229 research outputs found
Towards a just and fair Internet: applying Rawls’ principles of justice to Internet regulation
I suggest that the social justice issues raised by Internet regulation be exposed and examined by using a methodology adapted from that described by John Rawls in A Theory of Justice. Rawls’ theory uses the hypothetical scenario of people deliberating about the justice of social institutions from the ‘original position’ as a method of removing bias in decision-making about justice. The original position imposes a ‘veil of ignorance’ that hides the particular circumstances of individuals from them so that they will not be influenced by self-interest. I adapt Rawls’ methodology by introducing an abstract description of information technology to those deliberating about justice from within the original position. This abstract description focuses on information devices that users can use to access information (and which may record information about them as well) and information networks that information devices use to communicate. The abstractness of this description prevents the particular characteristics of the Internet and the computing devices in use from influencing the decisions about the just use and regulation of information technology and networks. From this abstract position, the principles of justice that the participants accept for the rest of society will also apply to the computing devices people use to communicate, and to Internet regulatio
Towards a just and fair Internet: applying Rawls’ principles of justice to Internet regulation
Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross
An F broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits. Thirty-six additional QTL were identified when the assumption that QTL were fixed in the grandparent lines was relaxed. QTL with large effects on the lengths of the tarsometatarsus, tibia and femur, and the weights of the tibia and femur were identified on GGA4 between 217 and 249 cM. Six QTL for skeletal traits were identified that did not co-locate with genome wide significant QTL for body weight and two body weight QTL did not coincide with skeletal trait QTL. Significant evidence of imprinting was found in ten of the QTL and QTL x sex interactions were identified for 22 traits. Six alleles from the broiler line for weight- and size-related skeletal QTL were positive. Negative alleles for bone quality traits such as tibial dyschondroplasia, leg bowing and tibia twisting generally originated from the layer line suggesting that the allele inherited from the broiler is more protective than the allele originating from the layer
Quantum theory of massless (p,0)-forms
We describe the quantum theory of massless (p,0)-forms that satisfy a
suitable holomorphic generalization of the free Maxwell equations on Kaehler
spaces. These equations arise by first-quantizing a spinning particle with a
U(1)-extended local supersymmetry on the worldline. Dirac quantization of the
spinning particle produces a physical Hilbert space made up of (p,0)-forms that
satisfy holomorphic Maxwell equations coupled to the background Kaehler
geometry, containing in particular a charge that measures the amount of
coupling to the U(1) part of the U(d) holonomy group of the d-dimensional
Kaehler space. The relevant differential operators appearing in these equations
are a twisted exterior holomorphic derivative and its hermitian conjugate
(twisted Dolbeault operators with charge q). The particle model is used to
obtain a worldline representation of the one-loop effective action of the
(p,0)-forms. This representation allows to compute the first few heat kernel
coefficients contained in the local expansion of the effective action and to
derive duality relations between (p,0) and (d-p-2,0)-forms that include a
topological mismatch appearing at one-loop.Comment: 32 pages, 3 figure
On duality symmetries of supergravity invariants
The role of duality symmetries in the construction of counterterms for
maximal supergravity theories is discussed in a field-theoretic context from
different points of view. These are: dimensional reduction, the question of
whether appropriate superspace measures exist and information about non-linear
invariants that can be gleaned from linearised ones. The former allows us to
prove that F-term counterterms cannot be E7(7)-invariant in D=4, N=8
supergravity or E6(6)-invariant in D=5 maximal supergravity. This is confirmed
by the two other methods which can also be applied to D=4 theories with fewer
supersymmetries and allow us to prove that N=6 supergravity is finite at three
and four loops and that N=5 supergravity is three-loop finite.Comment: Clarification of arguments and their consistency with higher
dimensional divergences added, e.g. we prove the 5D 4L non-renormalisation
theorem. The 4L N=6 divergence is also ruled out. References adde
On duality symmetry in perturbative quantum theory
Non-compact symmetries of extended 4d supergravities involve duality
rotations of vectors and thus are not manifest off-shell invariances in
standard "second-order" formulation. To study how such symmetries are realised
in the quantum theory we consider examples in 2 dimensions where vector-vector
duality is replaced by scalar-scalar one. Using a "doubled" formulation, where
fields and their momenta are treated on an equal footing and the duality
becomes a manifest symmetry of the action (at the expense of Lorentz symmetry),
