On the statistical interpretation of optical rogue waves

Numerical simulations are used to discuss various aspects of "optical rogue wave" statistics observed in noise-driven fiber supercontinuum generation associated with highly incoherent spectra. In particular, we consider how long wavelength spectral filtering influences the characteristics of the statistical distribution of peak power, and we contrast the statistics of the spectrally filtered SC with the statistics of both the peak power of the most red-shifted soliton in the SC and the maximum peak power across the full temporal field with no spectral selection. For the latter case, we show that the unfiltered statistical distribution can still exhibit a long-tail, but the extreme-events in this case correspond to collisions between solitons of different frequencies. These results confirm the importance of collision dynamics in supercontinuum generation. We also show that the collision-induced events satisfy an extended hydrodynamic definition of "rogue wave" characteristics.Comment: Paper accepted for publication in the European Physical Journal ST, Special Topics. Discussion and Debate: Rogue Waves - towards a unifying concept? To appear 201

Modulation control and spectral shaping of optical fiber supercontinuum generation in the picosecond regime

Numerical simulations are used to study how fiber supercontinuum generation seeded by picosecond pulses can be actively controlled through the use of input pulse modulation. By carrying out multiple simulations in the presence of noise, we show how tailored supercontinuum Spectra with increased bandwidth and improved stability can be generated using an input envelope modulation of appropriate frequency and depth. The results are discussed in terms of the non-linear propagation dynamics and pump depletion.Comment: Aspects of this work were presented in Paper ThJ2 at OECC/ACOFT 2008, Sydney Australia 7-10 July (2008). Journal paper submitted for publication 30 July 200

Individual and cumulative measures of knee joint load associate with T2 relaxation times of knee cartilage in young, uninjured individuals: A pilot study

Background: Articular cartilage structure and chondrocyte health are sensitive and reliant on dynamic joint loading during activities. The purpose of this pilot study was to determine the association between measures of individual and cumulative knee joint loading with T2 relaxation times in the knee cartilage of young individuals without knee injury. Methods: Twelve participants (17–30 years old) without history of knee injury or surgery completed MRI, physical activity (PA), and biomechanical gait testing. T2 relaxation times were calculated in the cartilage within the patella and lateral and medial compartments. Accelerometry was used to measure mean daily step counts, minutes of PA, and % sedentary time over 7 days. Vertical ground reaction force, external knee joint moments and peak knee flexion angle were measured during stance phase of gait using three-dimensional motion capture. Cumulative knee joint loading was calculated as daily step count by external knee joint moment impulse. The relationship between measures of knee joint loading and T2 relaxation times was assessed using Pearson correlations. Results: Higher T2 relaxation times in the femoral and tibial cartilage were consistently correlated to greater body mass, daily step counts, moderate and vigorous PA, and peak knee joint moments (r = 0.10–0.84). Greater cumulative knee flexion and adduction loading was associated with higher T2 relaxation times in the femoral and tibial cartilage (r = 0.16–0.65). Conclusion: Preliminary findings suggest that individual loading factors and cumulative knee joint loading are associated with higher T2 relaxation times in the articular cartilage of young, healthy knees

Carbapenem-resistant Enterobacteriaceae infections: Results from a retrospective series and implications for the design of prospective clinical trials

Background. The increasing incidence of multidrug-resistant Gram negatives, such as carbapenem-resistant Enterobacteriaceae (CRE), has resulted in a critical need for new antimicrobials. Most studies of new antimicrobials have been performed in patients with nondrug-resistant pathogens. We performed a retrospective analysis of patients with CRE infections to inform the design of phase 3 clinical trials. Methods. This was a retrospective study at 22 centers in 4 countries. Baseline data, treatment, and outcomes were collected in patients with complicated urinary tract infection (cUTI)/acute pyelonephritis (AP), hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), and bacteremia due to CRE. Results. Two hundred fifty-six cases of CRE infection were identified: 75 cUTI/AP, 21 HABP, 20 VABP, and 140 bacteremia. The patient population had significant comorbidities: 32.8% had chronic renal insufficiency, and 26.2% were immunocompromised. Illness severity at presentation was high: 29.3% presented with septic shock. Treatment regimens varied widely; however, a majority of patients received combination therapy. Outcomes were universally poor (28-day mortality was 28.1%) across all sites of infection, particularly in dialysis patients and those with sepsis. Conclusions. The CRE infections occured in patients with substantial comorbidities and were associated with high mortality and low rates of clinical cure with available antibiotics. Patients with these comorbidities are often excluded from enrollment in clinical trials for registration of new drugs. These results led to changes in the inclusion/exclusion criteria of a phase 3 trial to better represent the patient population with CRE infections and enable enrollment. Observational studies may become increasingly important to guide clinical trial design, inform on the existing standard of care, and provide an external control for subsequent trials. © The Author 2017

Challenges and Opportunities of Lean Remanufacturing

Lean philosophy, which promotes business excellence through continuous improvement, originates from the Japanese car manufacturer, Toyota’s Production System (TPS). An area where lean has not been fully explored is remanufacturing, a process that brings used products back to useful life. Remanufacturing is often a more complex process than manufacturing due to the uncertainty of process steps/time and part quality/quantity. This study explored remanufacturing by identifying its challenges and opportunities in becoming lean. The challenges of a lean remanufacturing system do not exceed its advantages. Although some researchers state that it is difficult or even impossible to apply lean principles to remanufacturing, this research utilizes lean as a continuous improvement philosophy that focuses on improving the remanufactured products’ quality, process lead times, and inventory levels. ÅterProdukt, KEA