutaneous spinal cord stimulation (TSCS) has been shown to improve motor recovery in people with spinal cord injury (SCI). Some groups deliver TSCS modulated with a kHz-frequency (TSCS–kHz); the intensity used for TSCS–kHz is usually set based on the motor threshold for TSCS, even though TSCS–kHz threshold is considerably higher than TSCS. As a result, TSCS–kHz interventions tend to be delivered at low intensities with respect to the motor threshold (~40%). In this study, we compared the effects of sub-threshold TSCS and TSCS–kHz, when delivered at similar intensity relative to their own motor threshold. Experiment I compared the after-effects of 20 min of sub-threshold (40% threshold) TSCS and TSCS–kHz on spinal and corticospinal excitability in able-bodied participants. Experiment II assessed the dose–response relationship of delivering short (10-pulse) trains of TSCS and TSCS–kHz at three different current intensities relative to the threshold (40%, 60%, and 80%). Experiment I found that 20 min of TSCS–kHz at a 40% threshold decreased posterior root reflex amplitude (p < 0.05), whereas TSCS did not. In experiment II, motor-evoked potential (MEP) amplitude increased following short trains of TSCS and TSCS–kHz of increasing intensity. MEP amplitude was significantly greater for TSCS–kHz compared with TSCS when delivered at 80% of the threshold (p < 0.05). These results suggest that TSCS and TSCS–kHz have different effects when delivered at similar intensity relative to their own threshold; both for immediate effects on corticospinal excitability and following prolonged stimulation on spinal excitability. These different effects may be utilized for optimal rehabilitation in people with SCI
The Immediate and Short-Term Effects of Transcutaneous Spinal Cord Stimulation and Peripheral Nerve Stimulation on Corticospinal Excitability
Rehabilitative interventions involving electrical stimulation show promise for neuroplastic recovery in people living with Spinal Cord Injury (SCI). However, the understanding of how stimulation interacts with descending and spinal excitability remain unclear. In this study we compared the immediate and short-term (within a few minutes) effects of pairing Transcranial Magnetic Stimulation (TMS) with transcutaneous Spinal Cord stimulation (tSCS) and Peripheral Nerve Stimulation (PNS) on Corticospinal excitability in healthy subjects. Three separate experimental conditions were assessed. In Experiment I, paired associative stimulation (PAS) was applied, involving repeated pairing of single pulses of TMS and tSCS, either arriving simultaneously at the spinal motoneurones (PAS0ms) or slightly delayed (PAS5ms). Corticospinal and spinal excitability, and motor performance, were assessed before and after the PAS interventions in 24 subjects. Experiment II compared the immediate effects of tSCS and PNS on corticospinal excitability in 20 subjects. Experiment III compared the immediate effects of tSCS with tSCS delivered at the same stimulation amplitude but modulated with a carrier frequency (in the kHz range) on corticospinal excitability in 10 subjects. Electromyography (EMG) electrodes were placed over the Tibialis Anterior (TA) soleus (SOL) and vastus medialis (VM) muscles and stimulation electrodes (cathodes) were placed on the lumbar spine (tSCS) and lateral to the popliteal fossa (PNS). TMS over the primary motor cortex (M1) was paired with tSCS or PNS to produce Motor Evoked Potentials (MEPs) in the TA and SOL muscles. Simultaneous delivery of repetitive PAS (PAS0ms) increased corticospinal excitability and H-reflex amplitude at least 5 min after the intervention, and dorsiflexion force was increased in a force-matching task. When comparing effects on descending excitability between tSCS and PNS, a subsequent facilitation in MEPs was observed following tSCS at 30-50 ms which was not present following PNS. To a lesser extent this facilitatory effect was also observed with HF- tSCS at subthreshold currents. Here we have shown that repeated pairing of TMS and tSCS can increase corticospinal excitability when timed to arrive simultaneously at the alpha-motoneurone and can influence functional motor output. These results may be useful in optimizing stimulation parameters for neuroplasticity in people living with SCI
Prevalence and characteristics of gastrointestinal infections in men who have sex with men diagnosed with rectal chlamydia infection in the UK: an 'unlinked anonymous' cross-sectional study.
