Soundpainting as a system for the collaborative creation of music in performance

Soundpainting is the method of "live composition" invented by New Yorkbased composer and saxophonist Walter Thompson. Using physical gestures for the spontaneous creation of music, Soundpainting therefore shares similarities with other types of gesture-based systems for music performance, such as orchestral conducting. Thompson himself (2006) describes his Soundpainting system as a "universal live composing sign language for the performing and visual arts," and therefore Soundpainting can be considered as a subset of other communication systems such as verbal and written language, kinesics, and paralanguage. This thesis outlines the general principles of Soundpainting as a system for setting into motion spontaneously created music. The author's aim is to describe Soundpainting in relation to the linguistic turn in Thompson's own definition. This opens the way to a sociosemiotic analysis, in which it is susceptible to examination in the light of some theories of language that have emerged in the course of the twentieth century. A theoretical framework is developed drawing on the work of such pioneers of semiotics as Saussure and Peirce, as well as the later work in philosophy of language of Wittgenstein, Barthes, Eco, Derrida, and others. The eclectic concerns of Soundpainting suggest situating Thompson's language in the context of current debates in critical theory about tonality, jazz, and improvisation as strategies for constructing identity. Soundpainting, by demonstrating that musical signification can be negotiated through consensus, problematizes the convention of the composer as the sole legitimating authority of the work. Considering Soundpainting as a processual activity, this dissertation outlines the general principles of Soundpainting as a system for the spontaneous creation of music. Emphasizing the process-based character of Soundpainting (and its affinity with other forms of improvised music) suggests that such categories of musical activity need to be studied from a different vantage point from that of historical musicology.Thesis (PhD (Music))--University of Pretoria, 2007.MusicPhDunrestricte

Systemic resistance and lipoxygenase-related defence response induced in tomato by Pseudomonas putida strain BTP1

BACKGROUND: Previous studies showed the ability of Pseudomonas putida strain BTP1 to promote induced systemic resistance (ISR) in different host plants. Since ISR is long-lasting and not conducive for development of resistance of the targeted pathogen, this phenomenon can take part of disease control strategies. However, in spite of the numerous examples of ISR induced by PGPR in plants, only a few biochemical studies have associated the protective effect with specific host metabolic changes. RESULTS: In this study, we showed the protective effect of this bacterium in tomato against Botrytis cinerea. Following treatment by P. putida BTP1, analyses of acid-hydrolyzed leaf extracts showed an accumulation of antifungal material after pathogen infection. The fungitoxic compounds thus mainly accumulate as conjugates from which active aglycones may be liberated through the activity of hydrolytic enzymes. These results suggest that strain BTP1 can elicit systemic phytoalexin accumulation in tomato as one defence mechanism. On another hand, we have shown that key enzymes of the lipoxygenase pathway are stimulated in plants treated with the bacteria as compared with control plants. Interestingly, this stimulation is observed only after pathogen challenge in agreement with the priming concept almost invariably associated with the ISR phenomenon. CONCLUSION: Through the demonstration of phytoalexin accumulation and LOX pathway stimulation in tomato, this work provides new insights into the diversity of defence mechanisms that are inducible by non-pathogenic bacteria in the context of ISR

Prospective functional classification of all possible missense variants in PPARG.

Clinical exome sequencing routinely identifies missense variants in disease-related genes, but functional characterization is rarely undertaken, leading to diagnostic uncertainty. For example, mutations in PPARG cause Mendelian lipodystrophy and increase risk of type 2 diabetes (T2D). Although approximately 1 in 500 people harbor missense variants in PPARG, most are of unknown consequence. To prospectively characterize PPARγ variants, we used highly parallel oligonucleotide synthesis to construct a library encoding all 9,595 possible single-amino acid substitutions. We developed a pooled functional assay in human macrophages, experimentally evaluated all protein variants, and used the experimental data to train a variant classifier by supervised machine learning. When applied to 55 new missense variants identified in population-based and clinical sequencing, the classifier annotated 6 variants as pathogenic; these were subsequently validated by single-variant assays. Saturation mutagenesis and prospective experimental characterization can support immediate diagnostic interpretation of newly discovered missense variants in disease-related genes.This work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (1K08DK102877-01, to A.R.M.; 1R01DK097768-01, to D.A.), NIH/Harvard Catalyst (1KL2TR001100-01, to A.R.M.), the Broad Institute (SPARC award, to A.R.M. and T.M.), and the Wellcome Trust (095564, to K.C.; 107064, to D.B.S.).This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.370

The Type 2 Diabetes Knowledge Portal: an Open access Genetic Resource Dedicated to Type 2 Diabetes and Related Traits

Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate the T2DKP\u27s comprehensiveness by comparing its datasets with those of other repositories. Second, we describe how researchers unfamiliar with human genetic data can begin using and correctly interpreting them via the T2DKP. Third, we describe how existing users can extend their current workflows to use the full suite of tools offered by the T2DKP. We finally discuss the lessons offered by the T2DKP toward the goal of democratizing access to complex disease genetic results

Breakfast (On the Edge of the Desert)

Music score to accompany book chapterNRFArt History, Visual Arts and Musicolog

‘Sounds of a cowhide drum’: challenges facing a new African musicology

This particular line of inquiry begins by invoking Agawu’s challenge (2004) to musicology, namely to take on the imaginative task of framing a new musical aesthetics grounded in African ways of being – what might be understood as a context-driven African musicology. After considering some salient aspects of drumming as a practice contributing to a sense of wellbeing and group identity, I examine three elements of musical categorisation (rhythm, syncopation and intonation) in the light of Bourdieu’s notion of the cultural field (1993), a useful theoretical concept for bringing to light the hidden structures of legitimation and authorisation that undergird discipline-specific discourses. In so doing, I consider the residual heritage of the aesthetic of disinterested contemplation which understands music as product rather than process, an approach nowadays widely perceived as highly problematic following the insights of the New Musicology. In conclusion, I propose some strategies for deconstructing the historical rhetoric of ‘othering’, through which African music was viewed by some as inferior to its counterpart in the West, and some further ways in which musicologists on this continent might begin to respond to Agawu’s rallying call

Marc Duby More Garde Than Avant Happen(dot)Stance

Art and Musi