A list of Philippine mosquitoes (Diptera: Culicidae).

Volume: 1

Non-SELEX isolation of DNA aptamers for the homogeneous-phase fluorescence anisotropy sensing of tau Proteins

International audienc

The Aedes Mosquitoes of the Philippine Islands. 1. Keys to Species. Subgenera Mucidus, Ochlerotatus, and Finlaya (Diptera, Culicidae)

Volume: 5Start Page: 211End Page: 25

Noncoding RNAs in Cancer Medicine

Several signalling proteins involved in cell growth and differentiation represent attractive candidate targets for cancer diagnosis and/or therapy since they can act as oncogenes. Because of their high specificity and low immunogeneicity, using artificial small noncoding RNA (ncRNAs) as therapeutics has recently become a highly promising and rapidly expanding field of interest. Indeed, ncRNAs may either interfere with RNA transcription, stability, translation or directly hamper the function of the targets by binding to their surface. The recent finding that the expression of several genes is under the control of small single-stranded regulatory RNAs, including miRNAs, makes these genes as appropriate targets for ncRNA gene silencing. Furthermore, another class of small ncRNA, aptamers, act as high-affinity ligands and potential antagonists of disease-associated proteins. We will review here the recent and innovative methods that have been developed and the possible applications of ncRNAs as inhibitors or tracers in cancer medicine

Voter en Inde : symboles électoraux, système de partis et vote non individuel

Le taux élevé d'analphabétisme en Inde a conduit cette démocratie (qui a organisé dix élections générales depuis l'indépendance) à élaborer une procédure électorale reposant sur l'usage de symboles : l'acte de vote consiste à cocher dans l'isoloir le symbole correspondant au candidat et à la formation politique de son choix. Ce dispositif a eu des effets induits importants puisque l'attribution définitive d'un symbole aux partis réunissant un certain nombre de voix au niveau national ou régional a contribué à institutionnaliser le système des partis. Au-delà du recours aux symboles, la commission électorale s'est efforcée d'entourer l'acte de vote du plus grand nombre de garanties possibles pour assurer le secret du vote et le préserver des influences extérieures, de manière à réunir les conditions d'un vote rationnel et individuel. La sophistication des mesures prises paraît toutefois en décalage, d'une part, avec les formes concrètes de l'exercice du suffrage, les électeurs tendant à sélectionner leur candidat de façon collective (au niveau de la communauté religieuse ou de la sous-caste), d'autre part avec le vrai défi que constitue la montée des violences autour des bureaux de vote.Voting in India : electoral symbols, party system and non-individual voting - The high rate of illiteracy in India has led that democracy (which has had ten legislative elections since independence) to work out an électoral procedure based on the use of symbols : the voting act consists in checking on the ballot the symbol corresponding to the candidate and the political group of one's choice in the voting booth. This System has had many secondary effects, since the definitive attribution of symbols to parties obtaining a certain number of votes on the national or regional level has contributed to the institutionalization of the party system. Beyond the use of symbols, the Election Commission has endeavored to surround the voting act with the maximum of possible guarantees in order to ensure secrecy and to preserve it from outside influences so as to fulfil the conditions for rational and individual voting. The sophistication of the measures taken seems however, on one hand, to lag behind the concrete forms of exercising the suffrage, as the voters tend to select their candidates collectively (at the religions community or the subcaste level) ; on the other hand, it lags behind the real challenge, that of the rise of violence around voting places

Under the Dome - August 1994

Contents: Master Silver by Paul Storr, His Contemporaries and Followers.....p. 1 USC Faculty Art Exhibit .....p. 2 Master Silver by Paul Storr, His Contemporaries and Followers.....p. 2 Of Earth and Cotton.....p. 3 New Ways for Old Jugs: Tradition and Innovations at the Jugtown Pottery.....p. 3 A Natural History Discovery.....p. 3 Jane\u27s Journeys.....p. 4 South Carolina State Fair.....p. 5 McKissick Culture Columbia! for Children.....p. 6 Museum Hosts Fright Night.....p. 6 Tea and Lecture, Juliana Busbee and the Legacy of Jugtown Pottery \u27.....p. 7 Haunted Horseshoe and Museum of Horrors Offer Safe Halloween Fun.....p. 7 McKissick Museum Council.....p. 8 Jane Becomes a Permanent Fixture.....p. 8 Museum Bids a Fond Farewell.....p. 9 Advancement Committee.....p. 9 Special Events and Promotions Committee.....p. 9 Docent Activities.....p. 9 McKissick Members Fall Trip - Inside Washington, D.C......p. 10 Calendar.....p. 11 General Information.....p. 1

Identification of liver metastases with probe-based confocal laser endomicroscopy at two excitation wavelengths.

BACKGROUND: Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit. MATERIAL AND METHODS: The ability of fluorescent probe-based confocal laser endomicroscopy (pCLE) to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis (CRLM). To maximise information yield, two clinical fluorophores, fluorescein and indocyanine green (ICG) were injected and imaged in a dual wavelength approach (488 and 660 nm, respectively). Visual tissue characteristics on pCLE examination were compared with histological features. Fluorescence intensity in both tissues was statistically analysed to elucidate if this can be used to differentiate between normal and malignant tissue. RESULTS: Fluorescein (488 nm) enabled good visualisation of normal and CRLM tissue, whereas ICG (660 nm) visualisation was limited to normal liver tissue only. Fluorescence intensity in areas of CRLM was typically 53-100% lower than normal hepatic parenchyma. Using general linear mixed modelling and receiver operating characteristic analysis, high fluorescence intensity was found to be statistically more likely in normal hepatic tissue. CONCLUSION: Real time discrimination between normal liver parenchyma and metastatic tissue with pCLE examination of fluorescein and ICG is feasible. Employing two (rather than a single) fluorophores allows a combination of qualitative and quantitative characteristics to be used to distinguish between hepatic parenchyma and CRLM. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc

Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

Gliomas are the most common primary central nervous system tumors with a dismal prognosis. Despite recent advances in surgery, radiotherapy, and chemotherapy, current treatment regimens have a modest survival benefit. A crucial challenge is to deliver drugs effectively to invasive glioma cells residing in a sanctuary within the central nervous system. New therapies are essential, and oligonucleotide-based approaches, including antisense, microRNAs, small interfering RNAs, and nucleic acid aptamers, may provide a viable strategy. Thanks to their unique characteristics (low size, good affinity for the target, no immunogenicity, chemical structures that can be easily modified to improve their in vivo applications), these molecules may represent a valid alternative to antibodies particularly to overcome challenges presented by the blood-brain barrier. Here we will discuss recent results on the use of oligonucleotides that will hopefully provide new effective treatment for gliomas