INTRODUCTION: Gastrointestinal infections (GII) can cause serious ill health and morbidity. Although primarily transmitted through faecal contamination of food or water, transmission through sexual activity is well described, especially among men who have sex with men (MSM). METHODS: We investigated the prevalence of GIIs among a convenience sample of MSM who were consecutively diagnosed with rectal Chlamydia trachomatis (CT) at 12 UK genitourinary medicine clinics during 10 weeks in 2012. Residual rectal swabs were coded, anonymised and tested for Shigella, Campylobacter, Salmonella, shiga toxin-producing Escherichia coli and enteroaggregative E. coli (EAEC) using a real-time PCR. Results were linked to respective coded and anonymised clinical and demographic data. Associations were investigated using Fisher's exact tests. RESULTS: Of 444 specimens tested, overall GII prevalence was 8.6% (95% CI 6.3% to 11.6%): 1.8% (0.9% to 3.6%) tested positive for Shigella, 1.8% (0.9% to 3.6%) for Campylobacter and 5.2% (3.5% to 7.7%) for EAEC. No specimens tested positive for Salmonella or other diarrhoeagenic E. coli pathotypes. Among those with any GII, 14/30 were asymptomatic (2/7 with Shigella, 3/6 with Campylobacter and 9/17 with EAEC). Shigella prevalence was higher in MSM who were HIV-positive (4.7% (2.1% to 10.2%) vs 0.5%(0.1% to 3.2%) in HIV-negative MSM; p=0.01). CONCLUSIONS: In this small feasibility study, MSM with rectal CT appeared to be at appreciable risk of GII. Asymptomatic carriage may play a role in sexual transmission of GII
Low-mass planets in nearly inviscid disks: Numerical treatment
Embedded planets disturb the density structure of the ambient disk and
gravitational back-reaction will induce possibly a change in the planet's
orbital elements. The accurate determination of the forces acting on the planet
requires careful numerical analysis. Recently, the validity of the often used
fast orbital advection algorithm (FARGO) has been put into question, and
special numerical resolution and stability requirements have been suggested. In
this paper we study the process of planet-disk interaction for small mass
planets of a few Earth masses, and reanalyze the numerical requirements to
obtain converged and stable results. One focus lies on the applicability of the
FARGO-algorithm. Additionally, we study the difference of two and
three-dimensional simulations, compare global with local setups, as well as
isothermal and adiabatic conditions. We study the influence of the planet on
the disk through two- and three-dimensional hydrodynamical simulations. To
strengthen our conclusions we perform a detailed numerical comparison where
several upwind and Riemann-solver based codes are used with and without the
FARGO-algorithm.
With respect to the wake structure and the torque density acting on the
planet we demonstrate that the FARGO-algorithm yields correct results, and that
at a fraction of the regular cpu-time. We find that the resolution requirements
for achieving convergent results in unshocked regions are rather modest and
depend on the pressure scale height of the disk. By comparing the torque
densities of 2D and 3D simulations we show that a suitable vertical averaging
procedure for the force gives an excellent agreement between the two. We show
that isothermal and adiabatic runs can differ considerably, even for adiabatic
indices very close to unity.Comment: accepted by Astronomy & Astrophysic
Planetary population synthesis
In stellar astrophysics, the technique of population synthesis has been
successfully used for several decades. For planets, it is in contrast still a
young method which only became important in recent years because of the rapid
increase of the number of known extrasolar planets, and the associated growth
of statistical observational constraints. With planetary population synthesis,
the theory of planet formation and evolution can be put to the test against
these constraints. In this review of planetary population synthesis, we first
briefly list key observational constraints. Then, the work flow in the method
and its two main components are presented, namely global end-to-end models that
predict planetary system properties directly from protoplanetary disk
properties and probability distributions for these initial conditions. An
overview of various population synthesis models in the literature is given. The
sub-models for the physical processes considered in global models are
described: the evolution of the protoplanetary disk, the planets' accretion of
solids and gas, orbital migration, and N-body interactions among concurrently
growing protoplanets. Next, typical population synthesis results are
illustrated in the form of new syntheses obtained with the latest generation of
the Bern model. Planetary formation tracks, the distribution of planets in the
mass-distance and radius-distance plane, the planetary mass function, and the
distributions of planetary radii, semimajor axes, and luminosities are shown,
linked to underlying physical processes, and compared with their observational
counterparts. We finish by highlighting the most important predictions made by
population synthesis models and discuss the lessons learned from these
predictions - both those later observationally confirmed and those rejected.Comment: 47 pages, 12 figures. Invited review accepted for publication in the
'Handbook of Exoplanets', planet formation section, section editor: Ralph
Pudritz, Springer reference works, Juan Antonio Belmonte and Hans Deeg, Ed
Massive black hole science with eLISA
The evolving Laser Interferometer Space Antenna (eLISA) will revolutionize our understanding of the formation and evolution of massive black holes (MBHs) along cosmic history, by probing massive black hole binaries (MBHBs) in the 10(3) - 10(7) M-circle dot range out to redshift z greater than or similar to 10. High signal-to-noise ratio detections of similar to 10 - 100 MBHB coalescences per year will allow accurate measurements of the parameters of individual MBHBs (such as their masses, spins and luminosity distance), and a deep understanding of the underlying cosmic MBH parent population. This wealth of unprecedented information can lead to breakthroughs in many areas of physics, including astrophysics, cosmology and fundamental physics. We review the current status of the field, recent progress and future challenges
- …