we argue that the corresponding on-shell quantum effective action or S-matrix
are duality symmetric as well as Lorentz invariant. The simplest case of
discrete Z_2 duality corresponds to a symmetry of the S-matrix under flipping
the sign of the negative-chirality scalars in 2 dimensions or phase rotations
of chiral (definite-helicity) parts of vectors in 4 dimensions. We also briefly
discuss some 4d models and comment on implications of our analysis for extended
supergravities.Comment: 21 pages, Latex v2: comments and references added v3: references and
minor comments adde
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Health-related quality of life in Huntington’s Disease patients: a comparison of proxy assessment and patient self-rating using the disease-specific Huntington’s Disease health-related quality of life questionnaire (HDQoL)
Huntington’s disease (HD) is a fatal, neurodegenerative disease for which there is no known cure. Proxy evaluation is relevant for HD as its manifestation might limit the ability of persons to report their health-related quality of life (HrQoL). This study explored patient–proxy ratings of HrQoL of persons at different stages of HD, and examined factors that may affect proxy ratings. A total of 105 patient–proxy pairs completed the Huntington’s disease health-related quality of life questionnaire (HDQoL) and other established HrQoL measures (EQ-5D and SF-12v2). Proxy–patient agreement was assessed in terms of absolute level (mean ratings) and intraclass correlation. Proxies’ ratings were at a similar level to patients’ self-ratings on an overall Summary Score and on most of the six Specific Scales of the HDQoL. On the Specific Hopes and Worries Scale, proxies on average rated HrQoL as better than patients’ self-ratings, while on both the Specific Cognitive Scale and Specific Physical and Functional Scale proxies tended to rate HrQoL more poorly than patients themselves. The patient’s disease stage and mental wellbeing (SF-12 Mental Component scale) were the two factors that primarily affected proxy assessment. Proxy scores were strongly correlated with patients’ self-ratings of HrQoL, on the Summary Scale and all Specific Scales. The patient–proxy correlation was lower for patients at moderate stages of HD compared to patients at early and advanced stages. The proxy report version of the HDQoL is a useful complementary tool to self-assessment, and a promising alternative when individual patients with advanced HD are unable to self-report
Sigma-model for Generalized Composite p-branes
A multidimensional gravitational model containing several dilatonic scalar
fields and antisymmetric forms is considered. The manifold is chosen in the
form M = M_0 x M_1 x ... x M_n, where M_i are Einstein spaces (i > 0). The
block-diagonal metric is chosen and all fields and scale factors of the metric
are functions on M_0. For the forms composite (electro-magnetic) p-brane ansatz
is adopted. The model is reduced to gravitating self-interacting sigma-model
with certain constraints. In pure electric and magnetic cases the number of
these constraints is m(m - 1)/2 where m is number of 1-dimensional manifolds
among M_i. In the "electro-magnetic" case for dim M_0 = 1, 3 additional m
constraints appear. A family of "Majumdar-Papapetrou type" solutions governed
by a set of harmonic functions is obtained, when all factor-spaces M_k are
Ricci-flat. These solutions are generalized to the case of non-Ricci-flat M_0
when also some additional "internal" Einstein spaces of non-zero curvature are
added to M. As an example exact solutions for D = 11 supergravity and related
12-dimensional theory are presented.Comment: 33 pages, Latex. Some corrections and rearrangements are mad
The Evolving Landscape of the Economics of HIV Treatment and Prevention
Bohdan Nosyk and Julio Montaner argue that the cost-effectiveness of HAART roll out has been significantly underestimated because economic analyses haven't yet taken into account the beneficial impact of HAART on HIV transmission
Bosonic excitations of the AdS4 Reissner-Nordstrom black hole
We study the long-lived modes of the charge density and energy density
correlators in the strongly-coupled, finite density field theory dual to the
AdS4 Reissner-Nordstrom black hole. For small momenta q<<\mu, these correlators
contain a pole due to sound propagation, as well as a pole due to a long-lived,
purely imaginary mode analogous to the \mu=0 hydrodynamic charge diffusion
mode. As the temperature is raised in the range T\lesssim\mu, the sound
attenuation shows no significant temperature dependence. When T\gtrsim\mu, it
quickly approaches the \mu=0 hydrodynamic result where it decreases like 1/T.
It does not share any of the temperature-dependent properties of the 'zero
sound' of Landau Fermi liquids observed in the strongly-coupled D3/D7 field
theory. For such small momenta, the energy density spectral function is
dominated by the sound mode at all temperatures, whereas the charge density
spectral function undergoes a crossover from being dominated by the sound mode
at low temperatures to being dominated by the diffusion mode when T \mu^2/q.
This crossover occurs due to the changing residue at each pole. We also compute
the momentum dependence of these spectral functions and their corresponding
long-lived poles at fixed, low temperatures T<<\mu.Comment: 33 pages, 21 figures, 6 animation
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