Epigenetic aberrations and cancer

The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer

Influence of a road on a population in an ecological niche facing climate change

We introduce a model designed to account for the influence of a line with fast diffusion-such as a road or another transport network-on the dynamics of a population in an ecological niche. This model consists of a system of coupled reaction-diffusion equations set on domains with different dimensions (line / plane). We first show that the presence of the line is always deleterious and can even lead the population to extinction. Next, we consider the case where the niche is subject to a displacement, representing the effect of a climate change or of seasonal variation of resources. We find that in such case the presence of the line with fast diffusion can help the population to persist. We also study several qualitative properties of this system. The analysis is based on a notion of generalized principal eigenvalue developed by the authors in [5]

Dimensionality influence on passive scalar transport

We numerically investigate the advection of a passive scalar through an interface placed inside a decaying shearless turbulent mixing layer. We consider the system in both two and three dimensions. The dimensionality produces a different time scaling of the diffusion, which is faster in the two-dimensional case. Two intermittent fronts are generated at the margins of the mixing layer. During the decay these fronts present a sort of propagation in both the direction of the scalar flow and the opposite direction. In two dimensions, the propagation of the fronts exhibits a significant asymmetry with respect to the initial position of the interface and is deeper for the front merged in the high energy side of the mixing. In three dimensions, the two fronts remain nearly symmetrically placed. Results concerning the scalar spectra exponents are also presente

Philofluid turbulent flow database

A set of velocity and passive scalar fields and their statistics coming from direct numerical simulations and large-eddy simulations. The database includes: shearless mixings in two a three dimensions, turbulent channel flow, cavity flow. Username and password to access the netdisks is provided upon request

The prevalence, communicability and co-occurrence of inverted hallucinations: an overlooked global public health concern

While scientific understanding concerning the role of biological pathogenic agents in the transmission of communicable diseases has increased markedly in recent decades, the possibility of a psychological pathogenic agent that underlies the transmission of a number of key global public health concerns has largely been overlooked. The present paper identifies inverted hallucinations as a novel category of hallucination that not only reflect a key public health concern in their own right, but also appear to play an active role in the gradual transmission of diseases traditionally deemed to be non-communicable, such as mental health problems, obesity, and social media addiction. More specifically, the present paper delineates the assumptions and indicative empirical support underlying inverted hallucination theory as well as the characteristic features, functional consequences, prevalence, communicability, and co-occurrence of inverted hallucinations in the general population. Inverted hallucinations appear to be both globally prevalent and communicable, and are estimated to affect the average person on at least an occasional basis. Inverted hallucinations cause individuals to succumb to states of mind wandering that distorts their perception of what is happening in the present moment and increases their susceptibility to other deleterious health conditions. Moreover, inverted hallucinations appear to reflect a key overlooked public health need that not only stunt human potential and quality of life but also pose a risk to the wellbeing of the population globally.N